Expression of cyclooxygenase-2, Bcl-2 and Ki-67 in pleomorphic adenoma with special reference to tumor proliferation and apoptosis

Aoki, Takayuki; Tsukinoki, Keiichi; Karakida, Kazunari; Ota, Yoshihide; Otsuru, Mitsunobu; Kaneko, Akihiro

doi:10.1016/j.oraloncology.2004.04.014

Cited by 42 publications

(34 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HGF expression might also par- ticipate in regulation of apoptosis of salivary gland tumors, since there was a correlation between expressions of c-Met and anti-apoptotic factor bcl-2. Moreover, cyclooxygenase (COX)-2 inhibits apoptosis which is mediated by bcl-2 expression in pleomorphic adenoma [3], and HGF is increased on the addition of rCox-2 in the HSG salivary gland carcinoma cell line (unpublished). These findings suggest that HGF may be the key molecule regulating progression in benign salivary gland tumors.…”

Section: Expression Of Hgf and C-met In Salivary Gland Tumorsmentioning

confidence: 99%

Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands

Tsukinoki

Yasuda

Miyoshi

et al. 2005

Acta Histochem. Cytochem

Self Cite

View full text Add to dashboard Cite

Section: Expression Of Hgf and C-met In Salivary Gland Tumorsmentioning

confidence: 99%

Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands

Tsukinoki

Yasuda

Miyoshi

et al. 2005

Acta Histochem. Cytochem

Self Cite

View full text Add to dashboard Cite

“…According to Yanez et al, bcl-2 plays an important role in the development of pleomorphic adenomas since all cases analyzed by the authors were positive forthis protein. Aoki et al (2004) also detected a high percentage of bcl-2-positive cases, with immunoreactivity being observed in 33 (94.3%) of 35 cases analyzed. The present findings are in contrast with these results since most cases were negative for bcl-2 protein, suggesting that this protein is not involved in the pathogenesis of pleomorphic adenoma.…”

Section: Discussionmentioning

confidence: 69%

Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas

Gordón-Núñez¹,

Godoy

Soares

et al. 2008

Int. J. Morphol.

View full text Add to dashboard Cite

GORDÓN-NÚÑEZ SUMMARY:The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas. Nineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies against p53, PCNA and bcl-2 proteins. It was observed weak labeling for p53 in 12 cases (63.1%) and for PCNA in 8 (42.1%). With respect to the bcl-2 labeling index, no expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably does not effectively participate in the pathogenesis of this tumor.

show abstract

“…Gordon-Nunez 25 found 37% and Al-Rawi 26 only 30% of their cases to be bcl-2 positive. However, Cruz-Perez 22 , Aoki 20 and Yanez…”

Section: Discussionmentioning

confidence: 99%

“…Generally, the failure of apoptotic control mechanisms, in which the B-cell lymphoma 2 (bcl-2) oncogene plays a very important role, is thought to prolong the cellular life span with the subsequnet occurrence of gene mutations resulting in the initiation and progression of tumours 18 . The expression of bcl-2 oncoprotein as a marker of apoptosis-free immortalized neoplastic stem cells was studied in both malignant and benign salivary tumours, suggesting the role of apoptosis inhibition in the oncogenesis of these neoplasms [19][20][21][22][23][24][25][26] . Debiec-Rychter detected immunohistochemical co-positivity of PLAG1 (pleomorphic adenoma gene 1) and bcl-2 gene in pleomorphic adenomas, suggesting their involvement in the initiation and recurrence of this tumour 24 .…”

Section: Introductionmentioning

confidence: 99%

Recurrent salivary pleomorphic adenoma shows increased immunohistologic expression of bcl-2 oncoprotein

Stárek¹,

Salzman²,

Kališ³

et al. 2015

BIOMED PAP

View full text Add to dashboard Cite

Background. Internal cell biology, including apoptotic regulation, is presumed to play a key role in the development of recurrent pleomorphic adenoma (PA). Aim. The aim of our study was to determine the relevance of B-cell lymphoma 2 (bcl-2) oncoprotein immunoexpression and distribution in primary PA, and its recurrence. Methods. Ten primary-non-recurrent, 14 primary-to-recur, and 28 recurrences of parotid PA patients aged 19-73 (mean 40.7±16.7) years were enrolled. The bcl-2 expression was compared between groups using a semi-quantitative histoscore, defined as the multiple of the percentage of cells by the intensity of immunostaining. Results. Widely varying bcl-2 immunoreaction was found in the epithelial areas of 91.7% of primary and 85.2% of recurrent PA. Similarly varying but much less, immunopositivity was found in the myxoid areas of 62.5% of primary and 71.4% of recurrent tumours. No obvious differences in the bcl-2 staining intensity or pattern of specific epithelial morphologic structures in either the primary-non-recurrent, primary-to-recur or recurrent tumours were found. In both the mesenchymal and epithelial areas of PA, the differences in bcl-2 immunohistoscore between the primary-nonrecurrent and primary-to-recur groups were not statistically significant (P=0.62, respectively 0.51). In the mesenchymal areas, the study revealed a significantly increased histoscore in recurrent tumours compared to their corresponding primaries (P=0.01). Increased bcl-2 expression in recurrent PA suggests an exaggerated aggressiveness of that tumor. Conclusion. The fact that a significant difference in the histoscore was found exclusively in the myxoid component seems to accord with the reported prevalence of the latter in recurrent and metastatic PA.

show abstract

Expression of cyclooxygenase-2, Bcl-2 and Ki-67 in pleomorphic adenoma with special reference to tumor proliferation and apoptosis

Cited by 42 publications

References 16 publications

Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands

Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands

Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas

Recurrent salivary pleomorphic adenoma shows increased immunohistologic expression of bcl-2 oncoprotein

Contact Info

Product

Resources

About