Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma

Cho, Young-Eun; Kim, Jee‐Youn; Kim, Youn-Wha; Park, Jaehoon; Lee, Sun

doi:10.1016/j.humpath.2008.12.007

Cited by 8 publications

(7 citation statements)

References 14 publications

(21 reference statements)

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“…FAM162A has further been shown to be HIF1alpha responsive and a mediator of the mitochondrial apoptotic pathway [ 47 ]. Its elevated expression has been observed in gastric and uterine carcinoma [ 48 , 49 , 50 ]. PLOD1 , the only commonly up-regulated gene in IDH1 mut and IDH1 wt GSCs under hypoxia, mediates crosslinking of collagen fibers and has shown to be regulated by HIF1alpha in breast cancer cells leading to increased invasion and metastasis [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma

Trong

Rösch

Mairbäurl

et al. 2018

IJMS

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Glioma growth is often accompanied by a hypoxic microenvironment favorable for the induction and maintenance of the glioma stem cell (GSC) phenotype. Due to the paucity of cell models of Isocitrate Dehydrogenase 1 mutant (IDH1mut) GSCs, biology under hypoxic conditions has not been sufficiently studied as compared to IDH1 wildtype (IDH1wt) GSCs. We therefore grew well-characterized IDH1mut (n = 4) and IDH1wt (n = 4) GSC lines under normoxic (20%) and hypoxic (1.5%) culture conditions and harvested mRNA after 72 h. Transcriptome analyses were performed and hypoxia regulated genes were further analyzed using the expression and clinical data of the lower grade glioma cohort of The Cancer Genome Atlas (LGG TCGA) in a confirmatory approach and to test for possible survival associations. Results show that global expression changes were more pronounced in IDH1wt than in IDH1mut GSCs. However, when focusing on known hypoxia-regulated gene sets, enrichment analyses showed a comparable regulation in both IDH1mut and IDH1wt GSCs. Of 272 significantly up-regulated genes under hypoxic conditions in IDH1mut GSCs a hypoxia-related survival score (HRS-score) of five genes (LYVE1, FAM162A, WNT6, OTP, PLOD1) was identified by the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm which was able to predict survival independent of age, 1p19q co-deletion status and WHO grade (II vs. III) in the LGG TCGA cohort and in the Rembrandt dataset. Altogether, we were able to identify and validate a novel hypoxia-related survival score in IDH1mut GSCs consisting of five hypoxia-regulated genes which was significantly associated with patient survival independent of known prognostic confounders.

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Section: Discussionmentioning

confidence: 99%

Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma

Trong

Rösch

Mairbäurl

et al. 2018

IJMS

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“…Cho et al [25] studied the cell kinetics In stage I and stage II patients, a higher geminin labeling index (LI; >25%) did not correlate with poorer survival (A and B; P < 0.54 and P < 0.73, respectively). The cumulative survival of the 55 patients in stage I-IV with a high geminin LI (>25%) was signifi cantly poorer than that of the 73 patients in stage I-IV with a low LI (≤25%) (P < 0.04; D).…”

Section: Discussionmentioning

confidence: 99%

Geminin, Ki67, and minichromosome maintenance 2 in gastric hyperplastic polyps, adenomas, and intestinal-type carcinomas: pathobiological significance

et al. 2010

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“…Compared with the WHO classification and Lauren classification, Roukos reported that, in general, well and moderately differentiated cancers according to the WHO classification correspond to the intestinal type of Lauren, whereas poorly or undifferentiated and signet ring cell carcinomas correspond to the diffuse type [10]. Different types of Lauren gastric carcinoma have different biological behaviours [11-13]. For the intestinal type, the macroscopic margins correspond approximately to the microscopic extent of the tumour.…”

Section: Introductionmentioning

confidence: 99%

Double contrast-enhanced ultrasonography evaluation of preoperative Lauren classification of advanced gastric carcinoma

Huang¹,

Li²,

Aronow³

et al. 2011

aoms

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IntroductionThe clinical value of double contrast-enhanced ultrasonography (DCUS) in determining the Lauren classification of advanced gastric carcinoma needed investigation.Material and methodsFifty-eight patients with gastric cancer proved by endoscopic biopsy underwent preoperative DCUS examination in which an oral contrast agent was combined with an intravenous agent, and the findings were compared with the postoperative pathological findings using haematoxylin-eosin and Alcian Blue-Periodic Acid Schiff (AB-PAS) staining.ResultsOf 58 patients, 34 (59%) were the intestinal type and 24 (41%) the diffuse type on pathological examination of resected specimens. Among intestinal type patients, 30 (88%) showed homogeneous vascular enhancement and 4 (12%) heterogeneous enhancement with the “sandwich” pattern in 2 patients (50%) and “barrier” pattern in 2 patients (50%). In the diffuse type, 22 of 24 patients (92%) enhanced heterogeneously, with stippled and peripheral enhancement in 9 (41%), the “sandwich” pattern in 8 (36%) and “barrier” pattern in 5 (23%). Two of 24 patients (8%) with the diffuse type enhanced homogeneously. The proportion of heterogeneous enhancement was significantly different between the 2 subtypes of tumour (p = 0.0001). The sensitivity and specificity of heterogeneous enhancement in diagnosing the diffuse type of advanced gastric cancer were 92% and 88%, respectively. Youden’s index was 0.8.ConclusionsDouble contrast-enhanced ultrasonography is a new and useful method to determine Lauren classification in patients with gastric carcinoma.

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Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma

Cited by 8 publications

References 14 publications

Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma

Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma

Geminin, Ki67, and minichromosome maintenance 2 in gastric hyperplastic polyps, adenomas, and intestinal-type carcinomas: pathobiological significance

Double contrast-enhanced ultrasonography evaluation of preoperative Lauren classification of advanced gastric carcinoma

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