Double contrast-enhanced ultrasonography evaluation of preoperative Lauren classification of advanced gastric carcinoma

Huang, Pintong; Li, Shiyan; Aronow, Wilbert S.; Wang, Zongmin; Nair, Chandra K.; Xue, Ning; Shen, Xuedong; Chen, Chengchun; Cosgrove, David

doi:10.5114/aoms.2011.22080

Cited by 23 publications

(19 citation statements)

References 35 publications

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“…The sensitivity and specificity of heterogeneous enhancement of CEUS in diagnosing undifferentiated gastric cancer were 78.84% and 72.59% respectively. Our previous study also implied that the heterogeneous pattern was more common in diffuse than in intestinal cancers using the Lauren classification [45].…”

Section: Discussionmentioning

confidence: 87%

Enhancement Patterns of Gastric Carcinoma on Contrast-Enhanced Ultrasonography: Relationship with Clinicopathological Features

Wei

Huang

et al. 2013

PLoS ONE

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The aim of this study was to assess the relationship between the enhancement patterns and clinicopathological features of gastric cancer using intravenous contrast-enhanced ultrasonography (CEUS). In this Ethics Committee-approved prospective study, five hundred fifty two patients with gastric cancer who gave informed consent were examined preoperatively with CEUS. The enhancement pattern of each tumor was analyzed visually. Gross and histopathological findings on the postoperative specimens were compared with the preoperative CEUS findings. The most common CEUS pattern in differentiated gastric cancer was homogeneous enhancement, whereas heterogeneous enhancement was the most common pattern in undifferentiated gastric cancer. The proportion of heterogeneous enhancement was significantly different between the two histological subtypes (Chi- square = 146.735, P<0.001). The sensitivity and specificity of early heterogeneous enhancement on CEUS in diagnosing undifferentiated gastric cancer were 78.84% and 72.59% respectively. Gastric cancers with heterogeneous enhancement were more often Borrmann III and IV macroscopic types than those with homogeneous enhancement (66.56% vs. 30.80%, P<0.001), more commonly T3 and T4 depth of invasion than those with homogeneous enhancement (71.52% vs. 59.60%, P<0.05), more often showed lymphatic invasion than those with homogeneous enhancement (84.44% vs. 76.40%, P<0.05), and were less likely to receive curative gastrectomy than those with homogeneous enhancement (74.83% vs. 86.40%, P<0.005). The intra- and inter-observer reproducibility were both almost perfect for assessing enhancement patterns, with Kappa values of 0.916 (P<0.001) for intra-observer and 0.842 (P<0.001) for inter-observer reproducibility. CEUS provided detailed information about tumor vascularity and contrast enhancement patterns in gastric cancer. CEUS is promising as a new and useful method to predict the histological type of gastric cancer.

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Section: Discussionmentioning

confidence: 87%

Enhancement Patterns of Gastric Carcinoma on Contrast-Enhanced Ultrasonography: Relationship with Clinicopathological Features

Wei

Huang

et al. 2013

PLoS ONE

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“…Given the complication of the history of chronic gastritis, abdominal ultrasound was ordered and found that there was nonuniform thickening of the gastric antrum wall. DCEUS has been widely used for diagnosis of gastric cancer in China [4]. It can be used in the preoperative staging of gastric cancer and has been widely applied in clinics.…”

Section: Discussionmentioning

confidence: 99%

Primary gastric cancer presenting with a metastatic embolus in the common carotid artery: a case report

Zhang

Shentu

et al. 2012

World J Surg Onc

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Although about 30% of gastric cancers have distant metastasis at the time of initial diagnosis, metastatic tumor embolus in the main blood vessels is not common, especially in the main artery. The report presents, for the first time, an extremely rare clinical case of a metastatic embolus in the common carotid artery (CCA) from primary gastric cancer. Metastatic embolus from the primary tumor should be considered when patients present with gastric cancer accompanied by intravascular emboli. The patient should be actively examined further so as to allow early detection and treatment.

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“…This seems to be another strategy that might improve bowel wall diagnostic imaging over that of gray-scale US. 33,[44][45][46][47] However, at present, gastroscopy, CT, and endoscopic US remain the gold standard in tumor characterization and staging.…”

Section: Possible Indications For Eceusmentioning

confidence: 99%

Endocavitary contrast‐enhanced ultrasound: A technique whose time has come?

Müller

Blank

Leitlein

et al. 2014

J of Clinical Ultrasound

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Endocavitary use of contrast agents in sonography (US) is a relatively new method in diagnostic imaging, competing against gray-scale US, fluoroscopy, and endoscopy. This article describes established indications, demonstrates the techniques of evolving applications, and discusses their potential benefits. These benefits include the ability to obtain precise information about the placement of drains and the extent of fluid collections, and to accurately identify the location and features of strictures in various organs, and those of complications of fluid collections or abscesses, without resorting to ionizing radiation.

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Double contrast-enhanced ultrasonography evaluation of preoperative Lauren classification of advanced gastric carcinoma

Cited by 23 publications

References 35 publications

Enhancement Patterns of Gastric Carcinoma on Contrast-Enhanced Ultrasonography: Relationship with Clinicopathological Features

Enhancement Patterns of Gastric Carcinoma on Contrast-Enhanced Ultrasonography: Relationship with Clinicopathological Features

Primary gastric cancer presenting with a metastatic embolus in the common carotid artery: a case report

Endocavitary contrast‐enhanced ultrasound: A technique whose time has come?

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