Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

Karia, Bruno Takao Real; Zamuner, Fernando T.; Carlin, Viviane; Oliveira, Cleyton Zanardo de; Carvalho, André Lopes; Vettore, André Luiz

doi:10.2174/1566524018666180322162145

Cited by 10 publications

(8 citation statements)

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“…15,21,22 Importantly, previous studies showed that MAGE-A11, a key oncoprotein correlation with poor prognosis and survival in cancer, plays crucial role in the development of HNSCC. 23,24 Hartmann et al shows that MAGE-A11 expression contributes to cisplatin resistance in head and neck cancer. 25 We hypothesized that MAGE-A11 expression may be a predictor of malignant transformation in HNSCC.…”

Section: Discussionmentioning

confidence: 99%

<p>MAGE-A11 Expression Predicts Patient Prognosis in Head and Neck Squamous Cell Carcinoma</p>

Jia

Zhang

et al. 2020

CMAR

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Background: Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer worldwide. Growing evidence showed that Melanoma-associated antigen-A11 (MAGE-A11) was abnormally expressed in various malignancies, but MAGE-A11 expression and its biological roles in HNSCC had not been reported in detail. The aim of the study was to investigate the association between MAGE-A11 signatures and clinicopathological features of HNSCC patients and uncover its potential mechanisms in HNSCC patients. Methods: In the present study, we analyzed the expression of MAGE-A11 gene and evaluated the impact of MAGE-A11 genes expression on clinical outcome from the Cancer Genome Atlas (TCGA) database. MAGE-A11 expression was assessed in a wellcharacterized series of HNSCC (N = 75) with long-term follow-up and 10 cases of adjacent non-cancerous tissues, which were diagnosed between 2013 and 2014, by using immunohistochemistry. The correlation between MAGE-A11 expression and clinicopathological factors was analyzed. Kaplan-Meier and Cox regression analyses were used to assess the prognostic significance of MAGE-A11 expression among HNSCC patients. Results: The results showed that MAGE-A11 mRNA expression was increased in HNSCC tissues compared to "normal" tissues (P < 10 −12). MAGE-A11 protein expression was not correlated with lymph node status, relapse, age, gender, histological grade, differentiation, clinical stage, tumor size, radiotherapy or chemotherapy. The patients with high MAGE-A11 expression had lower 5-year overall survival (OS) rates than those with low MAGE-A11 expression as determined using the Kaplan-Meier method. The univariate and multivariate analyses confirmed that elevated MAGE-A11 was an independent prognostic factor for the OS of HNSCC patients. Conclusion: These findings indicate that MAGE-A11 may be a valuable diagnostic or prognostic marker as well as a potential molecular therapy target for HNSCC patients.

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Section: Discussionmentioning

confidence: 99%

<p>MAGE-A11 Expression Predicts Patient Prognosis in Head and Neck Squamous Cell Carcinoma</p>

Jia

Zhang

et al. 2020

CMAR

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“…Substantial evidence exists for the expression of CTAs in HNSCCs. MAGE family members are often detected [ 126 , 127 , 128 , 129 , 130 , 131 ]. In HPV neg HNSCC, the expression of MAGEA1 and MAGEA4 was associated with shorter OS [ 132 , 133 ].…”

Section: Tumour-associated Antigens (Taas)mentioning

confidence: 99%

“…New York esophageal squamous cell carcinoma 1 antigen (NY-ESO-1) is expressed in numerous cancer types, including HNSCC [ 126 , 127 , 128 , 129 , 130 , 131 ]. Increased expression of NY-ESO-1 is associated with a higher risk of recurrence, poor response to treatment and shorter survival in HNSCCs [ 102 , 133 ].…”

Section: Tumour-associated Antigens (Taas)mentioning

confidence: 99%

“…SSX2-specific antibody responses can found in HNSCC patients’ serum [ 130 ], confirming immunogenicity. Other CTA families such as B melanoma antigen (BAGE), G antigen (GAGE), renal tumour antigen (RAGE), sarcoma antigen (SAGE) and X antigen family (XAGE) members are also variably expressed [ 130 , 131 , 142 ]. No study has yet reported the association of their expression level and clinical outcomes.…”

Section: Tumour-associated Antigens (Taas)mentioning

confidence: 99%

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HNSCC: Tumour Antigens and Their Targeting by Immunotherapy

Witzleben

Wang

Laban

et al. 2020

Cells

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Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of malignant tumours typically caused by alcohol and tobacco consumption, although an increasing number of HNSCC arise due to persistent infection with high-risk human papilloma virus (HPV). The treatment of HNSCC remains challenging, and the first-line setting is focused on surgery and chemoradiotherapy. A substantial proportion of HNSCC patients die from their disease, especially those with recurrent and metastatic disease. Among factors linked with good outcome, immune cell infiltration appears to have a major role. HPV-driven HNSCC are often T-cell rich, reflecting the presence of HPV antigens that are immunogenic. Tumour-associated antigens that are shared between patients or that are unique to an individual person may also induce varying degrees of immune response; studying these is important for the understanding of the interaction between the host immune system and the cancer. The resulting knowledge is critical for the design of better immunotherapies. Key questions are: Which antigens lead to an adaptive immune response in the tumour? Which of these are exploitable for immunotherapy? Here, we review the current thinking regarding tumour antigens in HNSCC and what has been learned from early phase clinical trials.

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“…Studies on the sponging properties of circ_0016760 indicate that it has valid ceRNA properties in modulating the mir-1287/GAGE1 signaling axis in lung cancer. GAGE1 is a proposed indicator of cancer progression, as studies correlated its overexpression lymph node metastasis and advanced clinical staging (Karia et al, 2017). The 3 0 -UTR of GAGE1 mRNA can be targeted by mir-1287, thus inhibiting its transition and therefore inducing downregulation.…”

Section: Circrnas As Cernas With Examples In Lung Cancermentioning

confidence: 99%

Critical function of circular RNAs in lung cancer

et al. 2020

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Lung cancer is one of the main causes of cancer-related death in the world, especially due to its frequency and ineffective therapeutically approaches in the late stages of the disease. Despite the recent advent of promising new targeted therapies, lung cancer diagnostic strategies still have difficulty in identifying the disease at an early stage. Therefore, the characterizations of more sensible and specific cancer biomarkers have become an important goal for clinicians. Circular RNAs (circRNAs), a type of RNA with covalently closed continuous loop structures that display high structural resistance and tissue specificity pointed toward a potential biomarker role. Current investigations have identified that circRNAs have a prominent function in the regulation of oncogenic pathways, by regulating gene expression both at transcriptional and post-transcriptional level. The aim of this review is to provide novel information regarding the implications of circRNAs in lung cancer, with an emphasis on the role in disease development and progression. Initially, we explored the potential utility of circRNAs as biomarkers, focusing on function, mechanisms, and correlation with disease progression in lung cancer. Further, we will describe the interaction between circRNAs and other non-coding species of RNA (particularly microRNA) and their biological significance in lung cancer.Rares Drula and Cornelia Braicu are co-first authors contributed equally to this study.

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Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

Abstract: These findings suggest GAGE1 and XAGE1 expressions to be useful as prognostic markers for HNSCC.

Cited by 10 publications

References 0 publications

<p>MAGE-A11 Expression Predicts Patient Prognosis in Head and Neck Squamous Cell Carcinoma</p>

<p>MAGE-A11 Expression Predicts Patient Prognosis in Head and Neck Squamous Cell Carcinoma</p>

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy

Critical function of circular RNAs in lung cancer

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