<p>MAGE-A11 Expression Predicts Patient Prognosis in Head and Neck Squamous Cell Carcinoma</p>

Abstract

Background: Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer worldwide. Growing evidence showed that Melanoma-associated antigen-A11 (MAGE-A11) was abnormally expressed in various malignancies, but MAGE-A11 expression and its biological roles in HNSCC had not been reported in detail. The aim of the study was to investigate the association between MAGE-A11 signatures and clinicopathological features of HNSCC patients and uncover its potential mechanisms in HNSCC patients. Methods: In the present study, we analyzed the expression of MAGE-A11 gene and evaluated the impact of MAGE-A11 genes expression on clinical outcome from the Cancer Genome Atlas (TCGA) database. MAGE-A11 expression was assessed in a wellcharacterized series of HNSCC (N = 75) with long-term follow-up and 10 cases of adjacent non-cancerous tissues, which were diagnosed between 2013 and 2014, by using immunohistochemistry. The correlation between MAGE-A11 expression and clinicopathological factors was analyzed. Kaplan-Meier and Cox regression analyses were used to assess the prognostic significance of MAGE-A11 expression among HNSCC patients. Results: The results showed that MAGE-A11 mRNA expression was increased in HNSCC tissues compared to "normal" tissues (P < 10 −12). MAGE-A11 protein expression was not correlated with lymph node status, relapse, age, gender, histological grade, differentiation, clinical stage, tumor size, radiotherapy or chemotherapy. The patients with high MAGE-A11 expression had lower 5-year overall survival (OS) rates than those with low MAGE-A11 expression as determined using the Kaplan-Meier method. The univariate and multivariate analyses confirmed that elevated MAGE-A11 was an independent prognostic factor for the OS of HNSCC patients. Conclusion: These findings indicate that MAGE-A11 may be a valuable diagnostic or prognostic marker as well as a potential molecular therapy target for HNSCC patients.

Haplotype-resolved inversion landscape reveals hotspots of mutational recurrence associated with genomic disorders

“…4D, Supplementary Notes). This locus, which contains the gene MAGEA11 implicated in cancer progression (James et al 2013;Su et al 2019;Jia et al 2020), was confidently identified as toggling using our tiSNP-and haplotype-based approaches (Table 1) and, additionally, was subject to inversion during primate genome evolution (Fig. S32).…”

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy

“…MAGEB6 presented significant association with poor disease outcome, whilst conversely, MAGEA3 and MAGEA6 were reported as a biomarker for longer disease-free survival (DFS) [ 129 ]. MAGEA11 mRNA expression was significantly associated with advanced clinical stage and metastasis in lymph nodes [ 134 ]. IgG antibody responses against MAGE antigens can be detected in HNSCC patients’ serum [ 130 ].…”

Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma

“…Head and neck squamous cell carcinoma (HNSCC) has been introduced as the sixth most common malignancy globally. HNSCC originates from various subsites of the upper aerodigestive tract, such as the oral cavity, larynx, pharynx, paranasal sinuses and nasal cavity [1][2][3][4]. Despite current efforts for the risk stratification and treatment of patients with HNSCC, the overall survival (OS) rate of these patients is unsatisfactory and has not significantly improved over the past decade, which may be because of late-stage diagnosis.…”