Exposure to methylene chloride. Content in subcutaneous adipose tissue.

Engström, Jörgen; Bjurström, Rasmus

doi:10.5271/sjweh.2771

Cited by 20 publications

(11 citation statements)

References 9 publications

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“…Although skin absorption is recognized as a possible major route of entry for some solvents, it has been studied for only a few. Engstrom and Bjurstrom [1977] found that brief (10-15 minute) immersion of a subject's hands in xylene produced blood concentrations of xylene comparable to those following an 8-hour inhalation exposure at 100 ppm (the threshold limit value [TLV]). The rate of solvent uptake through the skin varies substantially among workers owing to variations in skin thickness, skin perfusion, and the presence of cuts or abrasions of the skin Bird, 19811.…”

Section: Uptakementioning

confidence: 99%

The neurotoxicity of industrial solvents: A review of the literature

Baker

Smith

Landrigan

1985

American J Industrial Med

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Organic solvents, particularly stryrene, are used widely in boatbuilding. They may be absorbed by workers either through the respiratory tract or the skin. Uptake is influenced by level and duration of exposure, work load, and specific physiochemical features of each solvent, as well as by work practices and use of protective equipment. Kinetics of metabolism and excretion kinetics are highly variable among compounds. Metabolites can be measured in blood, urine, or exhaled breath and may serve as indirect indices of absorption. Acute high-dose exposure to organic solvents can produce a transient narcotic effect on the central nervous system. This effect occurs in proportion to brain dose, which in turn is determined by intensity and duration of exposure. Additionally, chronic exposures to organic solvents have been reported to produce an increased frequency of neurologic signs and symptoms. These findings include peripheral neuropathies and toxic encephalopathies. The latter are characterized by alterations in affect, memory loss, and impaired cognition. Concern exists that prolonged excessive exposure to organic solvents may lead to premature and persistent dementia in certain workers.

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Section: Uptakementioning

confidence: 99%

The neurotoxicity of industrial solvents: A review of the literature

Baker

Smith

Landrigan

1985

American J Industrial Med

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“…The elimination of these solvents from adipose tissue in man is relatively slow (1,8,9,10,11,12), a phenomenon indicating a potential risk of prolonged exposure to such lipophilic solvents. In the present study mice were exposed to acetone, as it is of interest to compare the distribution and elimination pattern of the highly water-soluble acetone (19) with those of the earlier studied lipophilic organic solvents.…”

Section: Reprint Requests To: Ms E Wigaeus Researchmentioning

confidence: 99%

Distribution and elimination of 2-[14C]-acetone in mice after inhalation exposure.

Wigaeus¹,

Löf²,

Nordqvist³

1982

Scand J Work Environ Health

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“…The concentrations of methylene chloride in subcutaneous adipose tissue after experimental exposure were determined in a previous study from this laboraitory (8,9). Methylene chloride is a vola-tile solvent with a relMi~e'ly :poor affinity for adipose tissue.…”

mentioning

confidence: 99%