Distribution and elimination of 2-[14C]-acetone in mice after inhalation exposure.

Wigaeus, Ewa; Löf, Agneta; Nordqvist, Marianne

doi:10.5271/sjweh.2486

Cited by 11 publications

(4 citation statements)

References 15 publications

(27 reference statements)

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“…This result is in agreement with a prior study showing seizure protection lasting up to 4 to 5 h in the AY‐9944 model (Likhodii et al, 2003). The prolonged duration is consistent with acetone's metabolic half‐life, which is in the range of 2–5 h in mice (Wigaeus et al, 1982). The effective doses of acetone in the present study are similar to those reported previously to protect against seizures in mice (Rho et al, 2002) and rats (Likhodii et al, 2003).…”

Section: Discussionsupporting

confidence: 74%

The Anticonvulsant Activity of Acetone, the Major Ketone Body in the Ketogenic Diet, Is Not Dependent on Its Metabolites Acetol, 1,2‐Propanediol, Methylglyoxal, or Pyruvic Acid

et al. 2007

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Summary:Background: Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet, exhibits anticonvulsant properties that may contribute to the seizure protection conferred by the diet. The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role.Methods: Acetone and its major metabolites-acetol, 1,2-propanediol, methylglyoxal, and pyruvic acid-were assessed for anticonvulsant activity in two mouse seizure models. Various doses of the substances administered intraperitoneally were characterized for their ability to elevate the threshold for clonic seizures induced by intravenous infusion of pentylenetetrazol (PTZ) and for protection against tonic seizures induced by subcutaneous bolus administration of 4-aminopyridine (4-AP). The inverted-screen test was used to assess acute neurological toxicity.Results: Acetone (1-32 mmol/kg, i.p.), in a dose-dependent fashion, elevated the PTZ threshold and conferred protection against 4-AP seizures (ED 50 , 26.3 mmol/kg). Effective doses of acetone (10-32 mmol/kg) did not cause motor impairment in the inverted-screen test (TD 50 , 45.7 mmol/kg). In doses 10-fold greater than the minimally effective dose of acetone (3.2 mmol/kg), the metabolites acetol, 1,2-propanediol, and pyruvic acid were inactive in the PTZ model. At higher doses that produced motor impairment, acetol and 1,2-propanediol (but not pyruvic acid) did elevate the PTZ threshold. Methylglyoxal had both proconvulsant and anticonvulsant actions, and had substantial toxicity, producing respiratory distress, motor impairment, and death. None of the acetone metabolites protected against 4-AP seizures.Conclusions: This study confirms the broad-spectrum anticonvulsant properties of acetone and indicates that the seizure protection conferred is unlikely to result from its major metabolic products.

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Section: Discussionsupporting

confidence: 74%

The Anticonvulsant Activity of Acetone, the Major Ketone Body in the Ketogenic Diet, Is Not Dependent on Its Metabolites Acetol, 1,2‐Propanediol, Methylglyoxal, or Pyruvic Acid

et al. 2007

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“…Studies in rodents have shown that 2-propanone is rapidly absorbed by the inhalation route, with peak blood levels occurring quickly after the onset of exposure. The equilibrium state is reached 2 h, 6 h and 3-4 d after exposure to 150 ppm, 500 ppm, and 2210 ppm 2-propanone, respectively (Geller et al, 1979;Wigaeus et al, 1982). The time needed to reach equilibrium state increased with the concentration, which suggests concentration-dependent kinetics.…”

Section: Discussionmentioning

confidence: 95%

“…Absorption through the skin occurs rapidly in humans. Studies in animals indicate that 2-propanone can be found in the blood, lungs, kidneys, liver, brain, pancreas, spleen, thymus, heart, testes, vas deferens, muscles and subcutaneous and intraperitoneal white adipose tissue (Wigaeus et al, 1982). After 24-h exposure to 14 C-labelled 2-propanone at 500 ppm (1200 mg/m 3 ), a low level of accumulation was observed in the tissues, with the exception of brown adipose tissue and the liver.…”

Section: Discussionmentioning

confidence: 99%

Technical note: Residues of gaseous air pollutants in rabbit (Oryctolagus cuniculus) tissues

et al. 2020

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The modern consumer is concerned not only for meat quality, but also about animal welfare and the environment. Studies were conducted to determine the concentration of gaseous residues in the tissues of rabbits. For this purpose, gaseous air pollutants were measured at the height of rabbit cages. Immediately after slaughter, samples were taken for analysis to determine the level of residual pollutants in the tissues (blood, perirenal fat and lung). Headspace gas chromatography was performed on the tissue samples to test for volatile toxic substances. Gas residues of 11 compounds were determined in the samples of blood, perirenal fat and lungs. The same chemicals were present in the air of the farm and the animal tissues, which may indicate their capacity for bioaccumulation. We recommend that the results should be used to develop guidelines regarding the welfare of meat rabbits and requirements for laboratory rabbits.

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“…Eine dermale Aufnahme wurde ebenfalls nachgewiesen, erfolgt jedoch nur langsam und ist in der Praxis ohne Bedeutung [16]. Bedingt durch die hohe Wasserlöslichkeit und nur mäßige Fettlöslichkeit verteilt sich Aceton im Körper rasch und weitgehend vollständig in alle Organe [17]. Eine Akkumulation von 14 C-Kohlenstoff in braunem Fettgewebe und in der Leber wird darauf zurückgeführt, dass Aceton in diesen Geweben in starkem Maße metabolisiert und die Metaboliten im Intermediärstoffwechsel verwertet werden, wodurch es zu einer 14 C-Markierung zahlreicher normaler zellulärer Stoffwechselprodukte wie etwa Glucose, Acetyl-CoA und Makromolekülen kommt.…”

Section: Mitteilung Des Ausschusses Für Innenraumrichtwerte ( Air)unclassified

Richtwerte für Aceton in der Innenraumluft

2021

Bundesgesundheitsbl

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Distribution and elimination of 2-[14C]-acetone in mice after inhalation exposure.

Cited by 11 publications

References 15 publications

The Anticonvulsant Activity of Acetone, the Major Ketone Body in the Ketogenic Diet, Is Not Dependent on Its Metabolites Acetol, 1,2‐Propanediol, Methylglyoxal, or Pyruvic Acid

The Anticonvulsant Activity of Acetone, the Major Ketone Body in the Ketogenic Diet, Is Not Dependent on Its Metabolites Acetol, 1,2‐Propanediol, Methylglyoxal, or Pyruvic Acid

Technical note: Residues of gaseous air pollutants in rabbit (Oryctolagus cuniculus) tissues

Richtwerte für Aceton in der Innenraumluft

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