Exposure to Cadmium, Lead, and Tobacco Smoke and the 10-Year Cumulative Incidence of Olfactory Impairment

Schubert, Carla R.; Pinto, Alex; Paulsen, Adam; Cruickshanks, Karen J.

doi:10.1001/jamaoto.2021.0079

Cited by 9 publications

(7 citation statements)

References 56 publications

(190 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Beaver Dam Offspring Study (BOSS; 2005 to 2021) is a longitudinal cohort study of sensory and cognitive aging in adults. The baseline (2005 to 2008; N = 3298; aged 21 to 84 y) and follow-up examinations at 5 (2010 to 2013; N = 2873) and 10 years (2015 to 2017; N = 2466) included a blood draw, measurement of height and weight, and demographic and behavioral and medical health history questionnaires 8 . Approval for this research was obtained from the Health Sciences Institutional Review Board at the University of Wisconsin.…”

Section: Methodsmentioning

confidence: 99%

“…The limit of detection (LOD) for cadmium was 0.21 µg/L and the limit of quantification (LOQ) for lead was 0.30 µg/dL. Values below the LOD/LOQ were set to halfway between zero and the LOD/LOQ (cadmium: 0.10 µg/L; lead: 0.15 µg/dL) 8 …”

Section: Methodsmentioning

confidence: 99%

“…Cadmium and lead exposure have been associated with sensory impairments, decreased cognitive function, neurological symptoms and neurodegenerative diseases, and AD-specific mortality 8,9 . Despite the evidence that exposure to cadmium and lead can have adverse effects on the brain, there are few longitudinal studies of cadmium and lead and the development of dementia.…”

mentioning

confidence: 99%

“…Cadmium and lead exposure have been associated with sensory impairments, decreased cognitive function, neurological symptoms and neurodegenerative diseases, and ADspecific mortality. 8,9 Despite the evidence that exposure to cadmium and lead can have adverse effects on the brain, there are few longitudinal studies of cadmium and lead and the development of dementia. The potentially long intervening time between exposures to these environmental contaminants and the onset of clinical disease has presented challenges for studying these heavy metals as risk factors for neurodegeneration and dementia.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease

Schubert,

Paulsen,

Pinto

et al. 2023

Alzheimer Disease &Amp; Associated Disorders

Self Cite

View full text Add to dashboard Cite

Aim: To determine whether exposure to neurotoxins in midlife is associated with changes in blood-based biomarkers of neurodegeneration and Alzheimer disease pathology. Methods: Blood cadmium, lead, neurofilament light (NfL) chain, total tau (TTau), and amyloid beta (Aβ) 40 and Aβ42 concentrations were measured in 1516 participants in the Beaver Dam Offspring Study. Linear mixed-effect models were used to determine associations between baseline cadmium and lead levels and baseline NfL, TTau, and Aβ42/Aβ40, and 10-year change in concentrations using repeated measures of these biomarkers as the outcome. Results: In women, higher cadmium and lead levels were associated with higher baseline TTau concentrations. A higher baseline cadmium level was associated with lower baseline Aβ42/Aβ40 in both men and women. In age-sex-adjusted models, a doubling in baseline cadmium level was associated with a 0.2% (95% CI: 0.0, 0.3) higher increase per year in NfL concentrations. In men, a doubling of baseline lead level was associated with a 0.9% (95% CI: 0.1, 1.7) higher increase per year in TTau concentration. Conclusions: Participants with relatively higher levels of cadmium and lead had blood biomarker concentrations consistent with more neuronal damage and Alzheimer disease pathology. Environmental exposure to neurotoxins may contribute to neurodegeneration.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of Neurotoxin Exposure on Blood Biomarkers of Neurodegeneration and Alzheimer Disease

Schubert,

Paulsen,

Pinto

et al. 2023

Alzheimer Disease &Amp; Associated Disorders

Self Cite

View full text Add to dashboard Cite

show abstract

“…Peggioramento delle funzioni cognitive e difficoltà di apprendimento sono state correlate a un incremento dell'attività acetilcolinesterasica e un decremento dell'attività della sodio-potassio ATPasi provocate dal cadmio [20]. Infine, il cadmio appare il mediatore del fumo di tabacco, attraverso i meccanismi sopra descritti, nell'insorgenza del k rene [21], dell'osteoporosi [22], delle cardiovasculopatie [23], di peggioramento dell'olfatto [24] e delle arteriopatie periferiche [9].…”

Section: Altre Problematiche Cadmio-correlateunclassified

Ruolo del cadmio nelle patologie correlate all’uso di tabacco

PISTONE¹,

Zagà

CAMMARATA³

2021

Tabaccologia

View full text Add to dashboard Cite

Il fumo di tabacco esercita la propria azione nociva sull'organismo attraverso migliaia di sostanze ed elementi. Tra essi, i metalli sono significativamente presenti e per alcuni gli effetti proinfiammatorio e cancerogeno, diretto e indiretto, sono ben noti. Il cadmio è un fondamentale agente tossico presente nel tabacco che, a causa dell'alterazione della clearance muco-ciliare tipica del fumatore cronico, nonché della sua lunga emivita, può esercitare per molto tempo la sua azione, giocando un ruolo importante nella patogenesi di molte patologie fumo-correlate. L'identificazione di questo agente dovrebbe indurre l'industria dei prodotti del tabacco a investire seriamente per l'applicazione di strategie di de-cadmiazione che possano ridurne (o azzerarne) la presenza nella pianta di tabacco, o durante la lavorazione della foglia. D'altro canto è stato dimostrato che nei fumatori cronici, un adeguato apporto di zinco e/o l'utilizzo di farmaci che riattivano la clearance mucociliare possono ridurre l'incidenza e/o la gravità di diverse patologie fumo-correlate anche perché contrastano la presenza e l'attività del cadmio nell'organismo.

show abstract