Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

“…Kubo et al (2001), supported by the Japanese Ministry of Education, Science, and Culture, examined the effect of prenatal bisphenol A exposure on sexually dimorphic behavior and brain development in rats.…”

Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism

“…In vivo studies examining the effects of low dose BPA on TH signaling have suggested that perinatally exposed rats have elevated T4 levels on postnatal day (PND) 15 and up-regulation of a TH responsive gene in the brain (Zoeller et al, 2005). Furthermore, perinatal exposure to low dose BPA in rats has been implicated in the abnormal brain development, characterized by hyperactivity and impaired cognition (Carr et al, 2003;Kubo et al, 2001). It was also observed in medaka fish that the acceleration in embryonic development Toxicology and Applied Pharmacology 259 (2012) [133][134][135][136][137][138][139][140][141][142] and time to hatch induced by BPA are blocked by a TR antagonist, suggesting that BPA is acting through a TH pathway (Ramakrishnan and Wayne, 2008).…”

Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System

“…It has been reported that administration of BPA to pregnant mice at a dose that is within the range of the environmental levels that humans are typically exposed to causes remarkable changes in the postnatal growth rate and leads to early onset of puberty in these mice (Howdeshell et al, 1999). Recently, it has been reported that prenatal exposure to BPA disrupts the brain sexual differentiation and sociosexual behaviors in rats (Kubo et al, 2001;Farabollini et al, 2002). In this review article, we summarize the effects of prenatal exposure to BPA on the central nervous system (CNS).…”