Exposure to alcohol and tobacco smoke causes oxidative stress in rats

Ignatowicz, Ewa; Woźniak, Anna; Kulza, Maksymilian; Seńczuk-Przybyłowska, Monika; Cimino, Francesco; Piekoszewski, Wojciech; Chuchracki, Marek; Florek, Ewa

doi:10.1016/s1734-1140(13)71072-7

Cited by 35 publications

(23 citation statements)

References 42 publications

(38 reference statements)

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“…In addition, it was reported that CAT activity decreased upon chronic ethanol consumption in a study [20]. However, another study showed that CAT activity was increased in rat liver [18]. In our study, the alcohol treatment significantly increased the activity of SOD and slightly decreased the activity of CAT, while treatment with lemon juice decreased the activities of SOD and CAT.…”

Section: Discussioncontrasting

confidence: 40%

Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice

Zhou

Zhang

et al. 2017

BioMed Research International

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Chronic excessive alcohol consumption (more than 40–80 g/day for males and more than 20–40 g/day for females) could induce serious liver injury. In this study, effects of lemon juice on chronic alcohol-induced liver injury in mice were evaluated. The serum biochemical profiles and hepatic lipid peroxidation levels, triacylglycerol (TG) contents, antioxidant enzyme activities, and histopathological changes were examined for evaluating the hepatoprotective effects of lemon juice in mice. In addition, the in vitro antioxidant capacities of lemon juice were determined. The results showed that lemon juice significantly inhibited alcohol-induced increase of alanine transaminase (ALT), aspartate transaminase (AST), hepatic TG, and lipid peroxidation levels in a dose-dependent manner. Histopathological changes induced by alcohol were also remarkably improved by lemon juice treatment. These findings suggest that lemon juice has protective effects on alcohol-induced liver injury in mice. The protective effects might be related to the antioxidant capacity of lemon juice because lemon juice showed in vitro antioxidant capacity.

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Section: Discussioncontrasting

confidence: 40%

Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice

Zhou

Zhang

et al. 2017

BioMed Research International

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“…At the same time, the antioxidant enzymes, including sod1, gshpx, and gshrd, represent the defense response to excessive free radicals. The effects of alcohol exposure on the activity or content of antioxidant enzymes are rather controversial in the literature, depending on the model, diet, amount, and time of alcohol feeding [32][33][34][35][36].…”

mentioning

confidence: 99%

Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice

Chu

et al. 2020

Oxidative Medicine and Cellular Longevity

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Vitamin D deficiency has been reported in alcoholics. This study is aimed at evaluating the effects of vitamin D deficiency on chronic alcohol-induced liver injury in mice. Mice were fed with modified Lieber-DeCarli liquid diets for 6 weeks to establish an animal model of chronic alcohol-induced liver injury. In the VDD+EtOH group, mice were fed with modified diets, in which vitamin D was depleted. Vitamin D deficiency aggravated alcohol-induced liver injury. Furthermore, vitamin D deficiency aggravated hepatocyte apoptosis during alcohol-induced liver injury. Although it has a little effect on hepatic TG content, vitamin D deficiency promoted alcohol-induced hepatic GSH depletion and lipid peroxidation. Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1. By contrast, vitamin D deficiency attenuated alcohol-induced upregulation of hepatic antioxidant enzyme genes, such as superoxide dismutase (sod) 1 and gshpx. In addition, vitamin D deficiency significantly elevated alcohol-induced upregulation of hepatic proinflammatory cytokines and chemokines. Taken together, these results suggest that vitamin D deficiency aggravates hepatic oxidative stress and inflammation during chronic alcohol-induced liver injury.

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“…SOD (a metalloenzyme) converts superoxide anion to hydrogen peroxide, and CAT catalyzes then hydrogen peroxide into molecular oxygen and water. The effects of alcohol exposure on the activity or content of SOD and CAT are rather controversial in the literature, as the activity or content of SOD and CAT might increase, not change, or decrease, depending on the model, diet, amount, and time of alcohol feeding [13,24,28,29]. In this study, the activity of SOD was stimulated in the model with respect to the control group, but CAT decreased.…”

Section: Resultsmentioning

confidence: 65%

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Zhang

Zhou

Wang

et al. 2016

IJMS

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Previous studies have shown that fruits have different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three fruits and aimed at studying the effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on alcohol-induced liver injury in mice. The animals were treated daily with alcohol and fruit juices for fifteen days. Chronic treatment with alcohol increased the levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), and decreased total protein (TP). Histopathological evaluation also showed that ethanol induced extensive fat droplets in hepatocyte cytoplasm. Syzygium samarangense and Passiflora edulis normalized various biochemical parameters. Solanum muricatum increased the level of ALT and induced infiltration of inflammatory cells in the liver. These results strongly suggest that treatment with Syzygium samarangense and Passiflora edulis could protect liver from the injury of alcohol, while Solanum muricatum could aggravate the damage.

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Exposure to alcohol and tobacco smoke causes oxidative stress in rats

Abstract: The obtained results suggest that in the ethanol-addicted rats combined exposure to smoke and alcohol differentially modulate endogenous antioxidant defense system and reactions to oxidative stress.

Cited by 35 publications

References 42 publications

Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice

Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice

Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

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