Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice

Zhou, Tong; Zhang, Yujie; Xu, Dong-ping; Wang, Fang; Zhou, Yue; Zheng, Jie; Li, Ya; Zhang, Jiaojiao; Li, Hua-Bin

doi:10.1155/2017/7463571

Cited by 37 publications

(29 citation statements)

References 29 publications

(40 reference statements)

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“…Many dietary natural products possess the abilities to protect against liver diseases [ 18 , 19 , 20 ]. They have shown the potential in improving the integrity of the gut mucosa, modulating the composition of the microbiota, reducing the toxic metabolites and translocated bacteria in the liver [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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A variety of dietary natural products have shown hepatoprotective effects. Increasing evidence has also demonstrated that gut microorganisms play an important role in the hepatoprotection contributed by natural products. Gut dysbiosis could increase permeability of the gut barrier, resulting in translocated bacteria and leaked gut-derived products, which can reach the liver through the portal vein and might lead to increased oxidative stress and inflammation, thereby threatening liver health. Targeting gut microbiota modulation represents a promising strategy for hepatoprotection. Many natural products could protect the liver from various injuries or mitigate hepatic disorders by reverting gut dysbiosis, improving intestinal permeability, altering the primary bile acid, and inhibiting hepatic fatty acid accumulation. The mechanisms underlying their beneficial effects also include reducing oxidative stress, suppressing inflammation, attenuating fibrosis, and decreasing apoptosis. This review discusses the hepatoprotective effects of dietary natural products via modulating the gut microbiota, mainly focusing on the mechanisms of action.

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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“…If the liver tissue is injured, liver cell swelling and necrosis, or increased membrane permeability of liver cells will occur, followed by secretion of transaminase into the blood, contributing to the increase in serum transaminase activity. Because aminotransferase activity in the liver is much higher than that in the blood under normal conditions, its change in serum is a specific marker used to assess hepatocellular damage in clinic (22,27). Zhang et al (3) investigated the protective effect of anthocyanins from purple sweet potato on acute carbon tetrachloride-induced liver injury in mice, which showed that the anthocyanins could significantly reduce the carbon tetrachloride-induced ALT and AST activity, demonstrating its protective effect.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Letinous�edodes foot peptides against ethanol‑induced liver injury in L02 cells

Huo

Zhang

et al. 2018

Mol Med Report

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The aim of the present study was to evaluate the protective effect and mechanism of Letinous edodes foot peptides on ethanol‑induced L02 cells. A cell model of ethanol‑induced damage was established in vitro to study the effects of the Letinous edodes foot peptides on human L02 hepatocytes. The expression and activity of superoxide dismutase (SOD), malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), following treatment were examined to determine the anti‑alcoholism and hepatoprotective functions of Letinous edodes foot peptides. Taking Letinous edodes foot peptides prior to ethanol exposure was more beneficial, which significantly increased SOD activity and the mRNA expression of ADH and ALDH suppressed by ethanol. In addition, the intracellular MDA content, and AST and ALT activity decreased in ethanol‑induced L02 cells pretreated with the peptides, when compared with the control. Furthermore, Letinous edodes foot peptides inhibited the ethanol‑induced activation of the proinflammatory cytokines, interleukin‑6 and tumor necrosis factor‑α, and promoted the metabolic regulation factors, AMP‑activated protein kinase‑α2 and peroxisome proliferator‑activated receptor‑α.

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“…Some natural products have been found to protect against liver injuries [166][167][168][169][170]. Tea has also shown a beneficial effect on diet-and chemical-induced disorders in liver, including hepatic oxidative stress damage, inflammation, steatosis, and fibrosis [41,171,172].…”

Section: Hepato-protective Effectmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

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242

150

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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Protective Effects of Lemon Juice on Alcohol-Induced Liver Injury in Mice

Cited by 37 publications

References 29 publications

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Protective effect of Letinous�edodes foot peptides against ethanol‑induced liver injury in L02 cells

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

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