The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Zhang, Yujie; Zhou, Tong; Wang, Fang; Zhou, Yue; Li, Ya; Zhang, Jiaojiao; Zheng, Jie; Xu, Dong-ping; Li, Hua-Bin

doi:10.3390/ijms17101616

Cited by 40 publications

(22 citation statements)

References 39 publications

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“…Many natural products were demonstrated beneficial impacts on ALD and the gut microbiota has been found participating in the mechanisms of hepatoprotection ( Figure 1 and Figure 2 ) [ 76 , 77 , 78 ]. Flaxseed oil, for instance, was observed to relieve ALD in mice by reducing inflammatory cytokines and modulating gut dysbiosis [ 24 ].…”

Section: Alcoholic Liver Disease (Ald)mentioning

confidence: 99%

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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A variety of dietary natural products have shown hepatoprotective effects. Increasing evidence has also demonstrated that gut microorganisms play an important role in the hepatoprotection contributed by natural products. Gut dysbiosis could increase permeability of the gut barrier, resulting in translocated bacteria and leaked gut-derived products, which can reach the liver through the portal vein and might lead to increased oxidative stress and inflammation, thereby threatening liver health. Targeting gut microbiota modulation represents a promising strategy for hepatoprotection. Many natural products could protect the liver from various injuries or mitigate hepatic disorders by reverting gut dysbiosis, improving intestinal permeability, altering the primary bile acid, and inhibiting hepatic fatty acid accumulation. The mechanisms underlying their beneficial effects also include reducing oxidative stress, suppressing inflammation, attenuating fibrosis, and decreasing apoptosis. This review discusses the hepatoprotective effects of dietary natural products via modulating the gut microbiota, mainly focusing on the mechanisms of action.

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Section: Alcoholic Liver Disease (Ald)mentioning

confidence: 99%

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Meng

et al. 2018

Nutrients

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“…At the same time, the antioxidant enzymes, including sod1, gshpx, and gshrd, represent the defense response to excessive free radicals. The effects of alcohol exposure on the activity or content of antioxidant enzymes are rather controversial in the literature, depending on the model, diet, amount, and time of alcohol feeding [32][33][34][35][36].…”

mentioning

confidence: 99%

Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice

Chu

et al. 2020

Oxidative Medicine and Cellular Longevity

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Vitamin D deficiency has been reported in alcoholics. This study is aimed at evaluating the effects of vitamin D deficiency on chronic alcohol-induced liver injury in mice. Mice were fed with modified Lieber-DeCarli liquid diets for 6 weeks to establish an animal model of chronic alcohol-induced liver injury. In the VDD+EtOH group, mice were fed with modified diets, in which vitamin D was depleted. Vitamin D deficiency aggravated alcohol-induced liver injury. Furthermore, vitamin D deficiency aggravated hepatocyte apoptosis during alcohol-induced liver injury. Although it has a little effect on hepatic TG content, vitamin D deficiency promoted alcohol-induced hepatic GSH depletion and lipid peroxidation. Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1. By contrast, vitamin D deficiency attenuated alcohol-induced upregulation of hepatic antioxidant enzyme genes, such as superoxide dismutase (sod) 1 and gshpx. In addition, vitamin D deficiency significantly elevated alcohol-induced upregulation of hepatic proinflammatory cytokines and chemokines. Taken together, these results suggest that vitamin D deficiency aggravates hepatic oxidative stress and inflammation during chronic alcohol-induced liver injury.

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“…AST and ALT are aminopherases concentrating in hepatocyte cytoplasm which will leak into plasma as hepatocytes are damaged by alcohol and its metabolites [ 21 ]. The impairment of hepatic conjugated bilirubin excretion causes the increase of serum TBIL, which reflects the functional lesion of the liver [ 22 ]. As shown in Table 4 , the liver index ( p < 0.01) and serum levels of AST ( p < 0.01), ALT ( p < 0.05), TBIL ( p < 0.05), and serum TG ( p < 0.05) were increased significantly in the model group compared with the control group, which indicated the liver injury induced by alcohol.…”

Section: Resultsmentioning

confidence: 99%

Five-Golden-Flowers Tea: Green Extraction and Hepatoprotective Effect against Oxidative Damage

et al. 2018

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The consumption of herbal teas has become popular in recent years due to their attractive flavors and outstanding antioxidant properties. The Five-Golden-Flowers tea is a herbal tea consisting of five famous edible flowers. The effects of microwave-assisted extraction parameters on the antioxidant activity of Five-Golden-Flowers tea were studied by single-factor experiments, and further investigated using response surface methodology. Under the optimal parameters (53.04 mL/g of solvent/material ratio, 65.52 °C, 30.89 min, and 500 W), the ferric-reducing antioxidant power, Trolox equivalent antioxidant capacity, and total phenolic content of the herbal tea were 862.90 ± 2.44 µmol Fe2+/g dry weight (DW), 474.37 ± 1.92 µmol Trolox/g DW, and 65.50 ± 1.26 mg gallic acid equivalent (GAE)/g DW, respectively. The in vivo antioxidant activity of the herbal tea was evaluated on alcohol-induced acute liver injury in mice. The herbal tea significantly decreased the levels of aspartate aminotransferase, total bilirubin, and malonaldehyde at different doses (200, 400, and 800 mg/kg); improved the levels of liver index, serum triacylglycerol, and catalase at dose of 800 mg/kg. These results indicated its role in alleviating hepatic oxidative injury. Besides, rutin, chlorogenic acid, epicatechin, gallic acid, and p-coumaric acid were identified and quantified by high performance liquid chromatography (HPLC), which could contribute to the antioxidant activity of the herbal tea.

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The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Cited by 40 publications

References 39 publications

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice

Five-Golden-Flowers Tea: Green Extraction and Hepatoprotective Effect against Oxidative Damage

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