Exposure to 17α-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio)

Xu, Hui; Yang, Jian; Wang, Yuexiang; Qiu, Jian; Chen, Hao; Song, Houyan

doi:10.1016/j.aquatox.2008.01.020

Cited by 122 publications

(69 citation statements)

References 28 publications

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“…When the concentration was increased to 10 ng L −1 was observed a significantly decrease in the weight and length body. On the other hand, 180 days post-hatch were found abnor-mal testicular morphologies in male fish, namely malformations of the sperm duct, an altered proportion of germ cell types, and a reduced number of spermatozoa, for those levels of EE2 [152]. Exposure of male roach to EE2 concentrations up to 4 ng L −1 in early life disrupted normal sexual development causing a femi-nized response, characterized by the presence of an ovarian cavity and induced plasma vitellogenin production [153].…”

Section: Sex Hormonesmentioning

confidence: 96%

“…Sex reversal was complete at levels of 2 ng L −1 [150]. Xu et al [152] also exposed zebrafish to EE2 during their period of sex differentiation, show-ing that, after 90 days posthatch, there was already an increase in mortality rate and sex ratio for fish exposed to concentrations of 2 ng L −1 . When the concentration was increased to 10 ng L −1 was observed a significantly decrease in the weight and length body.…”

Section: Sex Hormonesmentioning

confidence: 99%

See 1 more Smart Citation

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,240

533

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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Section: Sex Hormonesmentioning

confidence: 96%

Section: Sex Hormonesmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,240

533

View full text Add to dashboard Cite

show abstract

“…In contrast to these findings, Nash et al [33] exposed 1 dpf zebrafish to 0.5 or 5 ng/L EE2 for 75 d and then allowed them to recover for 150 d. At the end of the recovery period, male fish exhibited histological alterations in the testis, including extensive sperm duct malformations, presence of ovarian cavities, variations in the frequency of testicular cell types, and ciliation of sperm ducts. Xu et al [34] exposed 2 dpf zebrafish to 0.4, 2, and 10 ng/L EE2 for 88 d followed by a recovery period of 90 d. Exposure to 2 and 10 ng/L EE2 resulted in a significant increase in the number of fish containing ovarian or undifferentiated tissue at the end of the exposure period. Although no significant differences in sex ratios were seen after the recovery period, a significant percentage of males exhibited malformations of the sperm duct, altered proportions of germ cell types, and reduced number of spermatozoa.…”

Section: Accommodation and Recovery Of Endocrine Systemsmentioning

confidence: 97%

“…Interestingly, although most of these studies demonstrated that fish can partially or fully recover based on gonadal histology and fecundity tests (as assessed by female egg production), most efforts showed that short-or long-term EE2 exposure can result in long-term impacts on male fertility (as assessed by fertilization success [32][33][34]36,37]). Thus, these studies highlight the importance of endpoint selection for evaluation of recovery and illustrate the importance of assessing potential fitness costs associated with chemically mediated disruption of the HPG axis.…”

Section: Accommodation and Recovery Of Endocrine Systemsmentioning

confidence: 97%

Predicting chemical impacts on vertebrate endocrine systems

Nichols

Breen

Denver

et al. 2010

Enviro Toxic and Chemistry

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Animals have evolved diverse protective mechanisms for responding to toxic chemicals of both natural and anthropogenic origin. From a governmental regulatory perspective, these protective responses complicate efforts to establish acceptable levels of chemical exposure. To explore this issue, we considered vertebrate endocrine systems as potential targets for environmental contaminants. Using the hypothalamic-pituitary-thyroid (HPT), hypothalamic-pituitary-gonad (HPG), and hypothalamic-pituitary-adrenal (HPA) axes as case examples, we identified features of these systems that allow them to accommodate and recover from chemical insults. In doing so, a distinction was made between effects on adults and those on developing organisms. This distinction was required because endocrine system disruption in early life stages may alter development of organs and organ systems, resulting in permanent changes in phenotypic expression later in life. Risk assessments of chemicals that impact highly regulated systems must consider the dynamics of these systems in relation to complex environmental exposures. A largely unanswered question is whether successful accommodation to a toxic insult exerts a fitness cost on individual animals, resulting in adverse consequences for populations. Mechanistically based mathematical models of endocrine systems provide a means for better understanding accommodation and recovery. In the short term, these models can be used to design experiments and interpret study findings. Over the long term, a set of validated models could be used to extrapolate limited in vitro and in vivo testing data to a broader range of untested chemicals, species, and exposure scenarios. With appropriate modification, Tier 2 assays developed in support of the U.S. Environmental Protection Agency's Endocrine Disruptor Screening Program could be used to assess the potential for accommodation and recovery and inform the development of mechanistically based models.

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“…The study performed in zebra fish showed that there is an increased mortality rate and sex ratio through the exposure of 2 ng L -1 , and continuous exposure results in the significant reduction in the weight and length of body (Xu et al 2008).…”

Section: The Ecotoxicity Of the Selected Pharmaceutically Active Compmentioning

confidence: 98%

Degradation of pharmaceuticals by ultrasound-based advanced oxidation process

2016

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Water pollution by pharmaceutically active compounds is an emerging issue. Toxicological studies reveal that pharmaceuticals are indeed toxic for living organisms. The lack of suitable treatment technology for the complete removal of pharmaceuticals is therefore a major challenge. Advanced oxidation processes are emerging removal techniques that have many advantages versus conventional technologies. Many studies indicate that advanced oxidation processes, either in single or in combination with other degradation techniques, can enhance the degradation of pharmaceuticals in aqueous solutions. Here, we review the degradation of pharmaceuticals by sonolysis, an oxidation processes using ultrasound. In this technique, hydroxyl radicals are generated by pyrolytic cleavage of water molecules. We review the influence of operational parameters, additives and hybrid techniques on the degradation of pharmaceuticals. The maximum degradation of organic compounds was observed in the frequency range of 100-1000 kHz, which is in the high-frequency medium-power ultrasound. Even though almost all the experiments presented more than 90 % removal and good biodegradability of the target compound, good mineralization and the toxicity removal were hardly achieved. The efficiency of the degradation varies with water matrixes and varying pH. Major pathways of degradation are hydroxylation, dehalogenation, demethylation, decarboxylation, deamination, etc. More hybrid techniques have to be developed to scale up the application of ultrasound.

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Exposure to 17α-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio)

Cited by 122 publications

References 28 publications

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Predicting chemical impacts on vertebrate endocrine systems

Degradation of pharmaceuticals by ultrasound-based advanced oxidation process

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