Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos, Lúcia H.M.L.M.; Araújo, Alberto N.; Fachini, Adriano; Pena, Angelina; Delerue–Matos, Cristina; Montenegro, M.C.B.S.M.

doi:10.1016/j.jhazmat.2009.10.100

Cited by 1,223 publications

(582 citation statements)

References 207 publications

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“…A grande maioria dos estudos envolvendo o descarte de medicamentos apontam os AINEs, hormônios e psicoativos como as principais classes encontradas no ecossistema analisado. Segundo estudo conduzido por Santos et al (2010), os AINES, seguido pelos antibióticos, agentes dislipidêmicos e hormônios são as principais classes envolvidas em episódios de contaminação do ambiente por químicos de utilização terapêutica. Porém, se extrapolarmos a quantidade do laboratório de hormônio, que obteve o menor índice nos testes executados, para a mesma quantidade de formulações do laboratório de sólidos teríamos, para as análises de hormônios, 25,79% de inibição de r-value reforçando a hipótese do laboratório de sólido possuir a menor taxa de impacto ambiental dentre as demais classes analisadas.…”

Section: Resultsunclassified

Toxicidade ambiental de efluentes advindo de diferentes laboratórios de uma farmácia magistral

Pinto¹,

Cardozo²,

Soares³

et al. 2016

Rev. ambiente água

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RESUMOHá uma crescente preocupação com os chamados "poluentes emergentes" na produção de medicamentos. Eles chegam ao meio ambiente a partir do descarte doméstico ou a partir das sobras geradas na produção de fármacos. Em pequenas concentrações da ordem de microgramas por litro ou inferiores, ou seja, concentrações não efetivas a curto prazo em termos de resposta biológica em seres humanos, podem causar grandes impactos no meio ambiente pela exposição crônica. O objetivo deste trabalho foi avaliar o risco de contaminação de efluentes pelo lançamento dos dejetos brutos da produção de medicamentos em pequena escala, por farmácias de manipulação, com base na avaliação da ecotoxicicidade pelo biomonitoramento de algas Euglena gracilis, e investigar os impactos apresentados sobre o comportamento e as alterações no processo de fotossíntese. Amostras de quatro laboratórios de diferentes demandas foram analisadas. As alterações comportamentais (velocidade de subida à superfície, r-value e velocidade de movimento) das algas foram biomonitoradas pelo NG-TOX e os parâmetros de fotossíntese foram medidos com o fluorímetro de pulso e amplitude modulada (PAM). Os resultados demonstraram que o efluente do laboratório de hormônios, que teve uma baixa produção semestral, apresentou pouco impacto, já o efluente do laboratório de psicotrópicos, mesmo com demanda intermediária, apresentou impacto significante sobre o comportamento e a atividade fotossintética das algas. A diferença de comportamento observada entre os diferentes setores de fármacos demonstra que os impactos e os possíveis riscos ambientais são diferentes para cada setor. A demanda e as diferentes substâncias manipuladas podem ser determinantes na classificação de risco e na escolha dos métodos de descontaminação.Palavras-chave: biomonitoramento, descarte de medicamentos, ecotoxicidade, poluentes emergentes. Environmental toxicity of effluents of different laboratories of a compounding pharmacy ABSTRACTThere is a growing concern over so-called "emerging pollutants" in the production of pharmaceuticals. These pollutants reach the environment from household waste or from

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Section: Resultsunclassified

Toxicidade ambiental de efluentes advindo de diferentes laboratórios de uma farmácia magistral

Pinto¹,

Cardozo²,

Soares³

et al. 2016

Rev. ambiente água

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“…At the same time, point-source pollution from wastewater, waste management, industry and contaminated land has also potentially increased. As a result, pesticides, pharmaceuticals (Leston et al, 2011;Santos et al, 2010), endocrine disruptors (Baptista et al, 2013;Nunes et al, 2011;Ribeiro et al, 2009), metals (Couto et al, 2013), organic material, salt, ammonia and other urban contaminants might have increased in the system, though treatment plants can be successful in removing some of them (EPA, 2010). Such alterations in the type and pattern of LULC driving forces could have implications not only on future management policies, but also on monitoring plans and on the selection of biological indicators.…”

Section: Lulc As Driving Forces and Dynamics Over The Yearsmentioning

confidence: 99%

Systematic processes of land use/land cover change to identify relevant driving forces: Implications on water quality

Teixeira

Marques

2014

Science of The Total Environment

110

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• LULC and LULC changes are important drivers of water condition.• We identified strong signals of systematic transitions.• Consistency and magnitude of systematic transitions reveal processes of LULC change.• Processes of LULC change reveal important drivers of water condition.• Relevant drivers reveal potential pressures linked to the process of transition. Land use and land cover (LULC) are driving forces that potentially exert pressures on water bodies, which are most commonly quantified by simply obtained aggregated data. However, this is insufficient to detect the drivers that arise from the landscape change itself. To achieve this objective one must distinguish between random and systematic transitions and identify the transitions that show strong signals of change, since these will make it possible to identify the transitions that have evolved due to population growth, industrial expansion and/or changes in land management policies. Our goal is to describe a method to characterize driving forces both from LULC and dominant LULC changes, recognizing that the presence of certain LULC classes as well as the processes of transition to other uses are both sources of stress with potential effects on the condition of water bodies. This paper first quantifies the driving forces from LULC and also from processes of LULC change for three nested regions within the Mondego river basin in 1990, 2000 and 2006. It then discusses the implications for the environmental water body condition and management policies. The fingerprint left on the landscape by some of the dominant changes found, such as urbanization and industrial expansion, is, as expected, low due to their proportion in the geographic regions under study, yet their magnitude of change and consistency reveal strong signals of change regarding the pressures acting in the system. Assessing dominant LULC changes is vital for a comprehensive study of driving forces with potential impacts on water condition.

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“…The synthetic compound sulfamethoxazole (SMX) is one of the most popularly prescribed and consumed sulfonamide antibiotics (Cavallucci 2007;Hruska and Franek 2012) leading to its presence in the aquatic environment via WW discharge (Avisar et al 2009;Santos et al 2010) and its frequent detection in WWs at up to microgram-per-liter levels and surface waters at nanogram-per-liter levels (Batt et al 2007;Joss et al 2005;Kolpin et al 2002;Miège et al 2009;Peng et al 2006;Yargeau et al 2007;Gao et al 2012a). At these concentrations, SMX has been found to be mutagenic but not acutely toxic to Vibrio fisheri and Daphnia magna (Isidori et al 2005) and to be phytotoxic to algae (García-Galán et al 2011) and other plant species (Hillis et al 2011).…”

Section: Smx Usage and Presence In The Environmentmentioning

confidence: 99%

Biodegradation of sulfamethoxazole: current knowledge and perspectives

Larcher

Yargeau

2012

Appl Microbiol Biotechnol

113

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Antibiotic compounds, like sulfamethoxazole (SMX), have become a concern in the aquatic environment due to the potential development of antibacterial resistances. Due to extensive consumption, excretion and disposal, SMX has been frequently detected in wastewaters and surface waters. This has led to numerous studies investigating the nature of SMX, with many researchers focusing on the biodegradation and persistence of SMX during wastewater treatment and in the environment. This review provides a summary of recent developments, outlines the discrepancies in observations and results, and demonstrates the need for further research to determine optimal biological removal strategies for SMX and other antibiotics.

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Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Cited by 1,223 publications

References 207 publications

Toxicidade ambiental de efluentes advindo de diferentes laboratórios de uma farmácia magistral

Toxicidade ambiental de efluentes advindo de diferentes laboratórios de uma farmácia magistral

Systematic processes of land use/land cover change to identify relevant driving forces: Implications on water quality

Biodegradation of sulfamethoxazole: current knowledge and perspectives

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