Exposure of Candida parapsilosis complex to agricultural azoles: An overview of the role of environmental determinants for the development of resistance

Brilhante, Raimunda Sâmia Nogueira; Alencar, Lucas Pereira de; Bandeira, Silviane Praciano; Sales, Juscelino Chaves; Evangelista, Antonio José de Jesus; Serpa, Rosana; Cordeiro, Rossana de Aguiar; Pereira-Neto, Waldemiro de Aquino; Sidrim, José Júlio Costa; Castelo-Branco, Débora de Souza Collares Maia; Rocha, Marcos Fábio Gadelha

doi:10.1016/j.scitotenv.2018.09.096

Cited by 23 publications

(19 citation statements)

References 38 publications

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“…There are different resistance mechanisms but resistance to azole antifungal drugs is mostly due to modi cations in the target enzyme as a result of mutations (Balkan et al, 2019;Brilhante et al, 2019). Low access of azole drugs to the target site is also due to the over-expression of the ERG11 gene.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antifungal Susceptibility Pattern of Candida Isolates from Women with Recurrent Vulvovaginal Candidiasis in Ghana - A Review of Laboratory Reports.

Pesewu

Feglo

Boateng

et al. 2020

Preprint

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Vulvovaginal candidiasis (VVC) is a common infection among women of childbearing age, and few of these women experience recurrent vulvovaginal candidiasis (RVVC). The study was aimed at determining the virulent factors, and antifungal susceptibility of the Candida species isolated from women with RVVC attending the Nkawie Government Hospital, Ashanti-Region, Ghana. Over a 6–month period (October 2016 to March 2017), a total of 288 women with RVVC were evaluated. Isolation of the yeast was performed after the inoculation of the vaginal specimens onto Sabouraud Dextrose Agar (SDA), and incubated for 24-48 hours at 37oC. The isolates were identified by standardized conventional methods. The enzymatic activities of esterase, phospholipase, haemolysis and biofilm production were evaluated for the identification of the yeast isolates. Susceptibility to antifungal agents was determined by using the Kirby-Bauer disk diffusion method. Azole resistant isolates were further tested for ERG11 gene which encodes the enzyme (cytochrome P450 lanosterol 14-α-demethylase) by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Vaginal swabs cultures of 200 women (64.4) from 288 samples yielded Candida species. Candida albicans was the commonest isolated specie (33.0%), followed by Candida glabrata (29.5 %), Candida tropicalis (23.0%), and Candida krusei (15.5%). Hemolysin production, phospholipase enzyme activity, and biofilms formation were found in 84.5%, 83%, 77.5%.of the isolates respectively. Most phospholipase producing Candida isolates also formed biofilms. All Candida spp isolated were susceptible to itraconazole while majority of them were resistant to voriconazole. ERG11 genes were detected in 11.1% of Azole resistant Candida species. There is a significant increase in the rate of antifungal resistance among the Candida isolates to fluconazole and voriconazole. There is need for continuous surveillance as well as antifungal susceptibility testing on the Candida spp to guide therapy. A larger epidemiological study is also advocated to determining the degree of spread of ERG11 genes.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Antifungal Susceptibility Pattern of Candida Isolates from Women with Recurrent Vulvovaginal Candidiasis in Ghana - A Review of Laboratory Reports.

Pesewu

Feglo

Boateng

et al. 2020

Preprint

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“…No presente estudo, 50% dos isolados foram classificados como formadores de biofilme. Os resultados da atividade metabólica de biofilmes de C. parapsilosis (latu sensu) podem ser difíceis de discutir devido à alta variabilidade intrínseca, e o fato de que a atividade metabólica não reflete necessariamente a quantidade de biomassa (BRILHANTE et al, 2019). Quando em biofilmes, a maioria dos isolados clínicos foi resistente aos antifúngicos testados, considerando-se os valores de pontos de corte determinados pelo CLSI para células planctônicas, já que não há, até o momento, valores estabelecidos para biofilmes fúngicos.…”

Section: Discussionunclassified

CARACTERIZAÇÃO ANATÔMICA E HISTOQUÍMICA DA LÂMINA FOLIAR DE Calotropis procera (Aiton) W.T.Aiton

Sá¹,

Silva²,

Santos³

et al. 2019

Biomedicina E Farmácia: Aproximações 2

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“…Fungal infections may not be an imminent danger to otherwise healthy people, however, the increasing number of immunocompromised people and the occurrence of environmental azole-resistant fungi may lead to an increasing risk of fungal infections. Previous studies have shown the relation between the use of azole and the development of medical azole-resistant Aspergillus fumigatus, Candida glabrata, and Candida parasilopsis complex (Brilhante et al, 2019;Faria-Ramos et al, 2014;Snelders et al, 2012) which may lead to the presence of medical azole-resistant fungi in the environment (Snelders et al, 2009). Azole is used in many products related to plant protection, and in coatings, paints, and wall paper pastes for material preservation.…”

Section: Human Exposure To Contaminants and Health Risksmentioning

confidence: 99%

Protection of Public Health from Microbial and Chemical Hazards in Swimming Pool Environments

Ekowati¹

2019

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Ozone is a very powerful chemical disinfectant which is able to oxidize organic and inorganic compounds, as well as killing microorganisms. The high oxidizing power is due to the weak bonds of the third oxygen atom causing instability of the ozone molecule. Ozone decomposes rapidly and thus does not provide a residual disinfection effect and has to be generated on-demand at the site of application. Ozone is a stronger oxidant than chlorine, with a higher redox potential (WHO, 2000). In aqueous solution, ozone reacts with organic and inorganic compounds by means of two different mechanisms: direct oxidation by ozone molecules and oxidation by hydroxyl radicals during ozone decomposition (Glaze et al., 1987; Gottschalk et al., 2010; CHAPTER 1 | 5 are applied in drinking water treatment as advanced oxidation processes (AOPs), usually combined with hydrogen peroxide and ozone (Heering, 2004). Contaminants in swimming pools and similar environments Figure 2. Potential microbial and chemical hazards in swimming pools and similar environments (adapted from WHO (2006)) Microbial hazards Microbial contaminants in the pool water can be pathogens originating from faecal matter introduced by humans and animals, from human shedding (e.g. vomit, mucus, saliva, and skin) (WHO, 2006) or from source water and air (Figure 2). Many outbreaks associated with pathogens in swimming pools and similar environments have been reported worldwide (

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Exposure of Candida parapsilosis complex to agricultural azoles: An overview of the role of environmental determinants for the development of resistance

Cited by 23 publications

References 38 publications

Prevalence and Antifungal Susceptibility Pattern of Candida Isolates from Women with Recurrent Vulvovaginal Candidiasis in Ghana - A Review of Laboratory Reports.

Prevalence and Antifungal Susceptibility Pattern of Candida Isolates from Women with Recurrent Vulvovaginal Candidiasis in Ghana - A Review of Laboratory Reports.

CARACTERIZAÇÃO ANATÔMICA E HISTOQUÍMICA DA LÂMINA FOLIAR DE Calotropis procera (Aiton) W.T.Aiton

Protection of Public Health from Microbial and Chemical Hazards in Swimming Pool Environments

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