Exposition aux gaz d’échappement diesel durant la gestation : quelles conséquences sur le développement foeto-placentaire ? Apport des modèles animaux

Valentino, Sarah; Tarrade, Anne; Chavatte‐Palmer, Pascale

doi:10.4267/2042/61628

Cited by 4 publications

(3 citation statements)

References 50 publications

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“…In France, a diesel reference country, the number of deaths due to pollution ranges between 17,000 and 48,000, thus representing an economic cost of approximately 33.6 billion US dollars [2]. Diesel gas emissions in the gaseous phase comprise several toxic gases, including nitrogen dioxide (NO 2 ) and carbon monoxide (CO) [3]. In Benin, the inhalation of car pollutants due to the relatively long duration induces respiratory disorders [4] in motorcycle taxi drivers exposed to a CO concentration greater than nine (09) ppm [5].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Responses of Wistar Rats Exposed to Controlled Emissions of Carbon Monoxide and Nitrogen Dioxide

Tito¹,

Messan²,

Togbenou³

et al. 2019

World Journal of Research and Review

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The inhalation of pollutants of automobile origin induces blood disturbances, especially noncommunicable diseases, in humans. However, there are no studies highlighting the effects induced by car pollutants. From this perspective, this study aims to evaluate the effects of at least two (02) pollutants, carbon monoxide (CO) and nitrogen dioxide (NO 2), on oxidative stress and inflammation after a single exposure for four hours (04 h). Materials and methods: Ten male Wistar strain rats were randomly divided into two groups of five (05): the control group (179.00 ± 5.916 g) unexposed and the group exposed to CO and NO 2 (188.00 ± 13.13 g). CO and NO 2 were produced by the combustion gas oil using a device contained in a sealed metal box supplied with ambient air by a pump. The ranges of CO and NO 2 concentrations to which the rats were exposed varied between 35 and 45 ppm and between 0.2 and 0.3 ppm, respectively. The blood samples were taken at 24 hours after the end of the manipulations. A malondialdehyde (MDA) assay was performed on supernatant using the GENESYS 10S UV Visible Spectrophotometer. Tumour Necrosis factor alpha (TNF-α) levels in the supernatant stored at-80 ° C were examined with an ELISA kit. Results: The mean values of MDA (17,771 ± 6.624 nM / ml) and TNF-α (83,050 ± 7.483 μg / ml) observed in the exposed group were significantly higher (p ˂ 0.01) than those recorded in the control group (MDA (7.097 ± 1.882 nM / ml) and TNF-α (6.410 ± 3.160 μg / ml). Conclusion: Exposure to CO and NO 2 for at least 4 hours induces the overproduction of reactive oxygen species (ROS) and the exacerbation of inflammation.

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Section: Introductionmentioning

confidence: 99%

Toxicological Responses of Wistar Rats Exposed to Controlled Emissions of Carbon Monoxide and Nitrogen Dioxide

Tito¹,

Messan²,

Togbenou³

et al. 2019

World Journal of Research and Review

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“…According to the World Health Organisation, in 2016, household and ambient air pollution were responsible for seven million deaths [ 1 ]. During the last decade, many researchers have investigated both indoor and outdoor air quality monitoring systems because of air quality being intrinsically linked to human health [ 2 , 3 , 4 , 5 , 6 ] and the occurrence of premature deaths [ 7 , 8 , 9 , 10 ]. Therefore, having widespread, unattended portable and connected devices and networks for air quality monitoring and pollutant detection would be a decisive step forward for decreasing the prevalence of lethal diseases such as ischemic heart disease, stroke, chronic obstructive pulmonary disease, or even lung cancer [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

LoRa Sensor Network Development for Air Quality Monitoring or Detecting Gas Leakage Events

González

Casanova-Cháfer

Romero

et al. 2020

Sensors

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During the few last years, indoor and outdoor Air Quality Monitoring (AQM) has gained a lot of interest among the scientific community due to its direct relation with human health. The Internet of Things (IoT) and, especially, Wireless Sensor Networks (WSN) have given rise to the development of wireless AQM portable systems. This paper presents the development of a LoRa (short for long-range) based sensor network for AQM and gas leakage events detection. The combination of both a commercial gas sensor and a resistance measurement channel for graphene chemoresistive sensors allows both the calculation of an Air Quality Index based on the concentration of reducing species such as volatile organic compounds (VOCs) and CO, and it also makes possible the detection of NO2, which is an important air pollutant. The graphene sensor tested with the LoRa nodes developed allows the detection of NO2 pollution in just 5 min as well as enables monitoring sudden changes in the background level of this pollutant in the atmosphere. The capability of the system of detecting both reducing and oxidizing pollutant agents, alongside its low-cost, low-power, and real-time monitoring features, makes this a solution suitable to be used in wireless AQM and early warning systems.

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“…In this sense, the number of pollution-related deaths in France, the reference country for diesel, varies between 17,000 and 48,000 representing a significant economic cost of about 33.6 billion US dollars [3]. According to Valentino et al [4], several toxic gases, including nitrogen dioxide (NO2) and carbon monoxide (CO) are emitted by the diesel engine.…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic training on oxidative stress and inflammation in rats exposed to controlled emissions of carbon monoxide (CO) and nitrogen dioxide (NO2)

Tito¹,

Nsompi²,

Messan³

et al. 2020

World J. Adv. Res. Rev.

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The objective of this study is to determine the effects of isolated exercise and those of repeated exercise on oxidative stress and the inflammatory process following exposure to carbon monoxide (CO) and nitrogen dioxide (NO2). Material and Method: 15 male Wistar rats, all eight weeks old, were randomly assigned to three groups. CO and NO2 were produced by the combustion of diesel fuel using a device contained in a sealed metal box and supplied with ambient air by a pump. The ranges of CO and NO2 concentrations to which the rats were exposed ranged from 35 to 45 ppm and 0.2 to 0.3 ppm, respectively. The aerobic workouts were performed on a rat treadmill. Blood samples were taken 24 hours after completion of handling at D4, D9 and D14. Variables studied were Malondialdehyde (MDA) and Tumor Necrosis Factor-alpha (TNF-α). Results: Aerobic endurance training after repeated exposure to CO and NO2 induces at the end of the first training block (D4) a significant increase (p ˂ 0.01) in MDA and TNF-α. On the other hand, the second block (D9) and the third training block (D14) induced a significant decrease (p ˂ 0.01) in these same parameters. Conclusion: Aerobic exercise practiced in isolation exacerbates the oxidative stress and inflammation induced by exposure to CO and NO2. On the other hand, regular aerobic exercise in a less polluted environment, following five days of recovery, significantly reduces the high levels of oxidative stress and inflammation caused by repeated exposure to automobile pollutants.

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Exposition aux gaz d’échappement diesel durant la gestation : quelles conséquences sur le développement foeto-placentaire ? Apport des modèles animaux

Cited by 4 publications

References 50 publications

Toxicological Responses of Wistar Rats Exposed to Controlled Emissions of Carbon Monoxide and Nitrogen Dioxide

Toxicological Responses of Wistar Rats Exposed to Controlled Emissions of Carbon Monoxide and Nitrogen Dioxide

LoRa Sensor Network Development for Air Quality Monitoring or Detecting Gas Leakage Events

Effects of aerobic training on oxidative stress and inflammation in rats exposed to controlled emissions of carbon monoxide (CO) and nitrogen dioxide (NO2)

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