Exploring variables associated with medication non-adherence in patients with type 2 diabetes mellitus

Abstract

Objective This study aims to assess medication adherence and explore its predictors in outpatients with type 2 diabetes. Method This cross-sectional study collected socio-demographics, disease-related information, and different biomedical variables for type 2 diabetes patients attending a Jordanian Diabetes center. The four-item medication adherence scale (4-IMAS) and the beliefs about medications questionnaire (BMQ) which includes necessity and concerns were used. Stepwise backward quartile regression models were conducted to evaluate variables associated with the Necessity and Concerns scores. Stepwise ordinal regression was conducted to evaluate variables associated with adherence. Results 287 diabetic patients participated in the study. Almost half of the participants (46.5%) reported moderate adherence and 12.2% reported low adherence. Significant predictors of the adherence were necessity score (OR = 14.86, p <0.01), concern score (OR = 0.36, p <0.05), and frequency of medication administration (OR = 0.88, p- <0.01). Education was a significant predictor of Necessity and Concerns scores (β = 0.48, -0.2, respectively). Conclusion Simplifying the medication regimen, emphasizing medication necessity and overcoming medication concerns should be targeted in future diabetes intervention programs to improve medication adherence and hence glycemic control among diabetic patients.

What Are the Factors Associated with Nonadherence to Medications in Patients with Chronic Diseases?

“…A study in Swedish patients with stroke revealed that nonadherent patients showed less common positive beliefs and more common negative beliefs toward their medications [30]. Furthermore, similar results were also reported when evaluating the association between beliefs about medications and adherence in specific populations, including diabetes mellitus [31], hypertension [32] and dyslipidemia [33].…”

Validation of the Arabic version of medication adherence report scale questionnaire and beliefs about medication -specific questionnaire: A factor analysis study

“…Similar to the other parts of the globe, the issue of non- adherence to medications in Jordanian chronically ill patients is challenging. Reported prevalence of non-adherence to medications ranged from 29.6%-64.2% in different clinical settings [ 7 , 8 , 11 , 12 ]. More specifically, adherence to medications in diseases like hypertension, dyslipidemia and diabetes mellitus were reported to be 81%, 73.2% and 58.7%, respectively [ 8 , 9 , 13 ].…”

“…Reported prevalence of non-adherence to medications ranged from 29.6%-64.2% in different clinical settings [ 7 , 8 , 11 , 12 ]. More specifically, adherence to medications in diseases like hypertension, dyslipidemia and diabetes mellitus were reported to be 81%, 73.2% and 58.7%, respectively [ 8 , 9 , 13 ]. Studies showed that low level of adherence is associated with several factors, such as patient, disease, and medication-related factors [ 14 ].…”

Hospitalización y mortalidad según adherencia al tratamiento farmacológico en pacientes con Diabetes Mellitus tipo 2

“…Respecto la causa de hospitalización y UCI, en pacientes con DMT2 los estudios han mostrado que las principales corresponden a sepsis de tejidos blandos, el síndrome coronario agudo, el accidente cerebrovascular y estados hipoglucémicos [33,34]; en este trabajo los resultados concuerdan con la literatura internacional [11,35], dejando ver que en el grupo no adherente predominan las complicaciones derivadas del curso natural de la enfermedad [28], mientras que entre los adherentes son derivadas de condiciones patológicas preexistentes no relacionadas directamente con DMT2 [24,32,36].…”