Exploring the Xylariaceae and its relatives

Suwannasai, Nuttika; Sangvichien, Ek; Phosri, Cherdchai; McCloskey, Sirirath; Wangsawat, Niwana; Thamvithayakorn, Pisit; Ruchikachorn, Nutthaporn; Thienhirun, Surang; Mekkamol, Sureewan; Sihanonth, Prakitsin; Whalley, M. A.; Whalley, A.J.S.

doi:10.1186/s40529-023-00389-6

Bot Stud

2023

DOI: 10.1186/s40529-023-00389-6

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Exploring the Xylariaceae and its relatives

Nuttika Suwannasai

Ek Sangvichien

Cherdchai Phosri

et al.

Abstract: The Xylariaceae and its relatives rank as one of the best-known members of the Ascomycota. They are now well recognized for their diversity, global distribution, ecological activities and their outstanding novel metabolites with wide ranging bioactivity.

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2024

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Cited by 2 publications

References 109 publications

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Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media

Sresuksai,

Sawadsitang,

Jantaharn

et al. 2024

Nat. Prod. Bioprospect.

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Bioactive compounds from the wood-decay fungus Xylaria cf. longipes SWUF08-81, cultivated in three different culture media (GM, YM and PDB), were isolated. Their structures and stereochemistry were deduced from spectroscopic and MS data analysis, together with quantum chemical calculations of 13C NMR chemical shifts and electronic circular dichroism (ECD) spectra. Five undescribed polyketides including dibenzofuran (1), mellein (2), dihydroisocoumarin (15), and two pyrans (16, 17), together with twenty-three compounds were determined. Compounds 18 and 20 were significantly toxic against cancer cell lines (HCT116, HT29, MCF-7 and HeLa) based on the MTT assay. Quantification by HPLC showed that 18 was produced three-fold higher in the broth of PDB than YM. These studies showed that the production of different compounds were primarily dependent on nutrition sources and it has given a starting point for the growth optimization conditions for the scaling up of bioactive compounds production. Graphical Abstract

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Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media

Sresuksai,

Sawadsitang,

Jantaharn

et al. 2024

Nat. Prod. Bioprospect.

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Engleromophilane, a new broad spectrum bioactive eremophilane-type sesquiterpene from Engleromyces sinensis fungus

Sresuksai,

Jantaharn,

Sangvichien

et al. 2024

Natural Product Research

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A new eremophilane sesquiterpene, named engleromophilane (1) together with known eremoxylarin E (2) and steroids (3-7) were isolated from the fungus Engleromyces sinensis culture. The structures were deduced by the analysis of spectroscopic and MS data, together with the comparison of calculated 13 C NMR chemical shifts and Electronic Circular Dichroism (ECD) spectra. Compound 1 showed cytotoxic effects against Hela, PC-3, HT29 and A549 cell lines with IC50 in the ranges of 4.84-9.48 μg/mL. Compounds 1 and 2 exhibited substantial antimicrobial activity against E. coli, S. aureus, and B. subtilis. Moreover, compounds 1-3 showed α-glucosidase inhibitory activity, in which 2 displayed a strong inhibitory effect with an IC50 value of 0.13 ± 0.01µg/mL. This work has given additional value to the E. sinensis fungus as a remarkable bioactive compound producer, together with the possibility of increasing cultivation to industrial scales.

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Exploring the Xylariaceae and its relatives

Abstract: The Xylariaceae and its relatives rank as one of the best-known members of the Ascomycota. They are now well recognized for their diversity, global distribution, ecological activities and their outstanding novel metabolites with wide ranging bioactivity.

Cited by 2 publications

References 109 publications

Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media

Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media

Engleromophilane, a new broad spectrum bioactive eremophilane-type sesquiterpene from Engleromyces sinensis fungus

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