Engleromophilane, a new broad spectrum bioactive eremophilane-type sesquiterpene from
Engleromyces sinensis
fungus
Kittiwan Sresuksai,
Phongphan Jantaharn,
Ek Sangvichien
et al.
Abstract:A new eremophilane sesquiterpene, named engleromophilane (1) together with known eremoxylarin E (2) and steroids (3-7) were isolated from the fungus Engleromyces sinensis culture. The structures were deduced by the analysis of spectroscopic and MS data, together with the comparison of calculated 13 C NMR chemical shifts and Electronic Circular Dichroism (ECD) spectra. Compound 1 showed cytotoxic effects against Hela, PC-3, HT29 and A549 cell lines with IC50 in the ranges of 4.84-9.48 μg/mL. Compounds 1 and 2 e… Show more
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