Exploring the universal healthy human gut microbiota around the World

Piquer-Esteban, Samuel; Ruiz-Ruiz, Susana; Arnau, Vicente; Díaz, Wladimiro; Moya, Andrés

doi:10.1016/j.csbj.2021.12.035

Cited by 26 publications

(19 citation statements)

References 117 publications

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“…Here, as has been previously observed in the gut and oral microbiome (McDonald et al, 2015;Piquer-Esteban et al, 2022;Valles-Colomer et al, 2023), cultural variations, such as dietary habits, might be of great importance to understand such differences, given that Chile is one of the most westernized countries of South America, and Spain and Belgium are fully westernized European countries (Conceição et al, 2020).…”

Section: Discussionmentioning

confidence: 66%

Comparative 16S rRNA gene sequencing study of subgingival microbiota of healthy subjects and patients with periodontitis from four different countries

Arredondo

Álvarez

Isabal

et al. 2023

J Clinic Periodontology

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AimTo investigate the differences between the subgingival microbiota of healthy subjects (HS) and periodontitis patients (PP) from four different countries through a metagenomic approach.Materials and MethodsSubgingival samples were obtained from subjects from four different countries. Microbial composition was analysed through high‐throughput sequencing of the V3–V4 region of the 16S rRNA gene. The country of origin, diagnosis and clinical and demographic variables of the subjects were used to analyse the microbial profiles.ResultsIn total, 506 subgingival samples were analysed: 196 from HS and 310 from patients with periodontitis. Differences in richness, diversity and microbial composition were observed when comparing samples pertaining to different countries of origin and different subject diagnoses. Clinical variables, such as bleeding on probing, did not significantly affect the bacterial composition of the samples. A highly conserved core of microbiota associated with periodontitis was detected, while the microbiota associated with periodontally HS was much more diverse.ConclusionsPeriodontal diagnosis of the subjects was the main variable explaining the composition of the microbiota in the subgingival niche. Nevertheless, the country of origin also had a significant impact on the microbiota and is therefore an important factor to consider when describing subgingival bacterial communities.

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Section: Discussionmentioning

confidence: 66%

Comparative 16S rRNA gene sequencing study of subgingival microbiota of healthy subjects and patients with periodontitis from four different countries

Arredondo

Álvarez

Isabal

et al. 2023

J Clinic Periodontology

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“…On the other hand, in most existing microbial-related studies, the analysis of microbiomes mainly depends on the 16S rRNA sequencing technique to understand the distribution, classification and diversity of GM in specific diseases [ [68] , [69] , [70] ]. However, the existing difficulty is that current 16S rRNA sequencing technique is still not able to distinguish whether the microbiomes are active or not, and there is still a lack of resolution beyond the genus level [ 71 , 72 ]. Nevertheless, with the evolution of sequencing techniques and the improvement of data processing, the above drawbacks may be effectively solved in the near future.…”

Section: Discussionmentioning

confidence: 99%

Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function

Zhang¹,

Cao²,

Li³

et al. 2022

Journal of Orthopaedic Translation

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“…The human gut microbiota, containing more than 500 species of bacteria, is an intricate dynamic ecological community comprising trillions of microorganisms (∼4 × 10 13 ) residing in the human intestinal wall and lumen in a direct biological symbiotic interaction (Hou et al, 2022). Some 90% of human gut microbial phyla are mainly Firmicutes and Bacteroidetes, and other minor groups (Actinobacteria, Proteobacteria, Fusobacteria, and Verrucomicrobia), information, that is, however biased toward western microbiomes, whereas the effective attributes of different members of these phyla remain obscure (Piquer-Esteban et al, 2022).…”

Section: The Gut Microbiotamentioning

confidence: 99%

“…Some 90% of human gut microbial phyla are mainly Firmicutes and Bacteroidetes , and other minor groups ( Actinobacteria , Proteobacteria , Fusobacteria , and Verrucomicrobia ), information, that is, however biased toward western microbiomes, whereas the effective attributes of different members of these phyla remain obscure (Piquer‐Esteban et al., 2022).…”

Section: The Gut Microbiotamentioning

confidence: 99%

The imprecision of micronutrient requirement values: the example of vitamin D

Fernandes,

Bell

2023

Journal of Food Science

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Food, not nutrients, is the fundamental unit in nutrition. Nutrient requirement values and recommended daily intakes have long been determined and organized in tables by several regulators. These figures, however, overlook the complexity of mixing different foods in a diet and the mediation by human gut microbiota on digestion, metabolism, and health. The microbiome molecular mechanisms and its potential influence on nutrient requirements are far from clear. Guidelines should depend on the sort of intake, along with the dietary habits, rather than focusing on single nutrients. Despite many decades of attempts to investigate the proximate nutrient composition of foods consumed by different world populations, there are still neither standardization of food composition databases nor harmonized dietary intake methods of assessment of nutrients. No all‐inclusive attempt was yet made to emphasize the requirements of the various micronutrients, phytonutrients, and non‐nutrients on gut microbiota and vice versa, and thereafter reflected into dietary guidelines. New multifaceted methods have been advanced to reevaluate the way nutrients and nutrient requirements are assessed within the intricate biological systems. Our main goal here was to enhance the fact that existing food guidelines hold inherent strengths and limitations but fail, in many aspects, namely, in not taking into account essential geographical, ethnic and cultural differences, and the different stages of life, infant nutrition, and the microbiota impact on several micronutrient requirements. Vitamin D is given as an illustration on present inaccuracy of its requirements. Defining dietary reference intakes is therefore an ongoing process specific for each population.

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Exploring the universal healthy human gut microbiota around the World

Abstract: Graphical abstract

Cited by 26 publications

References 117 publications

Comparative 16S rRNA gene sequencing study of subgingival microbiota of healthy subjects and patients with periodontitis from four different countries

Comparative 16S rRNA gene sequencing study of subgingival microbiota of healthy subjects and patients with periodontitis from four different countries

Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function

The imprecision of micronutrient requirement values: the example of vitamin D

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