Exploring the dysregulated mRNAs–miRNAs–lncRNAs interactions associated to idiopathic non-obstructive azoospermia

Sabetian, Soudabeh; Zarei, Mahboubeh; Jahromi, Bahia Namavar; Morowvat, Mohammad Hossein; Tabei, Seyed Mohammad Bagher; Cava, Claudia

doi:10.1080/07391102.2021.1875879

Cited by 6 publications

(8 citation statements)

References 38 publications

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“…One more article was also excluded, as it was a perspective and did not present original data. Finally, a total of 20 articles remained to be included in the present systematic review [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…Investigation of target genes involved in ceRNA networks led researchers to the conclusion that testicular lncRNAs regulate spermatogonial cell proliferation or spermatocyte meiosis. Similarly, Sabetian et al (2022) [ 33 ] found that differentially expressed lncRNAs, miRNAs, and mRNAs in patients with idiopathic NOA constructed mRNA-miRNA-lncRNA interaction networks. A total of 10 lncRNAs were identified to be downregulated in NOA patients in comparison with healthy individuals ( Table S2 ).…”

Section: Resultsmentioning

confidence: 99%

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The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis

Kyrgiafini

Sarafidou

Mamuris

2022

Biology

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Male infertility is a complex disorder affecting many couples worldwide. Long noncoding RNAs (lncRNAs) regulate important cellular processes; however, a comprehensive understanding of their role in male infertility is limited. This systematic review investigates the differential expressions of lncRNAs in male infertility or variations in lncRNA regions associated with it. The PRISMA guidelines were used to search Pubmed and Web of Science (1 June 2022). Inclusion criteria were human participants, patients diagnosed with male infertility, and English language speakers. We also performed an in silico analysis investigating lncRNAs that are reported in many subtypes of male infertility. A total of 625 articles were found, and after the screening and eligibility stages, 20 studies were included in the final sample. Many lncRNAs are deregulated in male infertility, and interactions between lncRNAs and miRNAs play an important role. However, there is a knowledge gap regarding the impact of variants found in lncRNA regions. Furthermore, eight lncRNAs were identified as differentially expressed in many subtypes of male infertility. After in silico analysis, gene ontology (GO) and KEGG enrichment analysis of the genes targeted by them revealed their association with bladder and prostate cancer. However, pathways involved in general in tumorigenesis and cancer development of all types, such as p53 pathways, apoptosis, and cell death, were also enriched, indicating a link between cancer and male infertility. This evidence, however, is preliminary. Future research is needed to explore the exact mechanism of action of the identified lncRNAs and investigate the association between male infertility and cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis

Kyrgiafini

Sarafidou

Mamuris

2022

Biology

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“…Among them, LINC00661, LINC00643, LINC00654, LINC00301, LINC00238, and LINC00905 were associated with miR-27-b-3p, and LINC00905, LINC00643, LINC00661, and LINC00654 were associated with miR-509-3-5p. MiR-509-5p and miR-27b-3p interact with target genes PLK1 and CRISP2, respectively ( 69 ).…”

Section: Lncrnamentioning

confidence: 99%

The gene regulatory role of non-coding RNAs in non-obstructive azoospermia

Zhou

Zhang

et al. 2022

Front. Endocrinol.

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Non-coding RNAs are classified as small non-coding RNAs, long non-coding RNAs and circular RNAs, which are involved in a variety of biological processes, including cell differentiation, proliferation, apoptosis and pathological conditions of various diseases. Many studies have shown that non-coding RNAs are related to spermatogenesis, maturation, apoptosis, function, etc. In addition, the expression of non-coding RNAs in testicular tissue and semen of patients with non-obstructive azoospermia was different. However, the role of non-coding RNAs in the pathogenesis of non-obstructive azoospermia has not been fully elucidated, and the role of non-coding RNAs in non-obstructive azoospermia is rarely reviewed. Here we summarize the research progress of non-coding RNAs in the pathogenesis of non-obstructive azoospermia.

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“…Abnormal expression of long noncoding RNAs ( lncRNAs ) and their corresponding pathogenic roles in nonobstructive azoospermia have been illuminated in recent years ( Zhou et al, 2019 ; Sabetian et al, 2021b ). miRNA-122-5p promotes human spermatogonia stem cell proliferation and DNA synthesis through regulating the Cbl gene and competitively binding to lncRNA-Casc7 ( Zhou et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of lncRNA-Gm2044 in spermatogonia impairs spermatogenesis in partial seminiferous tubules

Gao

et al. 2022

Poultry Science

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Exploring the dysregulated mRNAs–miRNAs–lncRNAs interactions associated to idiopathic non-obstructive azoospermia

Cited by 6 publications

References 38 publications

The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis

The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis

The gene regulatory role of non-coding RNAs in non-obstructive azoospermia

Overexpression of lncRNA-Gm2044 in spermatogonia impairs spermatogenesis in partial seminiferous tubules

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