Exploring solid forms of oxytetracycline hydrochloride

Bueno, Maria Soledad; Miñambres, Guadalupe Gloria; Bongioanni, Agustina; Chattah, Ana K.; Aiassa, Virginia; Longhi, Marcela Raquel

doi:10.1016/j.ijpharm.2020.119496

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…OxyCl solid forms were obtained as stated in our prior report [ 24 ]. OxyCl-II was produced by the slow evaporation of a saturated solution of commercial form (OxyCl-I) in isopropyl alcohol.…”

Section: Methodsmentioning

confidence: 99%

“…Oxytetracycline hydrochloride (OxyCl) ( Figure 1 ) is a polymorphic tetracycline antibiotic of the broad-spectrum that is frequently used for treating respiratory tract infections, urethritis, severe acne, and also in the treatment of multidrug resistant malaria. Recent studies evidence that OxyCl polymorphs exhibited similar antimicrobial activity [ 24 ]. OxyCl is known to undergo several chemical reactions.…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceutical Systems as a Strategy to Enhance the Stability of Oxytetracycline Hydrochloride Polymorphs in Solution

2023

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In order to improve the stability of oxytetracycline hydrochloride, a polymorphic antibiotic set of novel binary systems were developed using β-cyclodextrin and amino acids with different acid-basic characteristics as ligands. The formation constants for each system containing β-cyclodextrin, L-aspartic acid, histidine and N-acetylcysteine were determined by Scott’s method and statistical studies. The structure of the binary systems with β-cyclodextrin and N-acetylcysteine was elucidated by NMR experiments. The effect β-cyclodextrin and N-acetylcysteine on the polymorph’s chemical stability in aqueous and phosphate buffered saline solutions at 25 °C was monitored by an optimized and validated high-performance liquid chromatography method. The combination of N-acetylcysteine with the three polymorphs and the β-cyclodextrin system obtained with the form III demonstrated a reduction in the degradation rate of oxytetracycline hydrochloride in the aqueous solution when compared to each free form, with an increase of 20 h in the half time. It evidences that the use of amino acids as ligands constitutes an interesting alternative for pharmaceutical areas. In conclusion, based on the results obtained, these pharmaceutical systems could be candidates for the development of a pharmaceutical formulation for the administration of the drug through reconstituted solutions using the binary system as a promising tool for improving the stability of oxytetracycline hydrochloride polymorphs in solution.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Systems as a Strategy to Enhance the Stability of Oxytetracycline Hydrochloride Polymorphs in Solution

2023

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“…In general, different polymorphs show solubility differences typically smaller than 10 times due to relative differences in free energy. Some examples include the evaluation of solubility, in aqueous and buffer solutions, of several forms of furosemide [47], norfloxacin [48][49][50], albendazole [51], and oxytetracycline hydrochloride [52]. These studies demonstrate that the molecular arrangement of each polymorphic form and its degree of ionization has a considerable impact on drug solubility (Table 1).…”

Section: Solid Form Impact On Physicochemical and Biopharmaceutical P...mentioning

confidence: 99%

Pharmaceutical Crystals: Development, Optimization, Characterization and Biopharmaceutical Aspects

Bongioanni¹,

Bueno²,

Mezzano³

et al. 2023

Crystal Growth and Chirality - Technologies and Applications

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In the solid state, the active pharmaceutical ingredients tend to exhibit crystalline order. In this regard, the interest in the crystalline solid state has expanded to include single-component compounds as well as multicomponent systems such as salts, hydrates, solvates, and co-crystals. The study of crystalline behavior is recognized as an essential component of preformulation research in pharmaceutical sciences and industries. The crystalline form can impact the drug properties such as solubility, dissolution rate, stability, hygroscopicity, and toxicity profile. Therefore, each solid form must be appropriately identified and characterized because it will affect the drug formulation, including the pharmacokinetic, pharmacodynamic, and safety properties of the formulation. In this context, this chapter will cover topics such as synthesis approaches (including nucleation and crystallization procedures), crystal polymorphism, solid state characterization techniques and the impact of crystals on physicochemical and biopharmaceutical properties.

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“…Bu sonuç, partikül kümeleri veya aglomeralarından kaynaklanabilecek, düzgün olmayan boyut ve şekle sahip yarık şekilli gözeneklerin (plakalar veya kenarlı partiküller) bir özelliğini göstermektedir [8] bölgelerden elde edilen klinoptilolitlerin pik verdiği açılarla benzerlik ve yakınlık göstermektedir [8,45]. Daha önce yapılan çalışmalarda TC'lerin XRD analizinde 2ϴ: 10,55-30,95˚ açısal aralıklarda pikler gösterdiği belirtilmiştir [46,47]. Karakteristik olarak doğal zeolit ile OTC-HCL adsorpsiyonundan sonra 2Ɵ: 9,96°-22,36°-26,71°-28,08°-30,26°-32,10° derecelerinde elde edilen zirveler bunu doğrulamaktadır.…”

Section: N2 Adsorpsiyon-desorpsiyon Analizi (N2 Adsorption-desorption...unclassified

Oksitetrasiklin hidroklorürün doğal zeolit ile sulu çözeltilerden giderimi

Başkan

Açıkel

Levent

2023

Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi

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Antibiyotik kalıntılarının su kaynaklarındaki toksisitesi çevreyi olumsuz etkilemektedir. Son yıllarda yapılan çalışmalar antibiyotikler gibi organik kirleticilerin ucuz ve çevreye uyumlu adsorbentlerle sulu çözeltilerden giderimine odaklanmıştır. Bu çalışmada, doğal Manisa-Gördes klinoptiloliti oksitetrasiklin hidroklorür (OTC-HCL) adsorpsiyonu, kesikli sisteminde 298-323 K'de incelenmiştir. pH, başlangıç konsantrasyonu, adsorban dozu, temas süresi, karıştırma hızı ve sıcaklığın adsorpsiyon üzerindeki etkileri incelenmiş ve optimum parametreler belirlenmiştir. Adsorpsiyon izotermleri Langmuir, Freundlich, Dubinin-Radushkevich (D-R), Temkin modelleri kullanılarak analiz edilmiştir. Kinetik sabitler yalancı birinci derece, yalancı ikinci derece, inratapartikül difüzyon ve Elovich modelleriyle belirlenmiştir. Doğal zeolitin OTC-HCL adsorpsiyonu, en iyi Freundlich izotermine ve sözde ikinci dereceden kinetik modeline uymuştur. Doğal zeolitin maksimum adsorpsiyon kapasitesi 323 K'de 60,97 mg/g olarak belirlenmiştir. Termodinamik çalışmalar, OTC-HCL’nin doğal zeolit ile adsorpsiyonunun kendiliğinden ve endotermik olduğunu göstermiştir. Doğal zeolitin fizikokimyasal karakterizasyonu adsorpsiyondan önce ve sonra, N2 adsorpsiyon-desorpsiyon, XRD, FTIR, SEM-EDX analizleri ile gerçekleştirilmiştir. Doğal zeolitin BET spesfik yüzey alanı, adsorpsiyon sürecine bağlı olarak adsorpsiyon sonrasında azalmıştır. Karakterizasyon sonuçları, doğal zeolit yüzeyinde OTC-HCL moleküllerinin başarılı bir adsorbe olduğunu göstermiştir.

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Exploring solid forms of oxytetracycline hydrochloride

Cited by 9 publications

References 15 publications

Pharmaceutical Systems as a Strategy to Enhance the Stability of Oxytetracycline Hydrochloride Polymorphs in Solution

Pharmaceutical Systems as a Strategy to Enhance the Stability of Oxytetracycline Hydrochloride Polymorphs in Solution

Pharmaceutical Crystals: Development, Optimization, Characterization and Biopharmaceutical Aspects

Oksitetrasiklin hidroklorürün doğal zeolit ile sulu çözeltilerden giderimi

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