Exploring Azatidinone Moiety: An Insight into its Anti-tubercular Potency

Abstract

TB is becoming a worldwide problem and it was declared since 1993 by the World Health Organization (WHO), a global health emergency. The current problem of tuberculosis therapy is the emergence of multi-drug resistant (MDR) strains, caused by the improper use of antibiotics in chemotherapy of TB patients. Azatidinones, a β-lactam cyclic amide with four atoms in a ring, has been considered as a magic moiety (wonder nucleus) which possesses almost all types of biological activities. This diversity in the biological response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Present article is sincere attempt to review chemistry, method of synthesis of azatidinones and to study azatidinones synthesized in last few years which have shown potent antitubercular activity.

Selective Detection of Copper Ions and Biological Activities of Isoniazid Schiff Bases

“…CÀ H bending of aromatic at 846 cm À 1 , aromatic ring mono substitution at 748 cm À 1 , 680 cm À 1 , CÀ N stretch at 1042 cm À 1 , 1154 cm À 1 , 1292 cm À 1 . [17] 1 H and 13 C spectra of S2 were also reported in our previous work. [17] 1 H: The H 1 NMR spectral data of compound S2 are consistent with the literature.…”

“…The absence of both peaks for Cu 2 + + S1 complexation was validated for the deprotonation of the NÀ H protons and the involvement of the carbonyl and hydrazonyl group in complexation with the Cu 2 + ions. [40] 1 H and 13 C spectra of S1 were also reported in our previous work. [17] 1 H: The 1 H NMR spectral data of the ligand S1 agreed with the literature data.…”

Oxadiazole: A highly versatile scaffold in drug discovery

“…Das et al [101] prepared pyrazine containing 1,3,4-oxadiazoles clubbed with substituted azetidin-2-ones as potential antitubercular agents. 28).…”

Design, Synthesis, Antimicrobial Evaluation of Novel 2‐Oxo‐4‐Substituted Aryl‐Azetidine Benzotriazole Derivatives**

“…Moreover, azetidine-2-one structural moiety has almost recognized as therapeutic potential. [20] Benzotriazole and its Pharmacological Activity [21][22][23][24][25][26][27][28] Also act as strong vasodilator, hypotensive, antibacterial, antifungal, and antiparasitic properties were demonstrated by benzofuran derivatives. [29] Different nitrogen-containing spiroheterocyclic derivatives were isolated from natural sources and prepared synthetically such as from frog neurotoxin example histrionicotoxin 283 A, shelf fish toxins includes spirolides etc.…”

“…All these β‐lactam antibiotics have been significant fought against pathogenic microbial infection to treat several related diseases. Moreover, azetidine‐2‐one structural moiety has almost recognized as therapeutic potential [20] …”