Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes – a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste – for the longer-term relief of dentine hypersensitivity

Hall, Claire; Mason, Stephen; Cooke, Jonathan

doi:10.1016/j.jdent.2017.02.009

Cited by 30 publications

(30 citation statements)

References 20 publications

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“…The air-blast stimulus could better mimic the practical situation, since patients experienced sensitivity from cold water, food or air more frequently than other stimuli. In addition, many studies showed correlation between the results of air-blast test and tactile test [29,[34][35][36]. It is recommended that at least two independent stimuli should be applied [37], so secondary outcomes such as tactile, cold water test or subjective questionnaire could provide more supporting evidence in assessing DH degree.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a randomized controlled trial

Ding

Dai

et al. 2020

BMC Oral Health

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Background: Dentine hypersensitivity (DH) could occur or intensify after non-surgical periodontal therapy because of the exposure of dentine tubules, but currently no gold standard exists to treat DH. It has been demonstrated that nano-sized particles presented potential for dentine tubules blocking and remineralization. This randomized controlled trial aimed to investigate the efficacy of dentifrice containing nano-carbonate apatite (n-CAP) in reducing dentine hypersensitivity (DH) after non-surgical periodontal therapy. Methods: 48 periodontitis patients with DH were included in this clinical trial. After non-surgical periodontal therapy, patients included were randomized to test and control group and the respective dentifrices were applied at chairside, after which they were instructed to brush teeth with the allocated dentifrices twice a day at home. Periodontal parameters were recorded at baseline and the last follow-up. DH was measured by air-blast test and recorded by visual analogue scale (VAS) and Schiff sensitivity scale at baseline, after polishing (0 week) and 2/4/6 weeks. Results: 45 participants completed the follow-up. Periodontal parameters were improved and comparable between groups. Significant reduction in DH was observed in both groups at all time-points compared to baseline in terms of VAS and Schiff score. The test group achieved significantly greater relief from hypersensitivity compared with the control group after 4-week at-home use (for change of VAS, test group: 2.27 ± 2.47 versus control group: 1.68 ± 2.24, p = 0.036; for change of Schiff, test group: 0.94 ± 0.92 versus control group: 0.61 ± 0.83, p < 0.001). The 6-week results showed borderline significance between groups in terms of change of Schiff (p = 0.027) and no significance in terms of change of VAS (p = 0.256).

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Section: Discussionmentioning

confidence: 99%

Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a randomized controlled trial

Ding

Dai

et al. 2020

BMC Oral Health

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“…Sensitivity to mechanical, chemical and thermal stimuli was assessed using the 4-point index for each tooth, scored as: 0 = subject does not respond to temperature, chemical, mechanical stimulus; 1 = subject responds to temperature stimulus; 2 = subject responds to temperature stimulus and chemical stimulus; 3 = subject responds to temperature stimulus, chemical stimulus and mechanical stimulus [8,9].…”

Section: Safetymentioning

confidence: 99%

Untitled

2019

Int J Oral Dent Health

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tive, tactile, osmotic or chemical, and that cannot be ascribed to any other form of dental defect or pathology" [1]. Dentine hypersensitivity is a significant burden for patients and practitioners. Knowing its prevalence and methods for accurate diagnosis is imperative to guide treatment decisions and develop new treatments. A wide range of estimates of prevalence of dentine hypersensitivity was observed in 56 studies, from as low as 1.8% to as high as 84%, and this heterogeneity could not be completely explained by study characteristics. The meta-analysis revealed that the average prevalence of all studies was 33% and the best estimate was approximately 10% [2,3]. One of the most frequent patient complaints is related to cold stimuli, although pain may also occur when consuming acidic foods (mainly fruit), sweets and salty foods. Tactile stimulus provocation frequently occurs when patients brush their teeth or rub the sensitive area with a finger nail [4]. DH may disturb patients during eating, drinking and brushing. The prevalence of DH has been reported to be in the range of 8 to 57. Hypersensitivity may occur wherever the dentin is exposed by attrition or abrasion, or the root surface is exposed by periodontal disease. In regard to the pain pathogenic mechanism, several theories have been proposed. Nowadays, the most accepted one is Brannstrom's hydrodynamic theory [5]. According to this theory, DH is caused by shifts in the fluid located inside the open dentin tubules. This

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“…Among these agents, bioglasses offer unique properties and proven clinical efficacy. Recently introduced calcium sodium phosphosilicate (Novamin), is a particulate bioactive glass 3 which preferentially binds to exposed tubules 4 ; on exposure to the aqueous oral environment, it provides calcium and phosphate ions to form a hydroxycarbonate apatite-like layer on the dentine surface and within the tubules resulting in tubular occlusion. 5 A novel modification of Novamin, fluoro-calcium phosphosilicate, or Biomin was introduced in 2016.…”

Section: Introductionmentioning

confidence: 99%

Clinical Comparison of 5% Fluoro Calcium Phosphosilicate Versus 5% Calcium Sodium Phosphosilicate in the Treatment of Dentinal Hypersensitivity

Hussain

Jan

Behal

2019

IJMBS

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Dentinal hypersensitivity is a perplexing problem for the patient as well as clinician. Among the plethora of pharmacological agents developed for the management of this rather common affliction, tubule occluding agents form the mainstay of treatment. Bioglasses (phosphosilicates) with evolving chemical and biological properties, are widely used, with the latest modification being the addition of fluoride to conventional calcium sodium phosphosilicate (Novamin) to result in fluoro calcium phosphosilicate (Biomin), purported to have superior tubule occlusive properties. The present study was designed as randomized clinical trial to compare the efficacy of Biomin and Novamin in reducing the subjective and provoked (thermal) experience of dentinal hypersensitivity. Sixty subjects were randomly prescribed three dentifrices after oral prophylaxis: Group A (20 patients): dentifrice containing 5% fluoro calcium phosphosilicate (Biomin); Group B (20 patients): dentifrice containing 5% calcium sodium phosphosilicate (Novamin); Group C (20 patients): standard dentifrice containing fluoride. Subjective and thermal sensitivity was assessed using a 10 point VAS score at baseline, at 15 days, 30 days and 60 days of treatment. It was found that though significant reduction in hypersensitivity was observed for all three groups over time, flouro calcium phosphosilicate was most effective in reducing the VAS score, followed by calcium sodium phosphosilicate and fluoride. It was concluded that fluoro calcium phosphosilicate is a promising agent for clinical management of dentinal hypersensitivity.

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Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes – a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste – for the longer-term relief of dentine hypersensitivity

Cited by 30 publications

References 20 publications

Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a randomized controlled trial

Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a randomized controlled trial

Untitled

Clinical Comparison of 5% Fluoro Calcium Phosphosilicate Versus 5% Calcium Sodium Phosphosilicate in the Treatment of Dentinal Hypersensitivity

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