Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review

Riccio, Bruno Vincenzo Fiod; Silvestre, Amanda Letícia Polli; Meneguin, Andréía Bagliotti; Ribeiro, Taís de Cássia; Klosowski, Ana Beatriz; Ferrari, Priscileila Colerato; Chorilli, Marlus

doi:10.1208/s12249-022-02414-6

Cited by 16 publications

(11 citation statements)

References 182 publications

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“…67 Further, a biopolymers films for drug delivery and tissue engineering were prepared through the template synthesis or by 3D printing technology which is very costly. 68 Silk-based polymer films also reported that loaded with DOX, however, cell inhibition found to be maximum 27%, which is quite low with respect to the present work. 69 However, with respect to all the reported works on polymer film loaded with DOX, the novel porous polymer [(pNIPAM)-b-(PCL)] film synthesized in this work is new, the fabrication of porous polymer films of [(pNIPAM)-b-(PCL)] is free from any soft or solid template synthesis approach, and novel work explored the use of the PPTF in the loading of DOX and used for the skin cancer cells with very high efficiency and low doses of DOX release.…”

Section: Discussioncontrasting

confidence: 79%

“…DOX loaded in chitosan hydrogel film reported, however the release was studied in acetic acid and within 1 h release reached to 70%, which was very first release 67 . Further, a biopolymers films for drug delivery and tissue engineering were prepared through the template synthesis or by 3D printing technology which is very costly 68 . Silk‐based polymer films also reported that loaded with DOX, however, cell inhibition found to be maximum 27%, which is quite low with respect to the present work 69 .…”

Section: Discussionmentioning

confidence: 99%

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Controlled synthesis of thermosensitive tunable porous film of (pNIPAM)‐b‐(PCL) copolymer for sustain drug delivery

Amgoth

Patra

Wasnik

et al. 2023

J of Applied Polymer Sci

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There have been reports on different types of porous polymer films for various applications. The designing of such porous films with uniform properties is a challenging task. In this work, tunable porous thin films of poly(N‐isopropylacrylamide) (pNIPAM) and polycaprolactone (PCL), that is, (pNIPAM)‐b‐(PCL) has been fabricated and its sustained drug delivery applications have been reported. First, the (pNIPAM)‐b‐(PCL) has been synthesized through the addition polymerization of pNIPAM and PCL. Then the synthesized (pNIPAM)‐b‐(PCL) has been used to design porous thin film with varying temperatures without using any external template, below and above the lower critical solution temperatures (LCST) of pNIPAM. Pore size in (pNIPAM)‐b‐(PCL) films has been tuned by varying the temperature from ~10 to 40°C. Then the developed thermosensitive porous film has been taken and seeded with the K562 (chronic myeloid leukemia blood cancer) and HepG2 (hepatocarcinoma) cells and the skin cancer cells (B16‐F10) killing efficiency of anticancer drug (e.g., doxorubicin hydrochloride, DOX) loaded (pNIPAM)‐b‐(PCL) film has been studied. It is found that the DOX‐loaded (pNIPAM)‐b‐(PCL) can efficiently kill the skin cancer cells. The porous polymer thin film reported in this work can be a versatile platform for the loading of drugs and it can be used for the various therapeutic applications.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Controlled synthesis of thermosensitive tunable porous film of (pNIPAM)‐b‐(PCL) copolymer for sustain drug delivery

Amgoth

Patra

Wasnik

et al. 2023

J of Applied Polymer Sci

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“…By 3D printing, it is possible to create polymer films with different porosity, mechanical properties and drug loading to meet the needs of topical drug delivery in different situations. The need for materials with low viscosity, droplet size, lack of precision in positioning, high cost and long production time are factors that limit the widespread use of 3D printing technology for polymer films ( Riccio et al, 2022 ).…”

Section: Drug Delivery Systems and Factors Affecting Transdermal Drug...mentioning

confidence: 99%

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

Zhao,

Chen,

Bai

et al. 2024

Front. Pharmacol.

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Topical drug delivery is widely used in various diseases because of the advantages of not passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first-pass effect, and reaching the lesion directly to reduce unnecessary adverse reactions. The skin helps the organism to defend itself against a huge majority of external aggressions and is one of the most important lines of defense of the body. However, the skin’s strong barrier ability is also a huge obstacle to the effectiveness of topical medications. Allowing the bioactive, composition in a drug to pass through the stratum corneum barrier as needed to reach the target site is the most essential need for the bioactive, composition to exert its therapeutic effect. The state of the skin barrier, the choice of delivery system for the bioactive, composition, and individualized disease detection and dosing planning influence the effectiveness of topical medications. Nowadays, enhancing transdermal absorption of topically applied drugs is the hottest research area. However, enhancing transdermal absorption of drugs is not the first choice to improve the effectiveness of all drugs. Excessive transdermal absorption enhances topical drug accumulation at non-target sites and the occurrence of adverse reactions. This paper introduces topical drug delivery strategies to improve drug effectiveness from three perspectives: skin barrier, drug delivery system and individualized drug delivery, describes the current status and shortcomings of topical drug research, and provides new directions and ideas for topical drug research.

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“…These thin, flexible sheets composed of biocompatible polymers offer a versatile platform for controlled drug release, allowing for precise dosing and prolonged therapeutic effects. [ 71 ] Their ease of application and potential for localized treatments make them an attractive option for various medical scenarios. Notably, the integration of CPs into these polymeric films has introduced an exciting dimension to drug delivery.…”

Section: Cps In Drug Deliverymentioning

confidence: 99%

“…Notably, the integration of CPs into these polymeric films has introduced an exciting dimension to drug delivery. [ 71a ] By leveraging the electrical properties of CPs, these films can respond to electric fields, enabling triggered drug release. [ 19 ]…”

Section: Cps In Drug Deliverymentioning

confidence: 99%

Electroactive Polymers for On‐Demand Drug Release

Alkahtani,

Elbadawi,

Chapman

et al. 2023

Adv Healthcare Materials

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Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of our daily lives. Conductive polymers (CPs) are an emerging group of polymers that possess metal‐like conductivity yet retain desirable polymeric features, such as processability, mechanical properties and biodegradability. Upon receiving an electrical stimulus, CPs can be tailored to achieve a number of responses, such as harvesting energy, biosensing and stimulating tissue growth. The recent FDA approval of a CP‐based material for a medical device has invigorated their research in healthcare, including as biosensors, tissue engineering grafts and implants. In drug delivery, CPs can act as electrical switches, drug release is achieved at a flick of a switch, thereby providing unprecedented control over drug release. In this review, recent developments in CP as electro‐active polymers for voltage‐stimuli responsive drug delivery systems are evaluated. The review demonstrates the distinct drug release profiles achieved by electro‐active formulations, and both the precision and ease of stimuli response. This level of dynamism promises to yield “smart medicines” and warrants further research. The review concludes by providing an outlook to electro‐active formulations in drug delivery and highlighting their integral roles in healthcare IoT.This article is protected by copyright. All rights reserved

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Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review

Cited by 16 publications

References 182 publications

Controlled synthesis of thermosensitive tunable porous film of (pNIPAM)‐b‐(PCL) copolymer for sustain drug delivery

Controlled synthesis of thermosensitive tunable porous film of (pNIPAM)‐b‐(PCL) copolymer for sustain drug delivery

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

Electroactive Polymers for On‐Demand Drug Release

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