Controlled synthesis of thermosensitive tunable porous film of (<scp>pNIPAM</scp>)‐<i>b</i>‐(<scp>PCL</scp>) copolymer for sustain drug delivery

Amgoth, Chander; Patra, Sukanya; Wasnik, Kirti; Maity, Pradip; Paik, Pradip

doi:10.1002/app.53854

Cited by 1 publication

(1 citation statement)

References 70 publications

(123 reference statements)

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“…As shown in Figure 9, the p(NIPAm-co-Am) NG/Cur sample was more toxic to MDA-MB-231 cells than pure Cur at equivalent dosages. This might be because the gradual release of Cur from the p(NIPAm-co-Am) NG/Cur sample induced more cell toxicity than pure Cur alone [40,41]. Because of the MTT assay results, the synthesized p(NIPAm-co-Am) NG system is biocompatible and might be used for pH and temperature-responsive drug delivery applications.…”

Section: Stimuli-responsive Drug Delivery Behavior Of the P(nipam-co-...mentioning

confidence: 99%

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

Moorthy

Kim

2023

Gels

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Curcumin (Cur) is a beneficial ingredient with numerous bioactivities. However, due to its low solubility and poor bioavailability, its therapeutic application is limited. In this work, we prepared poly-N-isopropylacrylamide p(NIPAm) and polyallylamine p(Am)-based nanogel (p(NIPAm-co-Am)) NG for a dual pH- and temperature-sensitive copolymer system for drug delivery application. In this copolymer system, the p(NIPAm) segment was incorporated to introduce thermoresponsive behavior and the p(Am) segment was incorporated to introduce drug binding sites (amine groups) in the resulting (p(NIPAm-co-Am)) NG system. Various instrumental characterizations including 1H nuclear magnetic resonance (1H NMR) spectroscopy, Fourier transform infrared (FT-IR) analysis, scanning electron microscopy (SEM), zeta potential, and particle size analysis were performed to confirm the copolymer synthesis. Curcumin (Cur), an anticancer bioactive substance, was employed to assess the in vitro drug loading and release performance of the resulting copolymer nanogels system at varied pH levels (pH 7.2, 6.5, and 4.0) and temperatures (25 °C, 37 °C, and 42 °C). The cytocompatibility of the p(NIPAm-co-Am) NG sample was also tested on MDA-MB-231 cells at various sample concentrations. All the study results indicate that the p(NIPAm-co-Am) NG produced might be effective for drug loading and release under pH and temperature dual-stimuli conditions. As a result, the p(NIPAm-co-Am) NG system has the potential to be beneficial in the use of drug delivery applications in cancer therapy.

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Section: Stimuli-responsive Drug Delivery Behavior Of the P(nipam-co-...mentioning

confidence: 99%

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

Moorthy

Kim

2023

Gels

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Controlled synthesis of thermosensitive tunable porous film of (pNIPAM)‐b‐(PCL) copolymer for sustain drug delivery

Cited by 1 publication

References 70 publications

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

Dual pH- and Thermo-Sensitive Poly(N-isopropylacrylamide-co-allylamine) Nanogels for Curcumin Delivery: Swelling–Deswelling Behavior and Phase Transition Mechanism

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