Electroactive Polymers for On‐Demand Drug Release

Alkahtani, Manal E.; Elbadawi, Moe; Chapman, Christopher A. R.; Green, Rylie A.; Gaisford, Simon; Orlu, Mine; Basit, Abdul W.

doi:10.1002/adhm.202301759

Cited by 5 publications

(1 citation statement)

References 173 publications

(139 reference statements)

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“…Despite its infancy, SLS has been demonstrated to be a versatile technology capable of fabricating a range of drug delivery systems, including tablets with braille patterns, intrauterine devices, drug-loaded synthetic bone grafts, modular devices, and complex 3D gyroid geometries . SLS has also been used to print conductive material, microfluidic valves, and shape memory polymers, all of which are relevant to drug delivery. Beyond pharmaceutics, SLS has been adopted in industrial sectors, such as the aerospace and automotive industries .…”

Section: Introductionmentioning

confidence: 99%

Cold Laser Sintering of Medicines: Toward Carbon Neutral Pharmaceutical Printing

Elbadawi,

Li,

Ghosh

et al. 2024

ACS Sustainable Chem. Eng.

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Selective laser sintering (SLS) is an emerging threedimensional (3D) printing technology that uses a laser to fuse powder particles together, which allows the fabrication of personalized solid dosage forms. It possesses great potential for commercial use. However, a major drawback of SLS is the need to heat the powder bed while printing; this leads to high energy consumption (and hence a large carbon footprint), which may hinder its translation to industry. In this study, the concept of cold laser sintering (CLS) is introduced. In CLS, the aim is to sinter particles without heating the powder bed, where the energy from the laser, alone, is sufficient to fuse adjacent particles. The study demonstrated that a laser power above 1.8 W was sufficient to sinter both KollicoatIR and Eudragit L100-55-based formulations at room temperature. The cold sintering printing process was found to reduce carbon emissions by 99% compared to a commercial SLS printer. The CLS printed formulations possessed characteristics comparable to those made with conventional SLS printing, including a porous microstructure, fast disintegration time, and molecular dispersion of the drug. It was also possible to achieve higher drug loadings than was possible with conventional SLS printing. Increasing the laser power from 1.8 to 3.0 W increased the flexural strength of the printed formulations from 0.6 to 1.6 MPa, concomitantly increasing the disintegration time from 5 to over 300 s. CLS appears to offer a new route to laser-sintered pharmaceuticals that minimizes impact on the environment and is fit for purpose in Industry 5.0.

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Section: Introductionmentioning

confidence: 99%

Cold Laser Sintering of Medicines: Toward Carbon Neutral Pharmaceutical Printing

Elbadawi,

Li,

Ghosh

et al. 2024

ACS Sustainable Chem. Eng.

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Electrically Conductive Lignin Reinforced Polyacrylic Acid/Hyaluronic Acid Scaffolds With PEDOT:HA Nanoparticles

Winters,

Carsi,

Sanchis

et al. 2024

Polymers for Advanced Techs

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Hydrogel materials are continually developing in biomedical engineering and recently a lot of effort has gone into their engineered performance in physiological applications. Porosity is an important characteristic for tissue engineering scaffolds to allow enhanced biocompatibility and the pore size needed is dependent on the application and type of tissue for which the hydrogel is being used to regenerate. Regarding biomedical applications, the use of conducting polymers is gaining in popularity due to their promising biocompatibility and potential to stimulate cell growth and proliferation through electrical stimulation. Building on previous hydrogel development by the authors, this study focuses on developing a biocompatible hydrogel scaffold with adjustable porosity and swelling capabilities, robust mechanical properties, electrical conductivity, and high thermal stability. The objective of this work is to examine the effect of freezing temperature, cross‐linker and porosity on the final characteristics of the scaffold and to then determine possible applications. The porosity, swelling degree, compression strength, biocompatibility, electrical conductivity, and thermal characteristics of the final material were analyzed and were found to be affected by the varied synthesis methods used. Overall, the synthesized scaffolds exhibit good biocompatibility with increased fluorescence over 3 days and over 70% cell viability, thermal stability up to 200°C and a range of swelling of 1725% to 8472%. They also portray robust mechanical properties with a Young's Moduli range of 11 kPa to 4.54 MPa and a porosity range of 0.78–71.98 μm depending on the synthesis methods used. Through variations in synthesis methods, highly porous, absorbent, and stable scaffolds have been synthesized. Notably, this single recipe is highly tailorable for use in a range of biomedical applications from tissue engineering to drug delivery and wound repair.

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Electroactive self-standing polyester membranes prepared using magnetite/poly(3,4-ethylenedioxythiophene) core-shell particles

Molina,

Enshai,

Gil

et al. 2024

Polymer

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Electroactive Polymers for On‐Demand Drug Release

Cited by 5 publications

References 173 publications

Cold Laser Sintering of Medicines: Toward Carbon Neutral Pharmaceutical Printing

Cold Laser Sintering of Medicines: Toward Carbon Neutral Pharmaceutical Printing

Electrically Conductive Lignin Reinforced Polyacrylic Acid/Hyaluronic Acid Scaffolds With PEDOT:HA Nanoparticles

Electroactive self-standing polyester membranes prepared using magnetite/poly(3,4-ethylenedioxythiophene) core-shell particles

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