2018
DOI: 10.18632/aging.101384
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Abstract: Tri-phenyl-phosphonium (TPP) is a non-toxic chemical moiety that functionally behaves as a mitochondrial targeting signal (MTS) in living cells. Here, we explored the hypothesis that TPP-related compounds could be utilized to inhibit mitochondria in cancer stem cells (CSCs). We randomly selected 9 TPP-related compounds for screening, using an ATP depletion assay. Based on this approach, five compounds were identified as “positive hits”; two had no detectable effect on ATP production. Remarkably, this represent… Show more

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Cited by 31 publications
(36 citation statements)
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“…These mitochondria‐targeted mtK v 1.3 inhibitors, therefore, can be considered especially promising molecules for the treatment of several types of cancer, provided the tumour cells express high levels of mtK v 1.3. A recent study identified some TPP‐related compounds that might even eradicate cancer stem cells (Ozsvari et al ., ).…”
Section: Successfully Applied Strategies For In Vivo Subcellular Targmentioning
confidence: 97%
“…These mitochondria‐targeted mtK v 1.3 inhibitors, therefore, can be considered especially promising molecules for the treatment of several types of cancer, provided the tumour cells express high levels of mtK v 1.3. A recent study identified some TPP‐related compounds that might even eradicate cancer stem cells (Ozsvari et al ., ).…”
Section: Successfully Applied Strategies For In Vivo Subcellular Targmentioning
confidence: 97%
“…Because of the success of our drug repurposing efforts, we also decided to develop a series of new therapeutics, by focusing on key mitochondrial targets [2326]. These results are briefly summarized in Table 3.…”
Section: Mitochondrial-based Therapeutic Strategies For Eradicating Cmentioning
confidence: 99%
“…The use of tri-phenyl-phosphonium (TPP) also appears to be a very promising approach, as it behaves as a chemical mitochondrial targeting signal (MTS) (Figure 7, Lower) [26]. Interestingly, a series of TPP compounds we tested were non-toxic in normal fibroblasts, but were selectively toxic in “bulk” cancer cells and CSCs [26].…”
Section: Mitochondrial-based Therapeutic Strategies For Eradicating Cmentioning
confidence: 99%
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“…In this study, we cited a new copper complex, [Cu(ttpy‐tpp)Br 2 ]Br (expressed as CTB, shown in Figure A), which is obtained by introducing tri‐phenyl‐phosphine (TPP) into copper‐terpyridine complex. TPP is a non‐toxic chemical group that exhibits mitochondrial targeting properties in living cells . TPP can impart delocalized charge and lipophilic properties to the compound, which facilitates mitochondrial accumulation .…”
Section: Introductionmentioning
confidence: 99%