2019
DOI: 10.1111/bph.14544
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Abstract: The field of mitochondrial ion channels has undergone a rapid development during the last three decades, due to the molecular identification of some of the channels residing in the outer and inner membranes. Relevant information about the function of these channels in physiological and pathological settings was gained thanks to genetic models for a few, mitochondria‐specific channels. However, many ion channels have multiple localizations within the cell, hampering a clear‐cut determination of their function b… Show more

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Cited by 38 publications
(37 citation statements)
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References 403 publications
(392 reference statements)
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“…Mitochondrial potassium channels are regulated by similar factors (as plasma membrane potassium channels) such as ATP, Ca 2+ , ROS, heme, gasotransmitters, or free fatty acids. Additionally, such parameters as membrane potential and/or pH regulate in principle potassium channels in the same way in both the plasma membrane and the mitochondrial inner membrane [15,16,19,[63][64][65].…”
Section: Unique Regulation Of Mitochondrial Potassium Channels: Destimentioning
confidence: 99%
See 1 more Smart Citation
“…Mitochondrial potassium channels are regulated by similar factors (as plasma membrane potassium channels) such as ATP, Ca 2+ , ROS, heme, gasotransmitters, or free fatty acids. Additionally, such parameters as membrane potential and/or pH regulate in principle potassium channels in the same way in both the plasma membrane and the mitochondrial inner membrane [15,16,19,[63][64][65].…”
Section: Unique Regulation Of Mitochondrial Potassium Channels: Destimentioning
confidence: 99%
“…Second, potassium channels in the mitochondrial membrane are similar, due not only to biophysical properties but also pharmacological ones of potassium channels present in the plasma membrane. For example, mitochondrial ATP-regulated potassium (mitoK ATP ) channels were sensitive not only to ATP but also to antidiabetic sulfonylureas, such as glibenclamide and 5-hydroxydecanoic acid (5-HD), and to potassium channel openers, such as diazoxide [1,[18][19][20]. Recently, the molecular identities of mitochondrial (mitoBK Ca ) and plasma membrane large conductance Ca 2+ -activated potassium (BK Ca ) channels were determined to have a common genetic origin [21].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, several different types of anion and cation channels are known to be expressed in mitochondria. These include the voltage‐dependent anion channel (VDAC), KCa1.1, KCa3.1, KCa2.x, Kv1.3, Kv1.5, Kv7.4, Kir1.1b, K ATP , and K2P9.1 (TASK‐3) (Leanza et al, ). Interestingly, DCPIB has been shown to inhibit TASK‐3 and K ATP channels.…”
Section: Discussionmentioning
confidence: 99%
“…In earlier days, it was postulated that the mitochondrial membrane possesses a low-permeability of ions in order to maintain the electrochemical driving force; thus, ruling out the possibility of ion channels, transporters and exchangers in mitochondrial membranes (O'Rourke, 2007). Nevertheless, over the years, there have been identification of channels and ionic conductances in mitochondria (O'Rourke, 2007;Szabo and Zoratti, 2014;Leanza et al, 2018). Some of these channels and transporters are active under physiological conditions, whereas others get activated due to pathophysiological conditions to determine the fate of the cell (O'Rourke, 2007).…”
Section: Mitochondrial Ion Channels and Inflammatory Responsementioning
confidence: 99%