“…Classical descriptive morphologic studies have long suggested that the migration and rotation of the outflow tract is a critical factor in great vessel development (Bremer 1928;Congdon and Wang 1926) and errors in outflow tract location and orientation are frequently associated with congenital heart disease.…”
Section: Abnormal Orientation Of the Outflow Tract May Lead To Defectmentioning
confidence: 99%
“…In his experiments on chick embryos, Bremer speculated that the "descent" of the heart into the thorax results in significant torsion of the outflow tract, which is translated to the aortic arches, causing obliteration of some arches due to mechanical force (Bremer 1928 While substantial progress has been made in defining critical genes and proteins associated with normal outflow tract and aortic arch morphogenesis, the molecular mechanisms that determine changes in cell proliferation, differentiation, and matrix remodeling involved in asymmetric arch selection and…”
Section: Abnormal Orientation Of the Outflow Tract May Lead To Defectmentioning
confidence: 99%
“…For example, in the embryo, the aortic arches emerge as paired structures surrounding the foregut, with large arch curvatures, which are not captured in our planar model. Additionally, while we have examined the effects of the craniocaudal shift of the outflow tract, the lateral movement and axial rotation cannot be investigated in 2D and may play a similar role in shaping the aortic arches (Bremer 1928). Extending our optimization framework to 3D would improve the predictive capabilities and allow further investigation into arch development.…”
Section: D Geometry Vs 3d Aortic Arch Manifoldmentioning
confidence: 99%
“…The orientation and position of the outflow tract continues to shift as the spiral aortopulmonary septum septates the common trunk into the mature pulmonary artery and aorta (de la Cruz et al 1977;Dor and Corone 1985;Thompson et al 1987). Arresting the migration and rotation of the outflow tract by mechanical (Bremer 1928;Dor and Corone 1985;Gessner 1966) and genetic (Bajolle et al 2006;Liu et al 2002;Yashiro et al 2007) interventions have been shown to produce outflow tract and a variety of aortic arch abnormalities and has been implicated as a possible cause for several congenital defects in humans Goor and Edwards 1973;Lomonico et al 1988). …”
In the early embryo, a series of symmetric, paired vessels, the aortic arches, surround the foregut and distribute cardiac output to the growing embryo and fetus. During embryonic development the arch vessels undergo large-scale asymmetric morphogenesis to form species-specific adult great vessel patterns. These transformations occur within a dynamic biomechanical environment, which can play an important role in the development of normal arch configurations or the aberrant arch morphologies associated with congenital cardiac defects. Arrested migration and rotation of the embryonic outflow tract during late stages of cardiac looping has been shown to produce both outflow tract and several arch abnormalities. Here we investigate how changes in flow distribution
“…Classical descriptive morphologic studies have long suggested that the migration and rotation of the outflow tract is a critical factor in great vessel development (Bremer 1928;Congdon and Wang 1926) and errors in outflow tract location and orientation are frequently associated with congenital heart disease.…”
Section: Abnormal Orientation Of the Outflow Tract May Lead To Defectmentioning
confidence: 99%
“…In his experiments on chick embryos, Bremer speculated that the "descent" of the heart into the thorax results in significant torsion of the outflow tract, which is translated to the aortic arches, causing obliteration of some arches due to mechanical force (Bremer 1928 While substantial progress has been made in defining critical genes and proteins associated with normal outflow tract and aortic arch morphogenesis, the molecular mechanisms that determine changes in cell proliferation, differentiation, and matrix remodeling involved in asymmetric arch selection and…”
Section: Abnormal Orientation Of the Outflow Tract May Lead To Defectmentioning
confidence: 99%
“…For example, in the embryo, the aortic arches emerge as paired structures surrounding the foregut, with large arch curvatures, which are not captured in our planar model. Additionally, while we have examined the effects of the craniocaudal shift of the outflow tract, the lateral movement and axial rotation cannot be investigated in 2D and may play a similar role in shaping the aortic arches (Bremer 1928). Extending our optimization framework to 3D would improve the predictive capabilities and allow further investigation into arch development.…”
Section: D Geometry Vs 3d Aortic Arch Manifoldmentioning
confidence: 99%
“…The orientation and position of the outflow tract continues to shift as the spiral aortopulmonary septum septates the common trunk into the mature pulmonary artery and aorta (de la Cruz et al 1977;Dor and Corone 1985;Thompson et al 1987). Arresting the migration and rotation of the outflow tract by mechanical (Bremer 1928;Dor and Corone 1985;Gessner 1966) and genetic (Bajolle et al 2006;Liu et al 2002;Yashiro et al 2007) interventions have been shown to produce outflow tract and a variety of aortic arch abnormalities and has been implicated as a possible cause for several congenital defects in humans Goor and Edwards 1973;Lomonico et al 1988). …”
In the early embryo, a series of symmetric, paired vessels, the aortic arches, surround the foregut and distribute cardiac output to the growing embryo and fetus. During embryonic development the arch vessels undergo large-scale asymmetric morphogenesis to form species-specific adult great vessel patterns. These transformations occur within a dynamic biomechanical environment, which can play an important role in the development of normal arch configurations or the aberrant arch morphologies associated with congenital cardiac defects. Arrested migration and rotation of the embryonic outflow tract during late stages of cardiac looping has been shown to produce both outflow tract and several arch abnormalities. Here we investigate how changes in flow distribution
ntroductionMy interest in the aortic arch system in birds was stimulated by the discovery of a functional left radix aortae in the belted kingfisher during a routine dissection of that bird in 1938. Subsequent studies on several other species of birds produced interesting anatomical information, and, with continued studies, a semblance of order in occurrence of carotid patterns became more and more evident.After a reasonably large series of families and orders of birds had been examined, it appeared that further studies might produce information which could be of value in avian taxonomy. As a result, a series of systematic studies of the main arteries of the neck and thorax of birds was initiated and carried out over a period of about 12 years.During the past 2 or 3 years important implications with respect to the evolution of the aortic arch system in the bhds became more apparent, and the present treatise deals primarily with this aspect of my accumulated studies.
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