Experimentally induced stress, oxidative load and changes in immunity in a tropical wild bird, Perdicula asiatica: involvement of melatonin and glucocorticoid receptors

Yadav, Sanjeev Kumar; Haldar, Chandana

doi:10.1016/j.zool.2014.01.003

Cited by 13 publications

(7 citation statements)

References 45 publications

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“…Disrupted MLT levels in the first 48 h after traumatic stress exposure were shown to be associated with a higher PTSD development risk [233]. This is particularly interesting as several animal models have shown that melatonin can effectively counteract OXS and neurodegeneration, suppress various apoptotic markers, and ameliorate the oxidant effects of GCs induced by stressful conditions [234][235][236][237]. MLT has been especially shown to protect hippocampal neurons from oxidative stress, by preventing GC-related toxicity through a decrease of receptor translocation to nuclei in models of both sleep deprivation and chronic stress [236,[238][239][240].…”

Section: Circadian Dysregulation and Melatoninmentioning

confidence: 98%

Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review

2021

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Traumatic stress may chronically affect master homeostatic systems at the crossroads of peripheral and central susceptibility pathways and lead to the biological embedment of trauma-related allostatic trajectories through neurobiological alterations even decades later. Lately, there has been an exponential knowledge growth concerning the effect of traumatic stress on oxidative components and redox-state homeostasis. This extensive review encompasses a detailed description of the oxidative cascade components along with their physiological and pathophysiological functions and a systematic presentation of both preclinical and clinical, genetic and epigenetic human findings on trauma-related oxidative stress (OXS), followed by a substantial synthesis of the involved oxidative cascades into specific and functional, trauma-related pathways. The bulk of the evidence suggests an imbalance of pro-/anti-oxidative mechanisms under conditions of traumatic stress, respectively leading to a systemic oxidative dysregulation accompanied by toxic oxidation byproducts. Yet, there is substantial heterogeneity in findings probably relative to confounding, trauma-related parameters, as well as to the equivocal directionality of not only the involved oxidative mechanisms but other homeostatic ones. Accordingly, we also discuss the trauma-related OXS findings within the broader spectrum of systemic interactions with other major influencing systems, such as inflammation, the hypothalamic-pituitary-adrenal axis, and the circadian system. We intend to demonstrate the inherent complexity of all the systems involved, but also put forth associated caveats in the implementation and interpretation of OXS findings in trauma-related research and promote their comprehension within a broader context.

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Section: Circadian Dysregulation and Melatoninmentioning

confidence: 98%

Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review

2021

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“…Moreover, melatonin was found to augment the general immunity by attenuating oxidative load associated with age in hamsters by 25 μg/100 g body weight for 30 days [201]. It was reported that melatonin could alleviate oxidative damage and suppress the immune status induced by stressful factors via its membrane receptor expression MT1 and MT2 in wild birds [202]. Due to its anti-inflammatory properties, melatonin could suppress systemic innate immune activation during sepsis in mice both in vivo and in vitro by blocking the NF-κB/NOD-like receptor P3 (NLRP3) connection through a sirtuin1-dependent pathway [154].…”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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“…In the urban environment, stressors such as light, noise and chemical pollution may influence the oxidative balance through their effect on hormones like melatonin and corticosterone (Isaksson, 2015). In fact previous studies have shown that melatonin, which is also an antioxidant, and corticosterone, which has pro-oxidant effects, can affect the oxidative status (Yadav & Haldar, 2014;Costantini et al, 2011) together with chemical pollutants (Isaksson, 2010). Furthermore, in an urban environment, stressors rarely act in isolation.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Neither artificial light at night, anthropogenic noise nor distance from roads are associated with oxidative status of nestlings in an urban population of songbirds

Casasole

Raap

Costantini

et al. 2017

Comparative Biochemistry and Physiology Part A: Molecular &

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Increasing urbanization is responsible for road-related pollutants and causes an unprecedented increase in light and noise pollution, with potential detrimental effects for individual animals, communities and ecosystems. These stressors rarely act in isolation but studies dissecting the effects of these multiple stressors are lacking. Moreover, studies on urban stressors have mainly focused on adults, while exposure in early-life may be detrimental but is largely ignored. To fill this important knowledge gap, we studied if artificial light at night, anthropogenic noise and road-related pollution (using distance from roads as a proxy) explain variation in oxidative status in great tit nestlings (Parus major) in an urban population. Artificial light at night, anthropogenic noise and distance from roads were not associated with variation of the nine studied metrics of oxidative status (superoxide dismutase-SOD-, glutathione peroxidase-GPX, catalase-CAT-, non-enzymatic total antioxidant capacity-TAC-, reduced glutathione-GSH-, oxidized glutathione-GSSG-, ratio GSH/GSSG, protein carbonyls and thiobarbituric acid reactive substances-TBARS). Interestingly, for all oxidative status metrics, we found that there was more variation in oxidative status among individuals of the same nest compared to between different nests. We also showed an increase in protein carbonyls and a decrease of the ratio GSH/GSSG as the day advanced, and an increase of GPX when weather conditions deteriorated. Our study suggests that anthropogenic noise, artificial light at night and road-related pollution are not the most important sources of variation in oxidative status in great tit nestlings. It also highlights the importance of considering bleeding time and weather conditions in studies with free-living animals.

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Experimentally induced stress, oxidative load and changes in immunity in a tropical wild bird, Perdicula asiatica: involvement of melatonin and glucocorticoid receptors

Cited by 13 publications

References 45 publications

Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review

Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review

Dietary Sources and Bioactivities of Melatonin

Neither artificial light at night, anthropogenic noise nor distance from roads are associated with oxidative status of nestlings in an urban population of songbirds

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