Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-BENS)

Tanaka, Hiroki; Sakurai, Yoshinori; Suzuki, Minoru; Masunaga, Shin‐ichiro; Mitsumoto, T.; Fujita, K.; Kashino, Genro; Kinashi, Yuko; Liu, Y.; Takada, Masashi; Ono, Kouji; Maruhashi, Akira

doi:10.1016/j.apradiso.2011.03.020

Cited by 118 publications

(72 citation statements)

References 4 publications

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“…The major advantages of accelerator-based BNCT over reactorbased neutron sources are the possibility of their installation in hospitals, lower radiation hazards, and simple licensing, installation, and maintenance. At the Kyoto University Research Reactor Institute in Japan, a cyclotron-based neutron source has been developed for a phase I clinical trial to treat patients with recurrent GBM (31). We expect that in the near future, accelerator-based BNCT may replace treatments using reactor-based neutron sources.…”

Section: Future Perspectivesmentioning

confidence: 99%

Boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma: Comparison of clinical results obtained with BNCT and conventional treatment

et al. 2014

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: The purpose of this study was to evaluate the clinical outcome of boron neutron capture therapy (BNCT) and conventional treatment in patients with newly diagnosed glioblastoma. Since 1998 we treated 23 newly-diagosed GBM patients with BNCT without any additional chemotherapy. Their median survival time was 19.5 months ; the 2-, 3-, and 5-year survival rates were 31.8% %, 22.7% %, and 9.1% %, respectively. The clinical results of BNCT in patients with GBM are similar to those of recent conventional treatments based on radiotherapy with concomitant and adjuvant temozolomide.

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Section: Future Perspectivesmentioning

confidence: 99%

Boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma: Comparison of clinical results obtained with BNCT and conventional treatment

et al. 2014

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“…This value was reported to be about twice as large as that obtained by their research reactor. 24 The clinical trial will be started soon.…”

Section: Boron Neutron Capture Therapymentioning

confidence: 99%

A review of ion sources for medical accelerators (invited)

Muramatsu¹,

Kitagawa²

2012

Review of Scientific Instruments

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There are two major medical applications of ion accelerators. One is a production of short-lived isotopes for radionuclide imaging with positron emission tomography and single photon emission computer tomography. Generally, a combination of a source for negative ions (usually H- and/or D-) and a cyclotron is used; this system is well established and distributed over the world. Other important medical application is charged-particle radiotherapy, where the accelerated ion beam itself is being used for patient treatment. Two distinctly different methods are being applied: either with protons or with heavy-ions (mostly carbon ions). Proton radiotherapy for deep-seated tumors has become widespread since the 1990s. The energy and intensity are typically over 200 MeV and several 1010 pps, respectively. Cyclotrons as well as synchrotrons are utilized. The ion source for the cyclotron is generally similar to the type for production of radioisotopes. For a synchrotron, one applies a positive ion source in combination with an injector linac. Carbon ion radiotherapy awakens a worldwide interest. About 6000 cancer patients have already been treated with carbon beams from the Heavy Ion Medical Accelerator in Chiba at the National Institute of Radiological Sciences in Japan. These clinical results have clearly verified the advantages of carbon ions. Heidelberg Ion Therapy Center and Gunma University Heavy Ion Medical Center have been successfully launched. Several new facilities are under commissioning or construction. The beam energy is adjusted to the depth of tumors. It is usually between 140 and 430 MeV/u. Although the beam intensity depends on the irradiation method, it is typically several 108 or 109 pps. Synchrotrons are only utilized for carbon ion radiotherapy. An ECR ion source supplies multi-charged carbon ions for this requirement. Some other medical applications with ion beams attract developer's interests. For example, the several types of accelerators are under development for the boron neutron capture therapy. This treatment is conventionally demonstrated by a nuclear reactor, but it is strongly expected to replace the reactor by the accelerator. We report status of ion source for medical application and such scope for further developments.

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“…There are several other projects based on this reaction. There is a 30 MeV proton cyclotron installed at Kyoto University, 4 which produces very high energy neutrons of up to 28 MeV, likely to activate parts of the facility. There is also an RFQ-DTL being installed at Ibaraki prefecture, near Tsukuba, intended to work with an 8 MeV proton beam 7 (see Table 1), producing neutrons of up to 6 MeV.…”

Section: B Reactionsmentioning

confidence: 99%