Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid–collagen (PGA–collagen) tube

Nakamura, Tasuo; Inada, Yûji; Fukuda, Susumu; Yoshitani, Makoto; Nakada, Akira; Itoi, Shin-ichi; Kanemaru, Shin‐ichi; Endo, Kaori; Shimizu, Yasuhiko

doi:10.1016/j.brainres.2004.08.040

Cited by 146 publications

(107 citation statements)

References 42 publications

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“…When there are significant gaps created by retraction or by extensive nerve damage resulting in loss of a nerve segment, grafts are required (Moroder et al, 2011). However, nerve autografts have some disadvantages, such as availability of donor tissue, the formation of painful neuromas in the donor area, and loss of donor nerve function (Bockelmann et al, 2011;Evans, 2000;Moroder et al, 2011;Nakamura et al, 2004;Pierucci, de Duek, & de Oliveira, 2008).…”

Section: Introductionmentioning

confidence: 99%

Sciatic nerve repair using poly(ε‐caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Sciatic nerve repair using poly(ε‐caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene

et al. 2017

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“…The availability of autologous nerve transplants is especially limited when a large amount of grafting material is needed as in massive peripheral nerve lesions, because it requires sacrifices of healthy nerves (Lundborg, 2004). There are experimental and clinical approaches to use synthetic guidance channels in peripheral nerve regeneration (Nakamura et al, 2004). However, the golden standard is still transplantation of autologous nerve grafts as they provide a scaffold which contains Schwann cell basal laminae and growth factor constituting optimal growth substrate and environment for regrowing axons (Ansselin et al, 1997;Bunge, 1993;Lundborg, 2004).…”

Section: Introductionmentioning

confidence: 99%

Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms

Haastert

Lipokatic

Fischer

et al. 2006

Neurobiology of Disease

110

118

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“…In comparison with autografting, this composite nerve conduit enabled superior functional recovery and shortened recovery period [54] .…”

Section: Bio-interface Of Traditional Biopolymers In Neuroregenerationmentioning

confidence: 98%

“…[53] . [54] . In the absence of neurotrophin (PPy/pTS), very few neurites were observed from explants, while explants grown on PPy/pTS containing neurotrophin demonstrated increased numbers of sprouting neurites.…”

Section: Acknowledgementmentioning

confidence: 99%

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Weng

Diao

et al. 2015

Adv Materials Inter

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Nerve system diseases like Parkinson's disease, Huntington's disease, Alzheimer's disease, etc. seriously affect thousands of patients' lives every year, making them suffer from pains and inconvenience. Recently, biointerfaces between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carriers and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers. In this paper we mainly focus on reviewing the bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composite materials. These advanced polymers can provide combined interfacial stimulations including interfacial external neurotrophic factors (NTFs) delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed. Nerve system diseases like Parkinson's disease, Huntington's disease and Alzheimer's disease etc. seriously affect thousands of patients' lives every year, making the patients suffer from pains and inconvenience brought about by these diseases. Recently, bio-interface between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carrier and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers.In this paper we mainly focus on reviewing bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composites materials.. These advanced polymers can provide combined interfacial stimulations including interfacial NTFs delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed.

show abstract

Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid–collagen (PGA–collagen) tube

Cited by 146 publications

References 42 publications

Sciatic nerve repair using poly(ε‐caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene

Sciatic nerve repair using poly(ε‐caprolactone) tubular prosthesis associated with nanoparticles of carbon and graphene

Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

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