Experimental study of effectiveness of local application of electroneurostimulation, cortexin and methylprednisolone in acute spinal cord injury.

The Method of Multilevel Decompression of Thoracic Spine with the Durotomy and the Local Administration of Cortexin in the Setting in Intradural Space in the Patients with Spinal Cord Injury

“…We assume that when the dynamics of recovery was not observed, predominant factor was the primary failure of the zone of spinal cord contusion. We developed safe and effective method, which provides an opportunity to reduce the secondary alterations of affected spinal cord and thereby improve the quality of life in patients with the spinal cord injury [14,15].…”

“…The mechanism of action of Cortexin is principally associated with its metabolic activity: it passes freely through the blood-brain barrier and so regulates the balance between inhibitory and excitatory neurotransmitters, serotonin and dopamine levels, has GABA-ergic effect and antioxidative activity, normalizes the Glutamate-Calcium Cascades, slows down the processes of apoptosis. Pharmacological action of Cortexin was studied in the setting of the treatment of craniocerebral injury and its consequences, encephalopathy of different origin, acute and chronic encephalitis and encephalomyelitis, being a part of complex therapy in epilepsy and in different forms of infantile cerebral paralysis in each case the significant clinical effect of the medicinal product was observed [14,15].…”