Experimental study in a rabbit model of ischemia-reperfusion lung injury during cardiopulmonary bypass

Kuratani, Tohru; Matsuda, Hikaru; Sawa, Yoshiki; Kaneko, M; Nakano, Susumu; Kawashima, Yasunaru

doi:10.1016/s0022-5223(19)34999-2

Cited by 54 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, multiple studies have described that because of unique structure and function, the lung becomes a vulnerable target during IR injury (Adkins et al, 1990;Esme et al, 2006). Interestingly, accumulation of toxic metabolites from aerobic metabolism and free radical injury may occur when the lungs are inflated with oxygen (Haniuda et al, 1995;Kuratani et al, 1992;Watanabe et al, 1997). Alveolar oxygen helps maintain aerobic metabolism and prevents hypoxic ROS formation (Eckenhoff et al, 1992;Fisher & Dodia, 1981).…”

Section: Ischemia-reperfusion Injurymentioning

confidence: 99%

Lung ischemia–reperfusion injury: implications of oxidative stress and platelet–arteriolar wall interactions

Ovechkin

Lominadze²,

Sedoris

et al. 2007

Archives of Physiology and Biochemistry

100

View full text Add to dashboard Cite

Pulmonary ischemia-reperfusion (IR) injury may result from trauma, atherosclerosis, pulmonary embolism, pulmonary thrombosis and surgical procedures such as cardiopulmonary bypass and lung transplantation. IR injury induces oxidative stress characterized by formation of reactive oxygen (ROS) and reactive nitrogen species (RNS). Nitric oxide (NO) overproduction via inducible nitric oxide synthase (iNOS) is an important component in the pathogenesis of IR. Reaction of NO with ROS forms RNS as secondary reactive products, which cause platelet activation and upregulation of adhesion molecules. This mechanism of injury is particularly important during pulmonary IR with increased iNOS activity in the presence of oxidative stress. Platelet-endothelial interactions may play an important role in causing pulmonary arteriolar vasoconstriction and post-ischemic alveolar hypoperfusion. This review discusses the relationship between ROS, RNS, P-selectin, and platelet-arteriolar wall interactions and proposes a hypothesis for their role in microvascular responses during pulmonary IR.

show abstract

Section: Ischemia-reperfusion Injurymentioning

confidence: 99%

Lung ischemia–reperfusion injury: implications of oxidative stress and platelet–arteriolar wall interactions

Ovechkin

Lominadze²,

Sedoris

et al. 2007

Archives of Physiology and Biochemistry

100

View full text Add to dashboard Cite

show abstract

“…[7][8][9] Experimental studies dem-onstrated that with less deprivation of blood flow in the pulmonary arteries, there is less severe subsequent lung injury. [10][11][12] On the other hand, the role of bronchial flow in preventing lung ischemia is still controversial. [13][14] Serraf and coworkers 15 demonstrated, in a piglet model, that lowflow lung perfusion during total CPB prevents depletion of tissue adenosine triphosphate stores and PaO 2 .…”

Section: Discussionmentioning

confidence: 99%

Surgical repair of acute type a aortic dissection: continuous pulmonary perfusion during retrograde cerebral perfusion prevents lung injury in a pilot study

Santo

Romano

Amarelli

et al. 2003

The Journal of Thoracic and Cardiovascular Surgery

View full text Add to dashboard Cite

show abstract

“…First, the lungs are kept perfused, which allows them to function in the homeostatic prostaglandin and thromboxane balance ( 15, 16). Second, lung perfusion avoids tissue anoxia that produces leukoplaquetary aggregation and capillary obstruction and ensuing respiratory distress ( 17). Third, the oxygenator represents a large surface area for blood contact with foreign material.…”

Section: Discussionmentioning

confidence: 99%

A Simplified Single Pump Circuit for Cardiac Bypass with Autogenous Oxygenation

Marques

Cestari

et al. 1999

Artificial Organs

View full text Add to dashboard Cite

A simplified extracorporeal circulation (ECC) assemblage with autogenous oxygenation (AO) using a single centrifugal pump was tested in dogs. The transpulmonary gradient was obtained by increasing pressure in the right atrium through volume expansion and decreasing it in the left atrium by collecting the blood from the pulmonary veins in a reservoir placed below the level of the animal, generating a siphon effect. This arrangement dispenses with a right side pump. The heart was electrically fibrillated after perfusion was started and defibrillated at the end of the bypass. This ECC circuit allowed the maintenance of adequate hemodynamic and blood gas parameters during the bypass. The operating field and the mobility of the heart were equivalent to that of conventional cardiopulmonary bypass (CPB). We conclude that the use of a single centrifugal pump simplifies the autogenous oxygenation approach, making it a practical choice for the coronary artery bypass graft (CABG) procedure.

show abstract

Experimental study in a rabbit model of ischemia-reperfusion lung injury during cardiopulmonary bypass

Cited by 54 publications

References 13 publications

Lung ischemia–reperfusion injury: implications of oxidative stress and platelet–arteriolar wall interactions

Lung ischemia–reperfusion injury: implications of oxidative stress and platelet–arteriolar wall interactions

Surgical repair of acute type a aortic dissection: continuous pulmonary perfusion during retrograde cerebral perfusion prevents lung injury in a pilot study

A Simplified Single Pump Circuit for Cardiac Bypass with Autogenous Oxygenation

Contact Info

Product

Resources

About