Experimental studies on intra-abdominal adhesions

Iijima, Noboru; Inoue, Kichi; Yamamoto, Takashi; Gomi, Fujiko

doi:10.1136/pgmj.46.535.278

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Intraperitoneal adhesions are caused by various agents that injure the peritoneum, including infection, foreign bodies, ischemia, congestion, and surgical dissection [1][2][3][4][5][6][7][8]. When adhesions cause intestinal obstruction, surgical lysis of the adhesions causes further peritoneal damage and new adhesions that are often more widespread than the ones which have undergone surgical lysis.…”

Section: Discussionmentioning

confidence: 99%

The role of topically applied dexamethasone in preventing peritoneal adhesions: Experimental and clinical studies

Shikata

Yamaoka

1977

World j. surg.

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In an experimental study, the serosa of the ileum of rats was injured with silver nitrate, and the effect of topical application of a dexamethasone solution on subsequent formation of intraperitoneal adhesions was compared to the effect of saline irrigation (controls). There was a highly significant difference (p < 0.01) in the incidence and grade of adhesions observed 1 and 4 weeks postoperatively between the control and dexamethasone-treated rats. Furthermore, adhesive intestinal strictures were observed in the control rats, but not in the animals that received dexamethasone. Administration of dexamethasone at the time of laparotomy and again 1 week postoperatively was most effective in preventing adhesions.In a clinical trial, topical application of dexamethasone at the time of laparotomy for recurrent adhesive intestinal obstruction in 34 patients was associated with a 9% incidence of further recurrence of adhesive obstruction over a 1-6 year follow-up period, compared to a 31% incidence of recurrent obstruction in 13 similar patients who received only saline irrigation, lntraperitoneal administration of dexamethasone at the time oflaparotomy and for the first 2 days postoperatively in 5 patients was followed by no recurrence of obstruction.Intraperitoneal adhesions are believed to occur in 80 to 90% of patients following laparotomy [1]. Surgical lysis of adhesions tends to create new adhesions in wider areas than before [1-3], and intestinal obstruction due to adhesions often recurs. Effective measures for preventing adhesions are greatly needed but, thus far, no such measures have gained wide acceptance. The studies in this report were aimed at evaluating the effectiveness of topical application of dexamethasone in preventing postoperative intraperitoneal adhesions.

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Section: Discussionmentioning

confidence: 99%

The role of topically applied dexamethasone in preventing peritoneal adhesions: Experimental and clinical studies

Shikata

Yamaoka

1977

World j. surg.

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“…Simple laparotomy or laparoscopy with or without handling of the intestine, abrasion of cecum with or without abrasion of other organs, abrasion of the peritoneum, abrasion of the abdominal wall, intraperitoneal injection of various substances, drains, and modification of these experimental techniques by changing force, time, suturing materials, gloves, use of electrocautery, healing agents, meshes, inflammation agents and instrumentation have all been applied to replicate postoperative adhesive bowel obstruction [23,[143][144][145][146][147][148][149][150][151][152][153]. Authors have also published their experiments on how radiation, desiccation, thermal injury, bleeding, ischemia, endometriosis, cancer, pain, and peritoneal irritation affect the formation of adhesions [23,[154][155][156][157][158]. The main drawback of all of these techniques is the inability to standardize them in an objective countable method.…”

Section: Partial Mechanical Obstructionmentioning

confidence: 99%

Experimental Animal Models for Studying Intestinal Obstruction

Mavrigiannaki,

Georgopoulos

2024

Animal Models in Medical Research [Working Title]

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Understanding the pathophysiology of intestinal obstruction and exploring potential therapeutic interventions heavily relies on the utilization of experimental animal models. This book chapter provides a comprehensive overview of various animal models employed in the study of surgically induced intestinal obstruction. From rodents to large animals, a range of experimental setups and methodologies are discussed, each offering unique advantages and insights into the complexities of this condition. The chapter provides a guide for researchers aiming to investigate intestinal obstruction, reviewing all aspects of an experimental protocol. Ethical and regulatory regulations, anatomical and physiological differences among species, and surgically induced experimental intestinal obstruction are reviewed. The existing experimental animal models are evaluated regarding their reproducibility and efficacy, as many published models prove difficult to replicate in the laboratory or lack crucial information for researchers. A chapter of this nature would greatly benefit the research community and pave the way for future studies.

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