The Effect of Vitamin E on Experimentally Induced Peritoneal Adhesions in Mice

Kagoma, Peter; Burger, Steven N.; Seifter, Eli; Levenson, Stanley Μ.; Demetriou, Achilles A.

doi:10.1001/archsurg.1985.01390320073015

Cited by 39 publications

(33 citation statements)

References 27 publications

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“…[14,15] Several pharmacological agents, such as high doses of vitamin E and simvastatin, were discovered to have a high efficacy in adhesion prevention. [16][17][18] Taurolidine is an antimicrobial agent used for intra-abdominal adhesion formation and sepsis prevention in experimental and clinical trials. In previous studies, the blocking effects of taurolidine on fibrin deposition have been described.…”

Section: Discussionmentioning

confidence: 99%

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Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Kurt¹,

Sıkar

Kaptanoğlu³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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Section: Discussionmentioning

confidence: 99%

“…Pharmacological agents, such as corticosteroids and vitamin E, has adhesion preventive effects at high doses. [14][15][16][17] Future studies may show similar impacts of taurolidine and icodextrin. In literature, there is a study in which in 2 ml (0.04 g) of taurolidine 2% solution has been used as an adhesion preventative.…”

Section: Discussionmentioning

confidence: 99%

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Kurt¹,

Sıkar

Kaptanoğlu³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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“…Free oxygen radicals such as superoxide, peroxide and hydroxyl radicals have the potential to oxidize polyunsaturated fatty acids. Oxidation of fatty acids would result in peroxidation of cell membrane lipids and accordingly in the process that would enhance vascular permeability [8]. This process causes formation of serosanguineous exudate.…”

Section: Discussionmentioning

confidence: 99%

Could the Material Wrapped Around the Heart Prevent Adhesion? A Case Report

2015

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Adhesions around the heart might enhance the difficulty in performing the second heart surgery. These fibrin adhesions between epicardium and pericardium increase not only the cost, but also bleeding, duration of surgery and poor clinical outcomes. A patient, who had undergone mitral commissurotomy with the assistance of heart-lung machine (CPB) in 1998 and in whom a material that was considered to reduce adhesion had been wrapped around the heart, underwent cardiac re-surgery in 2014. No detailed information could be obtained about film barrier performed during the first surgery from the center where the surgery was performed. In our clinic, we observed the effect of the material wrapped around the heart during mitral valve replacement on adhesion.

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“…It demonstrates numerous in vitro effects such as (1) acting as an anti-oxidant by cleaning the free radicals created locally and inhibiting the enzymatic peroxidase and non-enzymatic lipids, thus protecting the cell membranes from oxidative degradation 30,31 , (2) acting as an anti-inflammatory agent due to the inhibition of cyclooxygenase-2 (COX-2) and endogen conversion of the arachadonic acid in PGE 2 and PGF 2" 16 , and (3) acting as an anticoagulant by inhibiting the aggregation of platelets and maintaining their stability. Vitamin E inhibits the formation of thrombus, and consequently reduces the formation of fibrin, which is thought to play an important role in the formation of peritoneal adhesions 30,32 , and has an anti-fibroblastic effect, inhibiting the action of TGF-beta, a powerful fibrosis inductor, while still playing a role in diminishing the production of collagen 16 .…”

Section: Discussionmentioning

confidence: 99%

Preventing intraperitoneal adhesions with vitamin E and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats

Corrales¹,

Corrales²,

Schirmer³

2008

Acta Cir. Bras.

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Purpose:To compare the effectiveness of intraperitoneally administered vitamin E with the sodium hyaluronate/ carboxymethylcellulose membrane (HA/CBMC) in preventing postoperative intraperitoneal adhesion formation. Methods: Sixty Wistar rats underwent a laparotomy and adhesions were induced (IA). The animals were divided into four groups: group 1, control (IA); group 2 (IA + Vitamin E): group 3 (IA+HA/CBMC) and group 4 (IA+ Vitamin E + HA/CBMC). The Vitamin E (groups 2 and 4) and HA/CBMC (groups 3 and 4) were administered intraperitoneally before the abdominal wall was closed. After 30 days, adhesions were classified by an independent surgeon. Results: Three animals died; one from group 3 and two from group 4. All control animals had substantial adhesions compared with unsubstantial adhesions observed in 11/15 in group 2 (P = 0.000), 11/14 in group 3 (P = 0.001), and 10/13 in group 4 (P = 0.000). Conclusion: Vitamin E, administered intraperitoneally, is as effective as HA/CBMC in preventing postoperative adhesions.Key words: Adhesions. Vitamin E. Carboxymethylcellulose. Rats. RESUMOObjetivo: Comparar a efetividade da Vitamina E e da membrana de Carboximetilcelulose/Hialuronato de Sódio (CBMC/HA) na prevenção da formação de aderências intraperitoneais pós-operatórias. Métodos: Sessenta ratos Wistar foram submetidos à laparotomia para indução de aderências (IA) com abrasão do ceco seguido de aplicação de álcool absoluto e sutura com fio de seda no peritônio parietal. Os animais foram divididos em quatro grupos: 1 controle ( IA ); 2 ( IA + Vitamina E ); 3( IA + CBMC/HA ) e 4 ( IA + Vitamina E + CBMC/HA ). A Vitamina E ( grupos 2 e 4 ) e CBMC/HA ( grupos 3 e 4 ) foram administrados intraperitonealmente antes do fechamento da parede. Os ratos foram sacrificados em 30 dias e as aderências foram classificadas por cirurgião independente. Resultados: Três animais morreram, sendo um do grupo 3 e dois do grupo 4. Todos os animais do grupo controle ( 1 ) tiveram aderências substanciais, comparados com aderências insubstanciais em 11/15 no grupo 2 ( p = 0,000 ), 11/14 no grupo 3 ( p = 0,001 ) e 10/13 no grupo 4 ( p = 0,000 ). Conclusão: A Vitamina E administrada de maneira intraperitoneal é tão eficaz quanto a CBMC/HA na prevenção da formação de aderências pós-operatórias.

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The Effect of Vitamin E on Experimentally Induced Peritoneal Adhesions in Mice

Cited by 39 publications

References 27 publications

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Could the Material Wrapped Around the Heart Prevent Adhesion? A Case Report

Preventing intraperitoneal adhesions with vitamin E and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats

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