Experimental Animal Models for Studying Intestinal Obstruction

Abstract

Understanding the pathophysiology of intestinal obstruction and exploring potential therapeutic interventions heavily relies on the utilization of experimental animal models. This book chapter provides a comprehensive overview of various animal models employed in the study of surgically induced intestinal obstruction. From rodents to large animals, a range of experimental setups and methodologies are discussed, each offering unique advantages and insights into the complexities of this condition. The chapter provides a guide for researchers aiming to investigate intestinal obstruction, reviewing all aspects of an experimental protocol. Ethical and regulatory regulations, anatomical and physiological differences among species, and surgically induced experimental intestinal obstruction are reviewed. The existing experimental animal models are evaluated regarding their reproducibility and efficacy, as many published models prove difficult to replicate in the laboratory or lack crucial information for researchers. A chapter of this nature would greatly benefit the research community and pave the way for future studies.