Experimental studies on differential hypothermia of the liver

Mito, Michio; Tamaki, Akira; Kon, Tadamasa; Ohira, Suguru; Mikami, Jiro

doi:10.1016/s0022-4804(65)80088-9

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…However, the reduction in oxygen consumption may differ between organs and depends on the model used. A total body hypothermia of 23°C for 6 h did not change hepatic oxygen consumption in dogs (18), whereas another investigation using an extracorporeal circuit for cooling reported a decrease in oxygen consumption of the liver to 36% when the temperature was decreased from 37 to 26°C (19).…”

Section: Discussionmentioning

confidence: 99%

Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats

Behrends

Hirose

Serkova

et al. 2006

Liver International

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Section: Discussionmentioning

confidence: 99%

Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats

Behrends

Hirose

Serkova

et al. 2006

Liver International

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“…Early studies showed that total body cooling to a rectal temperature as low as 23°C for up to 12 h does not adversely affect liver function (10). Subsequently, it was shown that extracorporeal cooling of the liver to 25°C resulted in a 36% reduction in the oxygen consumption by the liver (22). More recent reports suggest that hepatic hypothermia reduces liver ATP levels, resulting in a prolongation of hepatocellular viability in ischemic tissues (8).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of hypothermic protection against ischemic liver injury in mice

Kato¹,

Singh

McLeish

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Mechanisms of hypothermic protection against ischemic liver injury in mice. Am J Physiol Gastrointest Liver Physiol 282: G608-G616, 2002. 10.1152/ajpgi.00454.2001.-Hepatic hypothermia can safely prolong the duration of hepatic inflow occlusion during complex liver resectional surgeries. The mechanism(s) by which hypothermia protects against this form of liver ischemia-reperfusion injury are not completely understood. In this study, we sought to determine whether hypothermia protects against ischemia-reperfusion injury by altering the hepatic inflammatory response. Mice undergoing 90 min of partial hepatic ischemia followed by up to 8 h of reperfusion had their body temperatures regulated at 35-37°C (normothermic) or unregulated, in which rectal temperature dropped as low as 25°C by the end of ischemia (hypothermic). Hypothermic mice had less liver injury vs. normothermic mice, as assessed histologically, by serum transaminase levels (89% decrease), and by liver wet-to-dry weight ratios (91% decrease). Neutrophil accumulation was absent in hypothermic mice (99% reduction vs. normothermic mice). Production of the proinflammatory cytokines tumor necrosis factor-␣, interleukin-1␤, and macrophage inflammatory protein-2 were reduced by up to 92%. Activation of the transcription factor nuclear factor-B was not reduced in hypothermic mice, but activation of c-Jun NH 2-terminal kinase (JNK) and the transcription factor activator protein (AP)-1 were greatly diminished. These data suggest that hypothermia suppresses the hepatic inflammatory response through selective inhibition of JNK and AP-1.

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“…Oxygen free radicals are usually produced by the aerobic metabolism of living cells. An overproduction of these radicals has been reported in ischemic/reperfused organs, leading to a high degree of tissue damage (6,12,21,22) . Prevention of these deleterious effects, by the administration of antioxidative substances has been attempted in organ transplantation and surgical emergencies (17,23) .…”

Section: Discussionmentioning

confidence: 99%