Experimental Studies on a New Highly Porous Hydroxyapatite Matrix for Obliterating Open Mastoid Cavities

Abstract

Our results confirm the favorable qualities of the new ceramic reported in association with current maxillofacial literature. Conventional HA granules used for mastoid obliteration to date often showed problems with prolonged inflammatory reactions and, finally, extrusions. In contrast to those ceramics, the new material seems to induce more osteoneogenesis and undergoes early resorption probably due to its high porosity. Overall, it is similar to the bovine bone substance tested on the opposite ear in each animal. Further clinical studies may reveal whether NanoBone can be an adequate material for obliterating open mastoid cavities in patients.

Bone formation in mono cortical mandibular critical size defects after augmentation with two synthetic nanostructured and one xenogenous hydroxyapatite bone substitute – in vivo animal study

“…The density of the calcium phosphate matrix amounts to 0.5-0.7 g/cm 3 with a porosity of 60-80% (Gauthier et al 1998;Gerber et al 2000). Promising results in earlier animal and clinical studies were reported (Henkel et al 2004(Henkel et al , 2006Punke et al 2008Punke et al , 2009. The hydroxyapatite particles of NHA2 have a flat shape with an average diameter of 18 nm.…”

“…, ; Punke et al. , ). The hydroxyapatite particles of NHA2 have a flat shape with an average diameter of 18 nm.…”

Obliteration of temporal dorsal bulla in guinea pigs using different types of calcium phosphate

“…After Zö llner and colleagues reported obliteration of the mastoid air cell with porous tricalcium phosphate ceramic, there were several reports about mastoid obliteration using glass ionomer cement, demineralized bone matrix, bioactive glass ceramic particles, and hydroxyapatite [6][7][8][9][10][11][12][13][14][15][23][24][25][26][27][28][29]. Among them, a calcium phosphate material has been widely used for bone replacement because of its good biocompatibility and osteoconductivity.…”

“…Clinically bone, autologous fat, cartilage and several local flaps are used to obliterate the mastoid cavity [1][2][3][4][5]. Some alloplastic materials such as hydroxyapatite and demineralized bone, have been used to fill the bony cavity defect [6][7][8][9][10][11][12][13][14][15]. However, some autologous materials or flaps can be dissolved over time and other alloplastic materials may not to be suitable to use because of their appearances and possibility for a foreign body reaction [3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Biomaterials Applicable for Alveolar Sockets Preservation: In Vivo and In Vitro Studies

“…Furthermore, signs of angiogenesis could be observed (Abshagen et al 2009). Vascularization as well as osteoneogenesis after implantation of NanoBone ® was observed using guinea pigs (Punke et al 2008). Our own group could establish a FE model of remodelling processes occurring in a bone area provided with bone graft substitutes .…”