Experimental Sphincter for Short-Bowel Syndrome

Grier, R. L.

doi:10.1001/archsurg.1971.01350030041011

Cited by 14 publications

(5 citation statements)

References 25 publications

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“…This result is in marked contrast to the literature. However, in all comparative experimental studies, there were late postoperative deaths due to bad function [5,7], while in this study no deaths after the 10th postoperative day occurred. Therefore, the results published might have been worse if all animals had survived as in the present study.…”

Section: Discussioncontrasting

confidence: 47%

“…Artificial valves significantly improved transit time, body weight and survival rates in rats [5], dogs [6][7][8] and humans [9] after massive small bowel resection. The question arises whether this procedure simply dilates the bow-Willis/Klosterhalfen/Titkova/Anurov/ Polivoda/Max/Öttinger/Schumpelick el, as occurs in acute or chronic bowel obstruction, or whether there is an increased intestinal adaptation with induction of real bowel growth [4,7], and whether this procedure could increase the absorptive capacity of the small intestinal remnant [8].…”

Section: Discussionmentioning

confidence: 99%

“…The question arises whether this procedure simply dilates the bow-Willis/Klosterhalfen/Titkova/Anurov/ Polivoda/Max/Öttinger/Schumpelick el, as occurs in acute or chronic bowel obstruction, or whether there is an increased intestinal adaptation with induction of real bowel growth [4,7], and whether this procedure could increase the absorptive capacity of the small intestinal remnant [8]. The present results show that the serosal diameter was unchanged in PRV, while it was significantly increased in DRV.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, to induce gut dilatation and subsequent growth, partial obstruction of the small intestine was perfomed using artificial valves in order to increase the absorptive mucosal surface [1,4]. Artificial valves significantly improved transit Willis/Klosterhalfen/Titkova/Anurov/ Polivoda/Max/Öttinger/Schumpelick time, body weight and survival in rats [5], dogs [6][7][8] and humans [4]. However, it is still unclear whether this procedure simply dilates the bowel, as occurs in acute bowel obstruction, or whether real bowel growth is induced [4,9].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Artificial Valves on Intestinal Adaptation in the Short-Bowel Syndrome: An Integrated Study of Morphological and Functional Changes in Rats

Willis¹,

Klosterhalfen²,

Titkova

et al. 2000

Eur Surg Res

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Two-third-resections of the proximal or distal small bowel with and without artificial valves were performed in rats. Intestinal adaptation led to a significant increase in bowel diameter, villus height and villus diameter and consequently in absorptive mucosal surface area per unit of serosal area. Additional artificial valve construction did not affect the calculated mucosal surface area after proximal resection, while it significantly decreased the absorptive area by the occurrence of large, plump villi after distal resection. There was no change in small-intestinal absorption of water, glucose and electrolytes per unit mucosa with valve construction. DNA cytometry showed that artificial valves led to mucosal hyperplasia without hypertrophy. These morphological changes coincided with a significant increase in basal and stimulated gastrin release. The body weight was unchanged or even worse in the valve groups than after resection alone, despite a significantly prolonged transit time. Therefore, in our study, artificial valves did not result in functional improvements after small intestinal resections.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Artificial Valves on Intestinal Adaptation in the Short-Bowel Syndrome: An Integrated Study of Morphological and Functional Changes in Rats

Willis¹,

Klosterhalfen²,

Titkova

et al. 2000

Eur Surg Res

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“…In an animal study by Sarr et al [16], there was no clear correlation found between the transit time and jejunal absorption. Other studies have also shown an increase in transit time with construction of intestinal valves, following massive small bowel resec tion [1,6,8]. Although weight loss was not prevented by the presence of a nipple valve, these dogs were able to form semisolid stools, which was similar to dogs with an intact ileocecal valve.…”

Section: Body Weightmentioning

confidence: 70%

Long-Term Effects on Nipple Valve afterMassive Small Bowel Resection on Transit Time and Body Weight

Chardavoyne¹,

Gluck²,

Stein³

et al. 1988

Dig Surg

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Four months after a 70% distal small bowel resection, transit time was decreased by 51.5 % in dogs with an intact ileocecal valve, 68.8% with a surgically constructed nipple valve, and 79.9% with a simple ileocecal anastomosis. Without an intact ileocecal valve, weight loss occurred. Stools were semiformed when a nipple valve or ileocecal valve was present, but liquid with a simple ileocecal anastomosis. This study suggests that the construction of a nipple valve may prevent some complications related to the loss of the ileocecal valve and massive small bowel resection.

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