Experimental production of “L.E.” Cells

Moyer, John B.; Fisher, George S.

doi:10.1093/ajcp/20.11.1011

Cited by 15 publications

(2 citation statements)

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“…It is also possible that some of the contacts may be infected without developing fully characteristic blood changes; this may have happened, for instance, in the second brother of Case 1. The incidence among members of the same family has been observed before (Smith, 1944;Moyer and Fisher, 1950) and is well illustrated by the present cases. Incubation Period.-This has been estimated as being between 12 and 21 days (Smith, 1944); in one of the cases of Barnes et al (1949) it appeared to be 16 days.…”

Section: Discussionsupporting

confidence: 89%

Acute Infectious Lymphocytosis

Dunn¹

1952

BMJ

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Section: Discussionsupporting

confidence: 89%

Acute Infectious Lymphocytosis

Dunn¹

1952

BMJ

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“…phenomenon by Rohn and Bond (2) have suggested that the primary visible changes occur in the nuclei of polymorphonuclear leukocytes. They were unable to demonstrate this phenomenon in lymphocytes, although this was subsequently found to occur (3). Others (19,20) have suggested that the basic process may be a fusion and autolysis of the cytoplasmic and nuclear components of the leukocyte.…”

Section: Discussionmentioning

confidence: 95%

Phase Contrast and Interferometric Microscopy of the L.E. Cell Phenomenon

Rifkind

Godman

1957

The Journal of Experimental Medicine

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Alterations in the cellular morphology of polymorphonuclear leukocytes and lymphocytes under the influence of serum from patients having disseminated lupus erythematosus were observed under the phase contrast microscope. These changes appear to involve the cell nucleus without significant visible incorporation of cytoplasm. In the formation of the L.E. body, there is a loss of internal nuclear structure and a subsequent nuclear swelling and extrusion of the nuclear contents from the cell to form the free L.E. body. The possible incorporation of cytoplasmic substance cannot alone account for the large mass of the L.E. body as contrasted with the parent nucleus or nuclear lobe. Measurements of dry mass by means of the interference microscope show a two and one-half-fold increment in dry mass in L.E. bodies compared to parent lymphocyte nuclei. This confirms previous cytochemical studies, and establishes that an influx of protein into the leukocyte nucleus is an integral part of the L.E. phenomenon. That the accumulation of extraneous protein within the L.E. body is simultaneous with or subsequent to a disruption of the normal structure of the leukocyte nucleus is apparent from these studies, but the pathogenesis of this alteration is as yet unknown.

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Nuclear antigens in normal and leukaemic leucocytes: A histochemical study using human auto‐immune antinuclear antibodies

Beck

Paterson

1965

J. Pathol.

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Experimental production of “L.E.” Cells

Cited by 15 publications

References 0 publications

Acute Infectious Lymphocytosis

Acute Infectious Lymphocytosis

Phase Contrast and Interferometric Microscopy of the L.E. Cell Phenomenon

Nuclear antigens in normal and leukaemic leucocytes: A histochemical study using human auto‐immune antinuclear antibodies

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