“…A number of Reynolds-averaged Navier-Stokes (RANS) (Zhang et al, 2002;Heenan et al, 2003;Kleinstreuer & Zhang, 2003;Matida et al, 2004;Jayaraju et al, 2007;Sandeau et al, 2010) and large eddy simulation (LES) studies (Matida et al, 2006;Jayaraju et al, 2008;Debhi, 2011;Cui & Gutheil, 2011) have been reported in the literature. However, accurate prediction of the flow field remains a challenge due to the complexity of the flow in the extrathoracic airways and the limitations of RANS and LES turbulence models.…”