Experimental investigation of effects of platelet-rich plasma on early phases of orthodontic tooth movement

Akbulut, Sibel; Yağcı, Ahmet; Yay, Arzu Hanım; Yalçın, Betül

doi:10.1016/j.ajodo.2018.03.015

Cited by 35 publications

(42 citation statements)

References 31 publications

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“…Güleç et al14 reported that the osteoclast cell counts in the PRP group were less than those in the control group at the first, second, and third weeks despite a higher rate of tooth movement in the PRP group. Akbulut et al28 also demonstrated that the tartrate-resistant acid phosphatase expressions between the groups were not different at all observation times. One reason for this is that a possible immune reaction from usage of an allogenic PRP injection led to different results.…”

Section: Discussionmentioning

confidence: 92%

The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits

2019

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Objective: To determine the effects of a local injection of leukocyte-plateletrich plasma (L-PRP) on orthodontic tooth movement in rabbits. Methods: Twenty-three male New Zealand white rabbits were included in a split-mouth design. Tooth movement with a 100-g nickel-titanium closed-coil spring was performed on the maxillary first premolars. L-PRP was injected submucosally at the buccal and lingual areas of the first premolar in one random side of the maxilla and the other side served as the control and received normal saline. The amount of tooth movement was assessed on three-dimensional digital models on days 0, 3, 7, 14, 21, and 28. Histological findings and osteoclast numbers were examined on day 0 as the baseline and on days 7, 14, and 28. Results: The L-PRP group showed significantly greater cumulative tooth movement at all observed periods. However, a significantly higher rate of tooth movement was observed only on days 0-7 and 7-14. The osteoclast numbers were significantly increased in the L-PRP group on days 7 and 14. Conclusions: Local injection of L-PRP resulted in a transient increase in the rate of tooth movement and higher osteoclast numbers.

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Section: Discussionmentioning

confidence: 92%

The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits

2019

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“…Several animal research investigations and limited clinical studies have shown the effectiveness of platelet-based preparations for accelerating tooth movement. 4,[20][21][22][23][24] The purpose of this study was to investigate the efficiency of i-PRF in accelerating tooth movement. We also evaluated the effect of i-PRF on stimulating the expression of inflammatory cytokines in GCF samples.…”

Section: Introductionmentioning

confidence: 99%

Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement:

Erdur¹,

Karakaslı²,

Öncü³

et al. 2021

The Angle Orthodontist

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Objectives To evaluate the efficiency of injectable platelet-rich fibrin (i-PRF) in accelerating canine tooth movement and to examine levels of the matrix metalloproteinase-8 (MMP-8), interleukin-1β (IL-1β), receptor activator of nuclear factor kappa-light-chain-enhancer of activated B cells ligand (RANKL), and osteoprotegerin (OPG) in the gingival crevicular fluid during orthodontic treatment. Materials and Methods Twenty patients (mean age = 21.4 ± 2.9 years) with Class II Division 1 malocclusion were included in a split-mouth study. The treatment plan for all patients was extraction of maxillary first premolars followed by canine distalization with closed-coil springs using 150 g of force on each side. The study group received i-PRF two times, with a 2-week interval, on one side of the maxilla. The contralateral side served as the control and did not receive i-PRF. Maxillary canine tooth movement was measured at five time points (T1–T5) on each side. Also, the activity of inflammatory cytokines was evaluated at three time points in the gingival crevicular fluid samples. Results There was a significant difference in canine tooth movement between the two groups (P < .001). i-PRF significantly increased the rate of tooth movement, and stimulation in the levels of inflammatory cytokines supported this result (P < .001). The levels of cytokines changed in both groups between T1 and T2. The IL-1β, MMP8, and RANKL values were significantly increased in the study group compared with the control group, while the OPG values were significantly decreased. Conclusions i-PRF-facilitated orthodontics is an effective and safe treatment modality to accelerate tooth movement, and this method can help shorten orthodontic treatment duration.

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“…Both studies showed a positive correlation between local injection of PRP and acceleration of orthodontic tooth movement. On the other hand, Akbulut et al 11 reported no beneficial effects of PRP injections on tooth movement, yet they recommended that further studies be conducted.…”

Section: Introductionmentioning

confidence: 99%

Effect of platelet-rich plasma on the rate of orthodontic tooth movement:

Eltimamy¹,

El-Sharaby²,

Eid³

et al. 2020

The Angle Orthodontist

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Objective To investigate the effect of local injection of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement. Materials and Methods Sixteen female patients were randomly allocated in a split-mouth study design to receive PRP injections with CaCl2 activating solution on one side (intervention side) while the other side received CaCl2 injection only (control side). Canine retraction was performed on 0.017 × 0.025-inch stainless steel archwire applying 1.5 N retraction force. PRP and CaCl2 injections were done at 0, 3, and 6 weeks. The duration of the study was 4 months. Data were collected from digitized models. Assessment of pain accompanying the procedure was done using a visual analogue scale. Results The rate of canine retraction was faster on the intervention side in the first 2 months, with a statistically significant difference in the first month (P = .049). On the other hand, the rate was statistically significantly slower on the intervention side in the third month following cessation of PRP injections (P = .02). Pain increased following injections on both sides. Conclusions PRP showed a positive potential to accelerate the rate of tooth movement when injected in the first 2 months. Repeated injections of PRP to maintain a steady rate of accelerated tooth movement warrant further investigation.

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Experimental investigation of effects of platelet-rich plasma on early phases of orthodontic tooth movement

Cited by 35 publications

References 31 publications

The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits

The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits

Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement:

Effect of platelet-rich plasma on the rate of orthodontic tooth movement:

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