Experimental implantation of hydrogel into the bone

Abstract

The present study deals with the application and possibilities of insoluble hydrophilic gels (poly(2-hydroxyethyl methacrylate] as substitutes of bone tissue experimentally. Their biocompatibility is examined with regard to the porous qualities of the implant and to its chemical structure, and their behavior in the cancellous and compact bone is evaluated. It was found that the modifications of hydrogels used in the experiment are biocompatible, with the compatibility increasing in proportion to increasing porosity. The nonporous and microporous hydrogels are not compatible and are demarcated. The sintered macroporous gel is surrounded by a thin fibrin membrane. By adding methacrylic acid to the hydrogel surface, adhesion increases markedly. Marked destruction also appears in the polymer especially in the cancellous bone. By an active destruction of the polymer, no direct phagocytosis can be proved. Upon breakdown of the implant in the compact bone the activity of the macrophages is delayed. When the gel without methacrylic acid is used alone, destruction does not occur even after 193 days. When methacrylic acid is added to the polymer surface, destruction does occur and the implant is filled only by bone trabeculae.

Controlled release of bioactive TGF-β1 from microspheres embedded within biodegradable hydrogels

“…We are utilizing poly(ethylene glycol) (PEG)-based hydrogels as our scaffold material for the delivery system. Hydrogels, which are typically water-insoluble swollen networks of water-soluble polymer chains, are useful for numerous tissue engineering applications [10][11][12][13][14][15]. As many biocompatible polymers can form hydrogels via chemical or physical cross-linking, PEG remains one of the most widely investigated systems [16][17][18].…”

In vitro haematic proteins adsorption and cytocompatibility study on acrylic copolymer to realise coatings for drug-eluting stents

“…However, results obtained for copolymers were intermediate in respect to values obtained for reference systems. Literature reports that, unlike albumin, fibrinogen adsorption generally not depends on the hydrophilicity degree of the materials [12] while porosity of the surface is an important factor affecting the process [27]. From a morphological analysis of the samples (Fig.…”

Mechanical properties of acrylic bone cement containing PMMA-SiO2 hybrid sol-gel material

“…studies the biocompatibility and possibilities of poly(2-Copolymerization of MMA with MSMA was carried out hydroxyethyl methacrylate) (PHEMA) as a substitute for in benzene solution with BPO as the free radical initiator bone tissue was examined, 29 and the influence of collagen in a 100-mL one-neck flask at 78 ЊC under nitrogen followon the biological tolerance of PHEMA implanted intraosing the literature procedure. 5 The characteristics and propseally was also studied.…”