Experimental evaluation of the anti-ulcer activity of the ethanolic extract of grape (Vitis vinifera) seed in wistar albino rats against aspirin plus pylorus ligation induced gastric ulcer model

Ingale, Anand M.; Pinnelli, Venkata Bharat Kumar; Rajendran, Vijaya

doi:10.18203/2319-2003.ijbcp20161508

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…The gastric lesion was significantly reduced in the grape seed 200 mg/kg group on account of higher antioxidant activity [29] exerted by the high proanthocyanidins content possessing antioxidant actions. …”

Section: Discussionmentioning

confidence: 95%

Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats Against Hydrochloric Acid – Ethanol Induced Ulcer Model

Ingale¹,

Pinnelli

Rajendran

2016

Asian J Pharm Clin Res

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Objectives:To evaluate the antiulcer activity of ethanolic extract of seeds of (grape) Vitis vinifera in Wistar albino rats. Methods:The ethanolic extract of V. vinifera was investigated for its antiulcer activity in Wistar albino rats against hydrochloric acid -ethanolinduced ulcer model. The antiulcer activity was assessed by determining and comparing the gastric volume, pH, free, and total acidity; ulcer number and its inhibition, ulcer severity, and ulcer index.Results: A significant antiulcer activity was observed. The grape seed 100 mg/kg group showed significant (p<0.05) reduction in ulcer number as compared to the control. The grape seed 200 mg/kg showed significant (p<0.05) reduction in ulcer number, free acidity, and gastric lesion as compared to the control. Conclusion:This study indicates that V. vinifera seed extract has potential antiulcer activity in the model tested.

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Section: Discussionmentioning

confidence: 95%

Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats Against Hydrochloric Acid – Ethanol Induced Ulcer Model

Ingale¹,

Pinnelli

Rajendran

2016

Asian J Pharm Clin Res

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“…All the groups were compared with the control group in each model. The difference was considered significant if p<0.05 (Ingale et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation parameter (Ingale et al, 2016) The gastric content was collected to determine its volume, pH, total acidity and free acidity. The mucosal surface of the stomach was scored in terms of ulcer index.…”

Section: Nsaids Induced Ulcermentioning

confidence: 99%

Evaluation of the anti-diarrheal and anti-ulcer activity of hydro-alcoholic extract of aerial part of Tridax procumbens in experimental rats

Chouhan¹,

Saxena²,

Patidar³

2021

Adv Pharm J

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Objective: Aim of the present study was to evaluate the anti-diarrheal & anti-ulcer activity of hydro-alcoholic extract of aerial part of in experimental rats. Adult Wistar rats of 150-200 gm Tridax procumbensMaterial and methods: were used for the study. The antidiarrheal activity of extract was evaluated by castor oil and Tridax procumbens magnesium sulfate induced diarrhea using parameters such as onset of diarrhea, total number of stool and weight of total number of stools. The antiulcer activity of extracts was investigated using ethanol and induced ulcer. The gastric content was collected to determine its volume, pH, total acidity and free acidity. The mucosal surface of the stomach was scored in terms of ulcer index. The effect of the extract in these models was comparable to the standard drugs (Loperamide 3 mg/kg and Ranitidine 50 mg/kg) used.extract was more efficacious in Results: Tridax procumbens reducing number of total stools and weight of stools and significantly increase onset of diarrhea in both the models. % Inhibition of defecation of test extract was also found to 44.92% and 55.88% relatively compare to standard 76.81% and 78.97% in both models. The antiulcer activity of the extracts was confirmed by a reduction in ulcer index along with the decrease in gastric volume, total acidity, and an increase in pH of gastric content in both the models. Conclusion:In conclusion, we can say that extract dose (300 mg/kg) of show significantly Tridax procumbens reducing the condition of diarrhea as well as an ulcer with the help of flavonoids, saponin, alkaloid, tannins, phenols and some other phytoconstituents.

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“…Draksha reduces the number of ulcers, maybe due to a higher polyphenol content or a powerful anti-oxidant, which may contribute to their action. (22). Draksha fruit is rich in sugars, organic acids, and bioflavonoids.…”

Section: Draksha (Vitis Vinifera L)mentioning

confidence: 99%

Efficacy of Jatyadi Kwatha Gandusha in Management of Pittaja Mukhapaka with special reference to Aphthous Ulcer: A Randomized Controlled Clinical Trial

Sutnga,

Angadi,

Sutnga

2024

IJAM

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The condition known as Pittaja Mukhapaka is frequently encountered by patients seeking treatment at the outpatient department of the Ears, Nose, and Throat department. This condition is characterized by inflammation, ulceration, and a burning sensation in the oral mucosa, and is often associated with Aphthous ulcers (Pittaja Mukhapaka). Although modern medicine has several treatment options, including anti-inflammatory drugs, topical corticosteroids, and topical tetracyclines, these treatments have limitations. In contrast, Jatyadi Kwath Churna is a traditional polyherbal composition in ayurvedic medicine that has been used to treat oral problems for centuries. This herbal preparation contains Jati Patra, Guduchi, Draksha, Daru Haridra, Yavasa, Haritaki, Vibhitaki, Madhu, and Amlaki, and is indicated for oral problems in the texts Yogaratnakara and Bhaishajya Ratnavali. Material and Methods: This study aims to evaluate the efficacy of Jatyadi Kwatha Gandusha for Mukha Rogas, a study was conducted with 30 subjects randomly allocated to either Group A (receiving Gandusha of Jatyadi Kwatha and Madhu) or Group B (receiving Triphala Kwatha). Result: Both groups experienced complete relief from discomfort, burning sensations, and excessive salivation, on analysis between the groups with a statistically significant p-value results are equally effective in both groups. Conclusion: The study successfully demonstrated the effectiveness of Jatyadi Kwatha Gandusha and Triphala Kwatha in managing Pittaja Mukhapaka.

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Experimental evaluation of the anti-ulcer activity of the ethanolic extract of grape (Vitis vinifera) seed in wistar albino rats against aspirin plus pylorus ligation induced gastric ulcer model

Cited by 6 publications

References 16 publications

Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats Against Hydrochloric Acid – Ethanol Induced Ulcer Model

Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats Against Hydrochloric Acid – Ethanol Induced Ulcer Model

Evaluation of the anti-diarrheal and anti-ulcer activity of hydro-alcoholic extract of aerial part of Tridax procumbens in experimental rats

Efficacy of Jatyadi Kwatha Gandusha in Management of Pittaja Mukhapaka with special reference to Aphthous Ulcer: A Randomized Controlled Clinical Trial

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