Evaluation of the anti-diarrheal and anti-ulcer activity of hydro-alcoholic extract of aerial part of Tridax procumbens in experimental rats

Abstract

Objective: Aim of the present study was to evaluate the anti-diarrheal & anti-ulcer activity of hydro-alcoholic extract of aerial part of in experimental rats. Adult Wistar rats of 150-200 gm Tridax procumbensMaterial and methods: were used for the study. The antidiarrheal activity of extract was evaluated by castor oil and Tridax procumbens magnesium sulfate induced diarrhea using parameters such as onset of diarrhea, total number of stool and weight of total number of stools. The antiulcer activity of extracts was investigated using ethanol and induced ulcer. The gastric content was collected to determine its volume, pH, total acidity and free acidity. The mucosal surface of the stomach was scored in terms of ulcer index. The effect of the extract in these models was comparable to the standard drugs (Loperamide 3 mg/kg and Ranitidine 50 mg/kg) used.extract was more efficacious in Results: Tridax procumbens reducing number of total stools and weight of stools and significantly increase onset of diarrhea in both the models. % Inhibition of defecation of test extract was also found to 44.92% and 55.88% relatively compare to standard 76.81% and 78.97% in both models. The antiulcer activity of the extracts was confirmed by a reduction in ulcer index along with the decrease in gastric volume, total acidity, and an increase in pH of gastric content in both the models. Conclusion:In conclusion, we can say that extract dose (300 mg/kg) of show significantly Tridax procumbens reducing the condition of diarrhea as well as an ulcer with the help of flavonoids, saponin, alkaloid, tannins, phenols and some other phytoconstituents.