Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats Against Hydrochloric Acid – Ethanol Induced Ulcer Model

Ingale, Anand M.; Pinnelli, Venkata BharatKumar; Rajendran, Vijaya

doi:10.22159/ajpcr.2016.v9i6.14999

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…It shows that higher concentration of the extract possesses better activity on account of their higher proanthocyanidines that are antioxidants as well as gastroprotective agents. 22,27,28 Significant decrease in the number of ulcers was seen in grape seed 100mg/kg group and 200mg/kg group. As there was a reduction in the volume of gastric contents and also a rise in pH of gastric contents, there was a decrease in the number of ulcers in the study groups.…”

Section: Discussionmentioning

confidence: 94%

Experimental evaluation of the anti-ulcer activity of the ethanolic extract of grape (Vitis vinifera) seed in wistar albino rats against aspirin plus pylorus ligation induced gastric ulcer model

Ingale

Pinnelli

Rajendran

2016

Int J Basic Clin Pharmacol

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Background: There is an increased demand for newer safer drugs for the treatment of peptic ulcer disease as its incidence is increasing gradually in view of changing lifestyle and stress. The objective of this study was to evaluate the anti-ulcer activity of ethanol extract of seeds of Vitis vinifera. Methods: The ethanol extract of Vitis vinifera was investigated for its anti-ulcer activity in rats against Aspirin plus Pylorus ligation induced gastric ulcer. The antiulcer activity was assessed by determining and comparing gastric volume, pH, free and total acidity; ulcer number and its inhibition, ulcer severity and ulcer index. Results: A significant antiulcer activity was observed. Pylorus ligation model showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. Conclusions: This present study indicates that Vitis vinifera seed extract have potential anti-ulcer activity in the model tested.

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Section: Discussionmentioning

confidence: 94%

Experimental evaluation of the anti-ulcer activity of the ethanolic extract of grape (Vitis vinifera) seed in wistar albino rats against aspirin plus pylorus ligation induced gastric ulcer model

Ingale

Pinnelli

Rajendran

2016

Int J Basic Clin Pharmacol

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Pharmacokinetic interactions: The effects of selected herbal extracts on permeation of P-glycoprotein substrate drugs across excised pig intestinal tissue

Peterson

Jacobsz

Hamman

et al. 2021

J Herbmed Pharmacol

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Introduction: There is growing concern that co-administered herbal medicines may alter the pharmacokinetics and, therefore, the efficacy and toxicity of Western drugs. The aim of this study was to investigate the potential membrane permeation modulating effects of four herbal extracts, i.e., Harpagophytum procumbens, Hoodia gordonii, Leonotis leonurus, and Vitis vinifera on a model compound, Rhodamine 123 (RH-123). Methods: An in vitro permeation model, i.e., excised pig intestinal tissue, mounted to test chambers in a Sweetana-Grass diffusion apparatus, was used to measure the bi-directional transport of RH-123 in the presence and in the absence of four herbal extracts. The concentration of transported RH-123 in each sample was determined by means of fluorescence spectroscopic analysis. The integrity of the mounted jejunum tissue during experimentation was confirmed by measuring the permeation of Lucifer Yellow through these membranes. Trans-epithelial electrical resistance (TEER) of the mounted membranes was also measured at the onset and termination of each experiment to monitor whether tight junction modulation occurred. Results: H. procumbens extract increased the secretory transport of RH-123, indicative of the induction of P-glycoprotein (P-gp) mediated efflux. H. gordonii extract also increased RH-123’s absorptive transport, coupled with a subsequent decrease in its secretory transport, indicating the P-gp related efflux inhibition. Contrary, L. leonurus extract reduced RH-123’s absorptive transport, accompanied by an increase in its secretory transport. V. vinifera seed extract, however, increased both the absorptive and secretory transport of RH-123. A reduction in TEER was observed in the presence of V. vinifera extract, indicating the modulation of tight junction integrity. Conclusion: The ex vivo pharmacokinetics interactions recorded in the current study suggest that the co-administration of herbal medicines could alter the extent of membrane permeation of Western drugs.

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Experimental Evaluation of the Anti-Ulcer Activity of Grape (Vitis Vinifera) Seed Extract in Wistar Albino Rats Against Hydrochloric Acid – Ethanol Induced Ulcer Model

Cited by 2 publications

References 19 publications

Experimental evaluation of the anti-ulcer activity of the ethanolic extract of grape (Vitis vinifera) seed in wistar albino rats against aspirin plus pylorus ligation induced gastric ulcer model

Experimental evaluation of the anti-ulcer activity of the ethanolic extract of grape (Vitis vinifera) seed in wistar albino rats against aspirin plus pylorus ligation induced gastric ulcer model

Pharmacokinetic interactions: The effects of selected herbal extracts on permeation of P-glycoprotein substrate drugs across excised pig intestinal tissue

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