Experimental cross‐infection of sheep and goats with different isolates of contagious ecthyma virus

Zamri-Saad, M.; Roshidah, I.; Al-Ajeeli, Karim Sadun

doi:10.1111/j.1751-0813.1994.tb03406.x

Cited by 12 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical signs in naïve sheep and goats generally begin as localized erythema and development of pustules and vesicles at the site of infection. These results support findings of other studies, 3,5,8,[19][20][21] which suggest that strains of orf virus antigenically distinct from those in the goat-derived CE vaccine are a cause of disease outbreaks in sheep and goats. Lesions heal by 4 to 8 weeks after infection.…”

Section: Discussionsupporting

confidence: 91%

“…29 Immune responses of sheep to the orf virus involve neutrophils, dendritic cells, T cells (of which CD4+ predominate), B cells, and antibodies. 14,16,20 Relative correlates, which are immune responses with a relationship to protection, 32 are useful measures, but they do not always evaluate actual protection from disease. 14,16,20 Relative correlates, which are immune responses with a relationship to protection, 32 are useful measures, but they do not always evaluate actual protection from disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of homologous and heterologous protection induced by a virulent field strain of orf virus and an orf vaccine in goats

Musser¹,

Waldron²,

Taylor³

2012

ajvr

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Evaluation of homologous and heterologous protection induced by a virulent field strain of orf virus and an orf vaccine in goats

Musser¹,

Waldron²,

Taylor³

2012

ajvr

View full text Add to dashboard Cite

show abstract

“…Cross-infection of orf between sheep and goats can occur, 34 but it is not so uncommon that attempts to transmit the infection from one species to the other are unsuccessful. 26,27 Preliminary results of phylogenetic analyses showed that orf virus strains from sheep and goats cluster differently, suggesting that genetic differences exist between strains from sheep and goats (de la Concha-Bermejillo A, Guo J, Zhang Z, Waldron D: 2001, Characterization of orf virus from goats with severe, persistent, proliferative dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Severe Persistent Orf in Young Goats

et al. 2003

View full text Add to dashboard Cite

Abstract. Orf (contagious ecthyma) is a viral disease of small and wild ruminants, humans, and less frequently other species. In sheep and goats, the disease is characterized by the formation of vesiculo-proliferative lesions in the skin of lips and nostril. Here, a form of generalized orf in 16 goat kids from 2 different locations in west Texas is described. The disease was characterized by multifocal, severe, proliferative dermatitis that persisted from about 2 months of age until the goat kids were euthanized 3 months later. All affected goats were Boer or Boer crosses under 1 year of age. The mean immunoglobulin concentration in sera of affected goats was elevated compared with healthy control goats. Severe to moderate lymphadenomegaly of the nodes draining the areas of the skin affected with orf lesions was present in all 16 goat kids. Suppurative arthritis, chronic fibrinous pneumonia, and premature thymic involution were found in 3, 5, and 7 of the goat kids, respectively. The skin lesions of 3 goat kids were infested with larvae of the opportunistic black garbage fly (Ophira sp.). The orf virus was identified in skin lesions by isolation in Marbin-Darby ovine kidney cells, electron microscopy, and amplification of viral DNA by polymerase chain reaction. The orf virus was not detected in peripheral blood or lymph node mononuclear cells of any of the goats. Cross-neutralization experiments showed that an ovine orf virus antiserum raised in sheep was more effective in neutralizing a sheep orf virus isolate than a caprine orf virus isolate. The clinical and epidemiological characteristics of these orf cases may be the result of susceptibility factors within some individuals of the Boer breed of goats.

show abstract

“…This raises the possibility that differences in the external domain of both A33R and A34R are associated with host-specific requirements during virus infection by EEV. Differences in disease course have been shown following experimental infection with ORFV isolated from sheep or goats (87).…”

Section: Resultsmentioning

confidence: 99%