Experimental coccidiosis provoked by Eimeria acervulina in chicks simultaneously fed on ochratoxin A contaminated diet

Koynarski, V.; Stoev, Stoycho D.; Grozeva, N.; Mirtcheva, Teodora; Daskalov, H.; Mitev, J.; Mantle, Peter G.

doi:10.1016/j.rvsc.2006.07.004

Cited by 47 publications

(40 citation statements)

References 21 publications

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“…Stoev et al (2002b) reported that broiler chicks infected with Eimeria tenella and fed OA had greater intensity of clinical signs, kidney function impairment, and gross and histopathologic changes than chicks infected with E. tenella alone or fed OA alone. Similarly, Koynarski et al (2007) reported that chicks fed OA and infected with E. acervulina had heavier duodenal coccidiosis with higher lesion scores and oocyst indices than chicks infected with E. acervulina alone.…”

Section: Discussionmentioning

confidence: 87%

“…However, Fukata et al (1996), while studying the effect of 3 parts/10 6 OA in S. Typhimurium challenged layer chicks, reported OA as one of the factors that affect the susceptibility of chickens to Salmonella colonization. Koynarski et al (2007) reported that chicks fed OA and infected with Eimeria acervulina had a greater decrease in growth rate, more histological changes and kidney impairment than chicks fed OA alone or infected with Eimeria species alone. Studies conducted in our laboratory revealed that broiler chicks fed OA and inoculated with Escherichia coli had a greater decrease in body weight, alterations in feed conversion efficiency, increased mortality, and more severe gross and histopathological changes than birds fed OA alone or those infected with E. coli alone (Kumar et al, 2003;Kumar et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…OA may increase the severity and/or frequency of secondary infections in birds (Elissalde et al, 1994;Sandhu et al, 1995;Fukata et al, 1996;Koynarski et al, 2007). Elissalde et al (1994) fed 3 parts/10 6 OA to broiler chickens and inoculated them with Salmonella Typhimurium.…”

Section: Introductionmentioning

confidence: 99%

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Individual and combined effects of ochratoxin A andSalmonella entericaserovar Gallinarum infection on pathological changes in broiler chickens

et al. 2008

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Individual and combined effects of ochratoxin A andSalmonella entericaserovar Gallinarum infection on pathological changes in broiler chickens

et al. 2008

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“…The local immune system is also damaged by mycotoxins, resulting in increased susceptibility to infections. Previous studies have shown that OTA induced degenerative and necrotic changes and desquamation of the epithelium in the duodenal and jejunal mucosa, increasing the susceptibility to coccidiosis (Stoev et al, 2002;Koynarski et al, 2007). OTA also increased the susceptibility to, and aggravated the clinicopathological picture of, salmonellosis (Elissalde et al, 1994;Fukata et al, 1995;Gupta et al, 2005;Gupta et al, 2008) and colibacillosis (Kumar et al, 2003;Kumar et al, 2004).…”

Section: Discussionmentioning

confidence: 94%

Effect of ochratoxin A on the intestinal mucosa and mucosa-associated lymphoid tissues in broiler chickens

Solcan

Pavel

Floriștean

et al. 2015

Acta Veterinaria Hungarica

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The immunotoxic effect of ochratoxin A (OTA) on the intestinal mucosaassociated lymphoid tissue and its cytotoxic action on the intestinal epithelium were studied in broiler chickens experimentally treated with the toxin. From the 7th day of life, 80 male broiler chickens (Ross 308) were randomly divided into four groups of 20 birds each. The three experimental groups (E1-3) were treated with OTA for 28 days (E1: 50 µg/kg body weight [bw]/day; E2: 20 µg/kg bw/day; E3: 1 µg/kg bw/day) and the fourth group served as control. Histological examination of the intestinal mucosa and immunohistochemical staining for identification of CD4+, CD8+, TCR1 and TCR2 lymphocytes in the duodenum, jejunum and ileocaecal junction were performed, and CD4+/CD8+ and TCR1/TCR2 ratios were calculated. OTA toxicity resulted in decreased body weight gain, poorer feed conversion ratio, lower leukocyte and lymphocyte count, and altered intestinal mucosa architecture. After 14 days of exposure to OTA, immunohistochemistry showed a significant reduction of the lymphocyte population in the intestinal epithelium and the lamina propria. After 28 days of exposure, an increase in the CD4+ and CD8+ values in both the duodenum and jejunum of chickens in Groups E1 and E2 was observed, but the TCR1 and TCR2 lymphocyte counts showed a significant reduction. No significant changes were observed in Group E3. The results indicate that OTA induced a decrease in leukocyte and lymphocyte counts and was cytotoxic to the intestinal epithelium and the mucosa-associated lymphoid tissue, altering the intestinal barrier and increasing susceptibility to various associated diseases.

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“…Consumption of low levels of mycotoxins through the feeds do not cause overt mycotoxicoses, but often predisposes to various infectious diseases and especially to secondary bacterial infections or to a heavy progression of some often encountered parasitic diseases (Stoev et al, 2000;Koynarski et al, 2007), because of the suppression in both humoral and cellmediated immune response in such animals (Stoev et al, 2000). Suppression of the cellular immune system is a known result after ingestion of several mycotoxins.…”

Section: Effect Of Mycotoxins On Animalsmentioning

confidence: 99%

Mycotoxins in animals: Occurrence, effects, prevention and management

Zaki¹

2012

J. Toxicol. Environ. Health Sci.

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Globalization of the trade in agricultural commodities has contributed significantly to the discussion about potential hazards involved and has increased in particular the awareness of mycotoxins. Safety awareness in food and feed production has also risen due to the simple fact that methods for testing residues and undesirable substances have become noticeably more sophisticated and more available at all points of the supply chain. Mycotoxins comprise of a family of fungal toxins, many of which have been implicated as chemical progenitors of toxicity in man and animals. There are four classes of mycotoxins of major concern namely aflatoxins, zearalenone, ochratoxins, and fumonisins. Formation of mycotoxins varied between species as well as within a given species. A variety of physical, chemical, and biological methods to counteract the mycotoxin problem have been reported, but large-scale, practical, and cost-effective methods for detoxifying mycotoxin-containing feedstuffs are currently not available. Detoxification strategies for the contaminated foods and feeds should be done to reduce or eliminate the adverse actions of mycotoxin to improve food safety and prevent economic losses. The most recent approach to the problem has been the addition to the animal's diet of nonnutritive sorbents that sequester mycotoxins, reduce their gastrointestinal absorption and avoiding their toxic effects on livestock and toxin carryover into animal products. This review comments on the potential hazards of several mycotoxins together with prevention strategy for fungal and mycotoxin contamination.

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Experimental coccidiosis provoked by Eimeria acervulina in chicks simultaneously fed on ochratoxin A contaminated diet

Cited by 47 publications

References 21 publications

Individual and combined effects of ochratoxin A andSalmonella entericaserovar Gallinarum infection on pathological changes in broiler chickens

Individual and combined effects of ochratoxin A andSalmonella entericaserovar Gallinarum infection on pathological changes in broiler chickens

Effect of ochratoxin A on the intestinal mucosa and mucosa-associated lymphoid tissues in broiler chickens

Mycotoxins in animals: Occurrence, effects, prevention and management

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